온도 및 피에이치 민감성 하이드로젤의 인터벤셔널 인젝션에 기반한 간암치료용 약물전달체
    14.
    发明公开
    온도 및 피에이치 민감성 하이드로젤의 인터벤셔널 인젝션에 기반한 간암치료용 약물전달체 有权
    基于传统注射温度和敏感注射液的药物输送系统

    公开(公告)号:KR1020130010402A

    公开(公告)日:2013-01-28

    申请号:KR1020110071184

    申请日:2011-07-18

    Abstract: PURPOSE: A drug delivery system for treating liver cancer based on interventional injection of temperature- and pH-sensitive hydrogel is provided to stably support an anticancer agent and to enable deep injection into microvessel. CONSTITUTION: A drug delivery system for treating liver cancer based on interventional injection of temperature- and pH-sensitive hydrogel contains a drug delivery system with a block copolymer and a therapeutic drug supported inside the drug delivery system. The drug delivery system further contains a contrast agent inside. The block copolymer is a poly(beta-amino ester)-based block copolymer, a polyamidoamine-based polymer, a polyaminoester urethane-based block copolymer, or a sulfonamide-based block copolymer. The poly(beta-amino ester)-based block copolymer is poly(beta-amino ester)-polyethylene glycol-poly(beta-amino ester)(PAE-PEG-PAE), PAE-PCLA-PEG-PCLA-PAE, PAE-PCL-PEG-PCL-PAE or PAEPCGA-PEG-PCGA-PAE. [Reference numerals] (AA) Embodiment 14; (BB) Embodiment 15; (CC) Embodiment 16; (DD) Control group

    Abstract translation: 目的:提供基于介导性注射温敏和pH敏感性水凝胶治疗肝癌的药物递送系统,以稳定地支持抗癌剂并能够深入注射到微血管中。 构成:基于介导性注射温度和pH敏感性水凝胶治疗肝癌的药物递送系统包含药物递送系统,其具有支持药物递送系统内的嵌段共聚物和治疗药物。 药物输送系统还含有造影剂。 嵌段共聚物是基于聚(β-氨基酯)的嵌段共聚物,基于聚酰胺胺的聚合物,聚氨基酯氨基甲酸酯基嵌段共聚物或磺酰胺类嵌段共聚物。 聚(β-氨基酯)基嵌段共聚物是聚(β-氨基酯) - 聚乙二醇 - 聚(β-氨基酯)(PAE-PEG-PAE),PAE-PCLA-PEG-PCLA-PAE,PAE -PCL-PEG-PCL-PAE或PAEPCGA-PEG-PCGA-PAE。 (附图标记)(AA)实施例14; (BB)实施例15; (CC)实施例16; (DD)对照组

    표면이 개질된 췌장소도 봉입용 캡슐 및 이의 제조방법
    15.
    发明公开
    표면이 개질된 췌장소도 봉입용 캡슐 및 이의 제조방법 有权
    具有改性表面的封装胰蛋白酶片及其制备方法

    公开(公告)号:KR1020120032209A

    公开(公告)日:2012-04-05

    申请号:KR1020100093726

    申请日:2010-09-28

    Abstract: PURPOSE: A capsule for encapsulating pancreas islet having modified surface and a preparation method thereof are provided to effectively block the attack of an immune cell. CONSTITUTION: A capsule for encapsulating pancreas islet having modified surface is as follows. Pancreas islet is encapsulated in a capsule comprised of alginate. The capsule surface is reformed by biocompatible polymer. In the biocompatible polymer, a functional radical is attached to the side chain or end thereof. The functional radical is selected from a group consisting of an amine radical, hydroxyl radical, a carboxyl radical, and a sulfone radical.

    Abstract translation: 目的:提供一种用于包封具有改良表面的胰岛的胶囊及其制备方法,以有效阻断免疫细胞的侵袭。 构成:用于封装具有改性表面的胰岛的胶囊如下。 胰岛被包裹在由藻酸盐组成的胶囊中。 胶囊表面由生物相容性聚合物重整。 在生物相容性聚合物中,功能性基团连接到侧链或其末端。 官能团选自胺基,羟基,羧基和砜基。

    화합물, 이를 포함하는 조성물, 이를 이용한 연료전지용 전극, 이를 이용한 연료전지용 전해질막 및 이를 채용한 연료전지
    16.
    发明公开
    화합물, 이를 포함하는 조성물, 이를 이용한 연료전지용 전극, 이를 이용한 연료전지용 전해질막 및 이를 채용한 연료전지 无效
    化合物,包含该化合物的组合物,使用该化合物的燃料电池,使用其的燃料电池的电解质膜和使用至少一个电极和电解质膜的燃料电池

    公开(公告)号:KR1020110126033A

    公开(公告)日:2011-11-22

    申请号:KR1020110020616

    申请日:2011-03-08

    Abstract: PURPOSE: A compound is provided to ensure excellent heat resistance and phosphoric acid resistance and to obtain a fuel cell with an improved lifetime property and cell performance when applied to the electrode and the electrolyte film for the fuel cell. CONSTITUTION: A compound is a polymerization product of a composition that contains a diisocyanate-based compound represented by chemical formula 1 below and an aromatic polyol represented by chemical formula 2, wherein A1 and A2 are each independently a substituted or unsubstituted C1-C30 alkylene group, a substituted or unsubstituted C2-C30 alkenylene group, a substituted or unsubstituted C2-C30 alkynylene group, a substituted or unsubstituted C6-C30 arylene group, a substituted or unsubstituted C2-C30 heteroarylene group, a substituted or unsubstituted C4-C30 carbon cyclic group, or a substituted or unsubstituted C6-C30 condensed polycyclic group; m is 0 or 1; R1 is a hydrogen atom or -P(-O)RR'; R and R' are each independently a hydrogen atom, a C1-C30 alkyl group, or a C6-C30 aryl group; and L is represented by chemical formula 1A.

    Abstract translation: 目的:提供一种化合物以确保优异的耐热性和耐磷酸性,并且当应用于燃料电池的电极和电解质膜时,获得具有改善的寿命特性和电池性能的燃料电池。 构成:化合物是含有下述化学式1表示的二异氰酸酯系化合物和由化学式2表示的芳香族多元醇的组合物的聚合产物,其中A1和A2各自独立地为取代或未取代的C1-C30亚烷基 取代或未取代的C 2 -C 30亚烯基,取代或未取代的C 2 -C 30亚炔基,取代或未取代的C 6 -C 30亚芳基,取代或未取代的C 2 -C 30亚杂芳基,取代或未取代的C 4 -C 30碳环 基团或取代或未取代的C 6 -C 30稠合多环基团; m为0或1; R1是氢原子或-P(-O)RR'; R和R'各自独立地为氢原子,C 1 -C 30烷基或C 6 -C 30芳基; L由化学式1A表示。

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