Abstract:
Disclosed in the present invention are a protein differently expressed from a cognitive disorder and a use thereof. A marker according to the present invention, which is selected from the group composed of a transthyretin, an ApoE, an alpha-synuclein, a vitamin D binding protein, a neurogranin, a vimentin, a stathmin, a contactin, and a HDL-cholesterol, especially is used as a mix, to be used as a target content of a cognitive disorder diagnosis or a medicine development.
Abstract:
PURPOSE: A method for diagnosing Alzheimer disease or dementia-associated nerve system using gold nanopaticles is provided to confirm the presence of beta-amyloid aggregation and to simply diagnose the disease. CONSTITUTION: A method for confirming the presence of beta-amyloid aggregation inhibitor in a test sample comprises: a step of chemically binding gold nanoparticles and beta-amyloid; a step of mixing the gold nanoparticle-beta-amyloid to the test sample; and a step of comparing the precipitation of the gold nanoparticles with that of a control group or comparing by absorbance of supernatant.