인지장애 질환 진단용 다중 마커 및 그 용도
    13.
    发明公开
    인지장애 질환 진단용 다중 마커 및 그 용도 无效
    用于诊断认知障碍及其使用的多重标记

    公开(公告)号:KR1020140042331A

    公开(公告)日:2014-04-07

    申请号:KR1020120108964

    申请日:2012-09-28

    Inventor: 묵인희 한선호

    Abstract: Disclosed in the present invention are a protein differently expressed from a cognitive disorder and a use thereof. A marker according to the present invention, which is selected from the group composed of a transthyretin, an ApoE, an alpha-synuclein, a vitamin D binding protein, a neurogranin, a vimentin, a stathmin, a contactin, and a HDL-cholesterol, especially is used as a mix, to be used as a target content of a cognitive disorder diagnosis or a medicine development.

    Abstract translation: 在本发明中公开的是从认知障碍及其用途不同地表达的蛋白质。 根据本发明的标记,其选自由转甲状腺素蛋白,ApoE,α-突触核蛋白,维生素D结合蛋白,神经粒蛋白,波形蛋白,stathmin,接合蛋白和HDL-胆固醇组成的组 特别用作混合物,用作认知障碍诊断或药物开发的目标含量。

    금 나노입자를 이용한 알츠하이머병 또는 치매 관련 신경계 질환의 진단 방법
    14.
    发明授权
    금 나노입자를 이용한 알츠하이머병 또는 치매 관련 신경계 질환의 진단 방법 有权
    使用金纳米颗粒诊断阿尔茨海默病或与发病相关的神经病变的方法

    公开(公告)号:KR101003124B1

    公开(公告)日:2010-12-21

    申请号:KR1020100005124

    申请日:2010-01-20

    Abstract: PURPOSE: A method for diagnosing Alzheimer disease or dementia-associated nerve system using gold nanopaticles is provided to confirm the presence of beta-amyloid aggregation and to simply diagnose the disease. CONSTITUTION: A method for confirming the presence of beta-amyloid aggregation inhibitor in a test sample comprises: a step of chemically binding gold nanoparticles and beta-amyloid; a step of mixing the gold nanoparticle-beta-amyloid to the test sample; and a step of comparing the precipitation of the gold nanoparticles with that of a control group or comparing by absorbance of supernatant.

    Abstract translation: 目的:提供一种使用金纳米颗粒诊断阿尔茨海默病或痴呆相关神经系统的方法,以证实β-淀粉样蛋白聚集的存在并简单地诊断该疾病。 构成:用于确认测试样品中β-淀粉样蛋白聚集抑制剂的存在的方法包括:化学结合金纳米颗粒和β-淀粉样蛋白的步骤; 将金纳米颗粒-β-淀粉样蛋白混合到测试样品的步骤; 以及比较金纳米颗粒与对照组的沉淀或通过上清液的吸光度进行比较的步骤。

    TSP-1을 포함하는 알츠하이머병 예방 또는 치료용 조성물
    16.
    发明公开
    TSP-1을 포함하는 알츠하이머병 예방 또는 치료용 조성물 审中-实审
    用于预防或治疗阿尔茨海默病的组合物,包含TSP-1

    公开(公告)号:KR1020170085792A

    公开(公告)日:2017-07-25

    申请号:KR1020160005364

    申请日:2016-01-15

    Abstract: 본원은트롬보스폰딘-1(TSP-1) 단백질또는그 유전자를유효성분으로포함하는, 알츠하이머병예방또는치료용약학조성물에관한것으로, 본발명의조성물에의하여알츠하이머병뇌에서아밀로이드베타독성으로인한수상돌기스파인손실이예방되거나회복될수 있다.

    Abstract translation: 本文血小板反应蛋白-1(TSP-1)蛋白或作为涉及,阿尔茨海默氏病预防或治疗,其包括作为活性成分,水,由本发明的组合物的药物组合物由于在阿尔茨海默氏byeongnoe毒性β淀粉样蛋白的基因 可以防止或恢复脊柱丢失。

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