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公开(公告)号：KR1020130134900A
公开(公告)日：2013-12-10
申请号：KR1020120058771
申请日：2012-05-31
Applicant: 서울대학교산학협력단
IPC: A61K31/343 , A61K31/34 , A61P29/00 , A61P27/14
Abstract: The present invention relates to a composition with isozaluzanin C for preventing or treating allergy or inflammatory diseases. The composition according to one embodiment of the present invention includes isozaluzanin C as an effective element. [Reference numerals] (AA) Emission of 棺-hexosaminidase (%);(BB) Isozaluzanin C;(CC) ketotifen
Abstract translation: 本发明涉及具有用于预防或治疗过敏或炎性疾病的异恶唑烷酮C的组合物。 根据本发明的一个实施方案的组合物包括作为有效成分的异恶唑烷酮C. [AA]（AA）（AA）的排出物（％）;（BB）异恶唑烷酮C（CC）酮替芬
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12.发明公开월계수 잎의 단일성분 추출물을 함유한 파킨슨병과 퇴행성 신경계 뇌질환의 예방 및 치료용 조성물 无效通过使用其他化合物从LAURUS NOBILIS提取物处理和/或预防帕金森病和神经性脑病的组合物提取物
公开(公告)号：KR1020100036052A
公开(公告)日：2010-04-07
申请号：KR1020080095486
申请日：2008-09-29
Applicant: 서울대학교산학협력단
IPC: A61K31/343 , A61K36/54 , A61P25/16 , A61P25/28
Abstract: PURPOSE: A composition for preventing and treating neurodegenerative diseases and Parkinson's disease containing Laurus nobilis leaves is provided to suppress apoptosis and intracellular ROS(reactive oxygen species) and reduce overexpression of active caspase-3 and a-synuclein. CONSTITUTION: A composition for preventing and treating Parkinson's disease and neurodegenerative disease contains single ingredient isolated from hexane layer and chloroform layer of Laurus nobilis leaves. The single ingredient is costunolide, dehydrocostuslactone or spirafolide, or 3 alpha-acetoxyeudesma-1,4(15),11(13)-triene-12,6alpha-olide. The single ingredient isolated from chloroform layer of Laurus nobilis leaves is reynosin.
Abstract translation: 目的：提供一种用于预防和治疗神经变性疾病的组合物和含有金牛座叶的帕金森氏病，以抑制凋亡和细胞内ROS（活性氧），并减少活性半胱天冬酶-3和α-突触核蛋白的过表达。 构成：用于预防和治疗帕金森病和神经变性疾病的组合物含有从己烯层和金牛座叶氯仿层分离的单一成分。 单一成分是肋骨瓜内苷，脱氢放疗曲安奈德或曲安奈德，或3种α-乙酰胆固醇-1,4（15），11（13） - 三烯-12,6α-橄榄。 从金牛座叶子的氯仿层分离的单一成分是reynosin。
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公开(公告)号：KR101418458B1
公开(公告)日：2014-07-16
申请号：KR1020120058771
申请日：2012-05-31
Applicant: 서울대학교산학협력단
IPC: A61K31/343 , A61K31/34 , A61P29/00 , A61P27/14
Abstract: 본 발명은 이소잘루자닌 C를 포함하는, 알레르기 또는 염증성 질환의 예방 또는 치료용 조성물에 관한 것이다.
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公开(公告)号：KR101092620B1
公开(公告)日：2011-12-13
申请号：KR1020100055114
申请日：2010-06-10
Applicant: 서울대학교산학협력단
IPC: A61K31/7048 , A61K31/34 , A61K31/19 , A61P25/00
CPC classification number: A61K31/365 , A61K31/215 , A61K36/54
Abstract: PURPOSE: A composition containing sesquiterpene compound for preventing or treating neurodegenerative diseases is provided to suppress deformation of alpha-synuclein. CONSTITUTION: A composition for preventing or treating neurodegenerative diseases contains sesquiterpene of isozaluzanin C, magnolialide, santamarine, lucentolide, 1beta-hydroxyarbusculin A, and methyl 1beta, 2beta, 6 alpha-trihydroxy-5alpha,7alphaH-eudesma-4(15),11(13)-dien-12-oate as an active ingredient. The neurodegenerative diseases are Parkinson's disease, Alzheimer's disease, or Lewy body dementia. The sesquiterpene compound is isolated from chloroform of Laurus nobilis L.
Abstract translation: 目的：提供含有用于预防或治疗神经变性疾病的倍半萜烯化合物的组合物，以抑制α-突触核蛋白的变形。 构成：用于预防或治疗神经退行性疾病的组合物包含异唑烷酮C，草甘膦，马铃薯碱，lucentolide，1beta-hydroxyarbusculin A和甲基1beta，2beta，6α-三羟基-5α，7αH-eudesma-4（15），11 （13） - 二烯-12-酸酯作为活性成分。 神经变性疾病是帕金森病，阿尔茨海默病或路易体痴呆。 倍半萜烯化合物从金牛座Laurus L.
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公开(公告)号：KR102038054B1
公开(公告)日：2019-10-29
申请号：KR1020170082753
申请日：2017-06-29
Applicant: 서울대학교산학협력단
IPC: C07D209/56 , A61K31/404 , A61K31/403 , C12N1/20 , C12R1/465 , C12P5/00
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Patent Agency Ranking
公开(公告)号：KR101911892B1
公开(公告)日：2018-10-25
申请号：KR1020160170409
申请日：2016-12-14
Applicant: 서울대학교산학협력단
IPC: C07D225/02 , A61K31/395 , C12N1/20 , C12P17/10 , C12P17/18 , A23K20/132 , C12R1/465
CPC classification number: A23K20/132 , A61K31/395 , C07D225/02 , C12N1/20 , C12P17/10 , C12P17/18 , C12R1/465 , Y02A50/473
Abstract: 화학식 1 내지화학식 3 중어느하나로표시되는화합물, 이의이성질체, 유도체, 용매화물, 또는약학적으로허용가능한염, 이의생산방법및 용도를제공한다. 이에따르면, 항균활성및 항생제내성세균에대한항균활성을이용하여세균및 항생제내성세균의생장을억제하고, 세균에의해유발되거나이것이원인이되는감염질환, 예를들어누에의졸도병을예방또는치료하는데사용할수 있다.
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公开(公告)号：KR1020170078584A
公开(公告)日：2017-07-07
申请号：KR1020170082753
申请日：2017-06-29
Applicant: 서울대학교산학협력단
IPC: C07D209/56 , A61K31/404 , A61K31/403 , C12N1/20 , C12R1/465 , C12P5/00
CPC classification number: C07D209/56 , A61K31/403 , A61K31/404 , C12N1/20 , C12P5/005 , C12R1/465
Abstract: 인돌로테르페노이드화합물, 이를생산하는방법, 및이의용도를제공한다. 상기화합물은항-바이러스활성, 특히항-코로나바이러스활성이있으므로, 코로나바이러스감염질환을예방또는치료하거나, 또는코로나바이러스를소독하는데사용할수 있다.
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公开(公告)号：KR1020160047976A
公开(公告)日：2016-05-03
申请号：KR1020150095365
申请日：2015-07-03
Applicant: 서울대학교산학협력단
CPC classification number: C07K5/02 , A61K31/165 , A61K38/00 , A61K38/06 , A61K45/06 , C07K5/00 , C12P21/02 , C12R1/66
Abstract: 신규한펩티드화합물, 이의생산방법, 및이의용도를제공한다. 상기화합물은항암활성을가지므로, 상기화합물은암을예방또는치료하는데사용할수 있다.
Abstract translation: 本发明提供一种新型肽化合物及其制备方法及其用途。 该化合物具有抗癌活性，因此可用于预防或治疗癌症。 此外，本发明提供了包含脂肽和二苯甲酮的肽化合物，其异构体，衍生物或其药学上可接受的盐。
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公开(公告)号：KR101608562B1
公开(公告)日：2016-04-01
申请号：KR1020130118146
申请日：2013-10-02
Applicant: 서울대학교산학협력단
IPC: C07H17/04 , A61K31/7048 , A61P31/04
Abstract: 본발명에서는소르타제 (sortase)에대하여우수한저해활성을가져서유해세균의감염을방지할수 있는신규한구조의화합물및 이를유효성분으로함유하는항균조성물이제공된다. 이들신규한화합물은소르타제에대하여우수한저해활성을통하여항균효과가있는새로운항균조성물로이용될수 있을뿐만아니라, 다양한항균물질유도체의선도물질로도이용될수 있다. 또한본 발명에따른항균조성물은유해세균의감염증치료및 예방에효과적이어서, 항균성약제학적조성물이나, 구강청정제, 치약등과같은항균성구강조성물, 로션, 크림등과같은항균성화장용조성물, 손세정제, 비누, 바스, 주방용세제등의항균성세정조성물등으로사용될수 있다.
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公开(公告)号：KR101522626B1
公开(公告)日：2015-05-22
申请号：KR1020140121278
申请日：2014-09-12
Applicant: 서울대학교산학협력단
IPC: C07D498/04 , A61K31/424 , A61K31/423 , A61P31/04
CPC classification number: Y02A50/473 , Y02A50/481
Abstract: 본발명은해양유래곰팡이(Penicllium Herquei)를배양및 추출하는방법, 배양액으로부터분리된효소저해활성(Sortase A Inhibition Activity)을갖는신규페날레논유도체화합물및 이를유효성분으로함유한효소저해제조성물에관한것이다. 본발명에따라해양유래곰팡이로부터추출분리된페날레논유도체화합물은병원성그람양성박테리아표면에존재하는효소(Sortase)에대한강한저해활성을보여, 이를포함하는조성물은세균감염성질병의치료를위한조성물로유용하게이용될 수있다.
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