公开(公告)号：KR1020130114543A

公开(公告)日：2013-10-18

申请号：KR1020120037004

申请日：2012-04-09

Applicant: 성균관대학교산학협력단 ,  서울대학교산학협력단

Inventor： 이진규 ,  주국연 ,  이정희

IPC: A61K49/10 ,  A61K49/12 ,  A61K49/16 ,  A61K49/18

CPC classification number: A61K49/1818 ,  A61K49/103 ,  A61K49/106 ,  A61K49/126 ,  A61K49/16 ,  A61K49/186

Abstract: PURPOSE: A nuclear magnetic resonance image contrast agent is provided to be dispersed well in water, free of cytotoxin, and have a long retention time in vivo based on melanin nanoparticles with an identical size and shape. CONSTITUTION: A nuclear magnetic resonance(NMR) image contrast agent comprises: a melanin nanoparticle which is stably dispersed in water; a paramagnetic metal ion which is covalently bonded with the melanin nanoparticle; and a modified PEG on the surface of the melanin nanoparticle. The melanin is extracted from squid ink and has a 30-600nm diameter.

Abstract translation: 目的：提供一种核磁共振图像造影剂，能够很好的分散在水中，无细胞毒素，并且具有相同大小和形状的黑色素纳米颗粒在体内的保留时间长。 构成：核磁共振（NMR）图像造影剂包括：稳定分散在水中的黑色素纳米颗粒; 与黑色素纳米颗粒共价结合的顺磁金属离子; 和在黑色素纳米颗粒表面上的改性PEG。 黑色素从鱿鱼墨提取，直径30-600nm。