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公开(公告)号：KR1020140090287A
公开(公告)日：2014-07-17
申请号：KR1020120145758
申请日：2012-12-13
Applicant: 포항공과대학교 산학협력단 , 주식회사 제넥신
IPC: A61K9/06 , A61K31/728
CPC classification number: A61K31/728 , A61K9/06 , A61K31/203 , A61K31/573
Abstract: The present invention relates to hyaluronic acid-based hydrogel including a cell differentiating agent or a cell activity inducing material and produced using cucurbituril and polyamine, a cell treatment-assisting composition including the hydrogel, a cell treating composition including the hydrogel including a cell differentiating agent or a cell activity inducing material and mesenchymal stem cells, and a cell treatment-assisting composition including the hyaluronic acid-based hydrogel produced using cucurbituril and polyamine. Another purpose of the present invention relates to a cell treatment composition including the hydrogel and mesenchymal stem cells. The hyaluronic acid-based hydrogel provided in the present invention plays a role as a supplementary material for supporting stem cells which expresses a treatment material used as a cell treatment agent so as to promote the secretion of the treatment material and increase cell survival rates, so that the treatment effects of the cell treatment agent can be maximized. Accordingly, the hyaluronic acid-based hydrogel can be widely used to develop a cell treatment agent which exhibits improved effects.
Abstract translation: 本发明涉及包含细胞分化剂或细胞活性诱导材料并使用葫芦巴和多胺制备的透明质酸系水凝胶，包含该水凝胶的细胞治疗辅助组合物，包含水凝胶的细胞处理组合物，其包含细胞分化剂 或细胞活性诱导材料和间充质干细胞，以及包含使用葫芦巴和多胺制备的透明质酸类水凝胶的细胞治疗辅助组合物。 本发明的另一个目的涉及包含水凝胶和间充质干细胞的细胞处理组合物。 本发明中提供的透明质酸水凝胶作为支持干细胞的辅助材料起作用，其表达用作细胞处理剂的处理材料，以促进处理材料的分泌并增加细胞存活率，因此 可以使细胞处理剂的处理效果最大化。 因此，透明质酸系水凝胶可广泛用于开发显示改善效果的细胞处理剂。
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公开(公告)号：KR101818705B1
公开(公告)日：2018-01-16
申请号：KR1020150102572
申请日：2015-07-20
Applicant: 포항공과대학교 산학협력단
IPC: A61K47/36 , A61K31/203 , A61K31/573 , A61K39/08
CPC classification number: Y02A50/469
Abstract: 본발명은약물을담지한생체적합성히알루론산가교물하이드로겔, 이를포함하는조성물, 및이의제조방법에관한것으로하이드로겔에서의약물방출을통해질병을치료할수 있다.
Abstract translation: 本发明可以用药物通过它涉及一种制造所述的方法中的药物释放eseoui水凝胶装载生物相容的透明质酸交联水凝胶，含有它们的组合物，和疾病。
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Patent Agency Ranking
公开(公告)号：KR1020170010651A
公开(公告)日：2017-02-01
申请号：KR1020150102572
申请日：2015-07-20
Applicant: 포항공과대학교 산학협력단
IPC: A61K47/36 , A61K31/203 , A61K31/573 , A61K39/08
CPC classification number: Y02A50/469
Abstract: 본발명은약물을담지한생체적합성히알루론산가교물하이드로겔, 이를포함하는조성물, 및이의제조방법에관한것으로하이드로겔에서의약물방출을통해질병을치료할수 있다.
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公开(公告)号：KR101605528B1
公开(公告)日：2016-03-23
申请号：KR1020120145758
申请日：2012-12-13
Applicant: 포항공과대학교 산학협력단 , 주식회사 제넥신
IPC: A61K9/06 , A61K31/728
Abstract: 본발명은세포분화제또는세포활성유도물질을포함하고, 쿠커비투릴과폴리아민을이용하여제조된히알루론산기반하이드로겔, 상기하이드로겔을포함하는세포치료보조용조성물, 상기세포분화제또는세포활성유도물질을포함하는하이드로겔과중간엽줄기세포를포함하는세포치료용조성물, 쿠커비투릴과폴리아민을이용하여제조된히알루론산기반하이드로겔을포함하는세포치료보조용조성물및 본발명의또 다른목적은상기하이드로겔과중간엽줄기세포를포함하는세포치료용조성물에관한것이다. 본발명에서제공하는히알루론산기반하이드로겔은세포치료제로서사용되는치료물질을발현시키는줄기세포를지지하는보조제로서의역할을수행하여, 상기치료물질의분비를촉진시키고, 세포생존율을증가시켜서세포치료제의치료효과를극대화시킬수 있으므로, 보다향상된효능을나타내는세포치료제의개발에널리활용될수 있을것이다.
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公开(公告)号：KR101000491B1
公开(公告)日：2010-12-14
申请号：KR1020080038777
申请日：2008-04-25
Applicant: 주식회사 메가젠임플란트 , 포항공과대학교 산학협력단
Abstract: 본 발명은 히알루론산 골충진 복합체 및 그 제조방법에 관한 것으로, 본 발명에 따른 히알루론산 골충진 복합체는 히알루론산 유도체를 포함하는 매트릭스와 이에 충진되어 있는 MGSB를 포함하여, 기존의 골 충진 대체재에 비해서 치조골 재생을 효과적으로 유도할 수 있고, 체내 골 재생 기간에 맞춰 분해 속도가 조절되어진 히알루론산 하이드로젤을 포함하는 히알루론산 골충진 복합체를 사용하여 골 재생 유도를 극대화시킬 수 있다.
히알루론산, MGSB, 골 충진-
公开(公告)号：KR1020100130773A
公开(公告)日：2010-12-14
申请号：KR1020090049465
申请日：2009-06-04
Applicant: 포항공과대학교 산학협력단
CPC classification number: C08B37/0072 , C08B15/10 , C12N11/04
Abstract: PURPOSE: An X-ray ablation method of hyaluronan hydrogel is provided to obtain a new protocol for manufacturing HA-system hydrogel by the short light X-ray irradiation. CONSTITUTION: An X-ray ablation method of hyaluronan hydrogel comprises the following steps: preparing hyaluronan hydrogel; and irradiating X-rays to the hyaluronan hydrogel for inducing the decomposition of the hyaluronan hydrogel through the gel-sol transition. The decomposition speed of the hyaluronan hydrogel is determined by the dose of the X-ray irradiation.
Abstract translation: 目的：提供透明质酸水凝胶的X射线消融方法，以获得通过短光X射线照射制造HA系统水凝胶的新方案。 构成：透明质酸水凝胶的X射线消融法包括以下步骤：制备透明质酸水凝胶; 并向透明质酸水凝胶照射X射线，以通过凝胶 - 溶胶转变诱导透明质酸水凝胶的分解。 透明质酸水凝胶的分解速度由X射线照射的剂量决定。
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公开(公告)号：KR1020090112967A
公开(公告)日：2009-10-29
申请号：KR1020080038777
申请日：2008-04-25
Applicant: 주식회사 메가젠임플란트 , 포항공과대학교 산학협력단
CPC classification number: A61L27/58 , A61L27/20 , A61L27/52 , A61L24/08 , A61L27/40 , A61L27/44 , A61L27/46 , C08L5/08
Abstract: PURPOSE: A hyaluronate bone filling complex and a method for fabricating the same are provided, which obtain excellent reproduction capacity. CONSTITUTION: A hyaluronate bone filling complex comprises a matrix including hyaluronic acid derivative of the hydrogel form and a bone reproduction derivative which is filled in the matrix. The bone reproduction derivative is bone reproduction derivative synthesized by megagen. The bone reproduction derivative is chemical deposition reactant of biphasic calcium phosphate which includes tricalcium phosphate and hydroxyapatite or calcium nitrate tetrahydrate and dibasic ammonium phosphate.
Abstract translation: 目的：提供透明质酸骨填充复合物及其制造方法，其具有优异的再生能力。 构成：透明质酸骨填充复合物包括包含水凝胶形式的透明质酸衍生物的基质和填充在基质中的骨再生衍生物。 骨再生衍生物是由megagen合成的骨再生衍生物。 骨再生衍生物是磷酸二钙和羟基磷灰石或四水合硝酸钙四水合磷酸二钙的化学沉积反应物。
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