[18F]폴리프라이드의 개선된 제조방법
    12.
    发明公开
    [18F]폴리프라이드의 개선된 제조방법 有权
    [18F] FALLYPRIDE的改进制备方法

    公开(公告)号:KR1020110028765A

    公开(公告)日:2011-03-22

    申请号:KR1020090086354

    申请日:2009-09-14

    CPC classification number: C07D207/09

    Abstract: PURPOSE: An automatic method for preparing [18F]fallypride is provided to the kind of base and addition amount of a solvent. CONSTITUTION: A method for preparing [18F]fallypride comprises: a step of adsorbing fluorine-18 onto a polymer ion exchange cartridge; a step of eluting fluorine-18 by adding a mixture of alcohol/water or alcohol; a step of adding CH_3CN and reacting at 50-120°C for 5-35 minutes to prepare [18F]fallypride crude product; and a step of purifying the [18F]fallypride crude product. The polymer ionexchange cartridge is QMA cartridge or Chromafix PS-HCO3 cartridge.

    Abstract translation: 目的:提供一种用于制备[18F] fallypride的自动方法,用于碱的种类和溶剂的添加量。 构成:一种制备[18 F]菲力布的方法,包括:将氟-18吸附到聚合物离子交换盒上的步骤; 通过加入醇/水或醇的混合物洗脱氟-18的步骤; 加入CH 3 CN并在50-120℃反应5-35分钟制备[18 F] fallypride粗产物的步骤; 和纯化[18 F] fallypride粗产物的步骤。 聚合物离子交换墨盒是QMA墨盒或Chromafix PS-HCO3墨盒。

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