公开(公告)号：KR101522626B1

公开(公告)日：2015-05-22

申请号：KR1020140121278

申请日：2014-09-12

Applicant: 서울대학교산학협력단

Inventor： 신종헌 ,  오기봉 ,  줄리안티엘린

IPC: C07D498/04 ,  A61K31/424 ,  A61K31/423 ,  A61P31/04

CPC classification number: Y02A50/473 ,  Y02A50/481

Abstract: 본발명은해양유래곰팡이(Penicllium Herquei)를배양및 추출하는방법, 배양액으로부터분리된효소저해활성(Sortase A Inhibition Activity)을갖는신규페날레논유도체화합물및 이를유효성분으로함유한효소저해제조성물에관한것이다. 본발명에따라해양유래곰팡이로부터추출분리된페날레논유도체화합물은병원성그람양성박테리아표면에존재하는효소(Sortase)에대한강한저해활성을보여, 이를포함하는조성물은세균감염성질병의치료를위한조성물로유용하게이용될 수있다.

公开(公告)号：KR1020140114522A

公开(公告)日：2014-09-29

申请号：KR1020130028231

申请日：2013-03-15

Applicant: 서울대학교산학협력단

Inventor： 오동찬 ,  엄수현 ,  신종헌 ,  오기봉 ,  이상국

IPC: C07K7/64 ,  A61K38/12 ,  A61P31/04

CPC classification number: Y02A50/473 ,  Y02A50/481

Abstract: Provided are a novel cyclic peptide compound, an antibiotic and anti-cancer use thereof, and a producing method thereof. The compound as an antimicrobial or anti-cancer drug can be used to treat infection or cancer arising from or caused by microorganisms.

Abstract translation: 提供一种新的环肽化合物，抗生素和抗癌用途及其制备方法。 作为抗微生物剂或抗癌药物的化合物可用于治疗由微生物引起或由微生物引起的感染或癌症。

公开(公告)号：KR1020140112273A

公开(公告)日：2014-09-23

申请号：KR1020130026805

申请日：2013-03-13

Applicant: 서울대학교산학협력단

Inventor： 신종헌 ,  오기봉 ,  줄리안티엘린

IPC: C07D493/04 ,  C07D307/77 ,  A61K31/34 ,  A61P31/04

CPC classification number: Y02A50/473 ,  Y02A50/481 ,  C07D493/04 ,  A61K31/34 ,  C07D307/77 ,  C07D493/00 ,  C07D493/02

Abstract: The present invention relates to a method for culturing and extracting marine-borne fungi Penicllium Herquei, to a novel phenalenone derivative compound isolated from a culture liquid and having an enzyme inhibiting activity (sortase A inhibiting activity), and to an enzyme inhibitor composition containing the same. The phenalenone derivative compound extracted and isolated from marine-borne fungi exhibits a strong inhibitory activity against an enzyme (sortase) present on the surfaces of pathogenic gram-positive bacteria, and thus the composition containing the phenalenone derivative compound can be useful as a composition for treating bacterial infectious diseases.

Abstract translation: 本发明涉及一种培养和提取海洋真菌Penicllium Herquei的方法，其用于从培养液中分离并具有酶抑制活性（分选酶A抑制活性）的新型phenalenone衍生物化合物，以及含有 相同。 从海洋真菌中提取和分离的吩噻乐芬衍生物对病原性革兰氏阳性菌表面存在的酶（分选酶）表现出强烈的抑制活性，因此，含有萘那酮衍生物的组合物可用作 治疗细菌性传染病。