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公开(公告)号：KR1020170116811A
公开(公告)日：2017-10-20
申请号：KR1020160044883
申请日：2016-04-12
Applicant: 아주대학교산학협력단 , 인천대학교 산학협력단
IPC: C08J3/075 , C08J3/24 , C08L33/02 , A61K47/48 , A61K38/18 , A61K31/337 , A61L31/14 , A61L27/52 , A61L29/14
CPC classification number: C08J3/075 , A61K31/337 , A61K38/1825 , A61K47/6903 , A61L27/52 , A61L29/145 , A61L31/145 , C08J3/24 , C08J2205/022 , C08L33/02 , C08L2203/02
Abstract: 본발명은주입형이중가교하이드로젤에관한것으로서, 주입형이중가교하이드로젤은펜톤가교반응및 효소가교반응을포함하는방법을이용해합성된기존의단일가교하이드로젤대비기계적물성을향상시킬수 있으며, 또한기존에제시된원-팟합성법대비, 간단하고신속한방법으로이중가교하이드로젤을제조할수 있음과동시에제조조건에따라이중가교하이드로젤의물리/화학적특성을쉽게제어할수 있는제조법을제시한다.
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公开(公告)号：KR1020140037757A
公开(公告)日：2014-03-27
申请号：KR1020130107937
申请日：2013-09-09
Applicant: 아주대학교산학협력단
CPC classification number: A61L27/52 , A61L2400/06
Abstract: The present invention relates to a production method of hydrogel which comprises the following steps producing an enzyme-immobilized supporter; contacting a polymer with a phenol or aniline functional group on a side chain and the enzyme-immobilized supporter under the presence of hydrogen peroxide for crosslinking; and obtaining the hydrogel by separating the enzyme-immobilized supporter. According to the present invention, the polymer with the phenol or aniline functional group on the side chain is crosslinked by the enzyme immobilized on the supporter to form the hydrogel, thereby obtaining the hydrogel without enzymes. Therefore, in vivo stability including an immune reaction by enzymes can be overcome, and the biomedical application range of the hydrogel can be expanded. [Reference numerals] (AA) Oxidizing enzyme-immobilized supporter; (BB,GG) In situ formation hydrogel; (CC) Injection needle; (DD) Enzyme-immobilized supporter; (EE) Polymer solution sterilizing filter; (FF) Polymer solution(in H_2O_2)
Abstract translation: 本发明涉及水凝胶的制造方法，其包括以下步骤：制备酶固定化载体; 使聚合物与侧链上的酚或苯胺官能团和酶固定的载体在过氧化氢存在下接触进行交联; 并通过分离酶固定的支持物获得水凝胶。 根据本发明，通过固定在载体上的酶将侧链上具有苯酚或苯胺官能团的聚合物交联以形成水凝胶，从而得到不含酶的水凝胶。 因此，可以克服包括酶的免疫反应在内的体内稳定性，并且可以扩大水凝胶的生物医学应用范围。 （附图标记）（AA）氧化酶固定化载体; （BB，GG）原位形成水凝胶; （CC）注射针; （DD）酶固定支持物; （EE）聚合物溶液灭菌过滤器; （FF）聚合物溶液（在H_2O_2中）
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公开(公告)号：KR1020120049419A
公开(公告)日：2012-05-17
申请号：KR1020100107782
申请日：2010-11-01
Applicant: 아주대학교산학협력단
CPC classification number: C12P21/00 , A61K47/59 , A61K47/60 , A61K47/61 , A61L31/16 , A61L33/0047 , A61L2300/254 , C07K5/101 , C07K5/1019 , C07K17/08 , C07K17/14 , C12N9/0071 , C12P13/02
Abstract: PURPOSE: A surface immobilization method of a bioactive substance is provided to stably fix a bioactive substance including phenol or catechol molecules on the surface of metal or high molecule material. CONSTITUTION: A surface immobilization method of a bioactive substance is as follows. A bioactive substance including phenol or catechol molecules is prepared. The bioactive substance is combined with the surface of a substrate by processing bioactive substance and polyphenol oxidase on the surface of the substrate. The bioactive substance is cell adhesion peptide including tyrosine.
Abstract translation: 目的：提供生物活性物质的表面固定方法，将金属或高分子材料表面上的苯酚或儿茶酚分子的生物活性物质稳定地固定。 构成：生物活性物质的表面固定方法如下。 制备包括苯酚或儿茶酚分子的生物活性物质。 通过在基材表面上加工生物活性物质和多酚氧化酶将生物活性物质与基底的表面结合。 生物活性物质是包括酪氨酸的细胞粘附肽。
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公开(公告)号：KR101755041B1
公开(公告)日：2017-07-07
申请号：KR1020110043298
申请日：2011-05-09
Applicant: 한양대학교 산학협력단 , 아주대학교산학협력단
Abstract: 본발명은패턴화된세포배양기판및 이를이용한패턴을갖는세포시트제조방법에관한것으로, 온도감응성하이드로젤과세포부착펩타이드를포함하며일면에패턴이형성된패턴화된세포배양기판및 이를이용한패턴을갖는세포시트제조방법에관한것이다. 본발명에따르면, 패턴을유지하면서세포손상없이빠르게배양기판으로부터세포시트를쉽게회수할수 있으며, 패턴을갖는세포시트는인체내 조직중 방향성을가진조직의재생을위한인공조직으로매우유용하게사용될수 있다.
Abstract translation: 本发明是一种图案化的细胞培养基材与此使用利用包括该肽的温度敏感水凝胶和细胞粘附图案并具有形成在一个表面上的图案的图案化的细胞培养基材，并且涉及具有图案的细胞片层制备 到细胞片。 根据本发明，并能迅速且容易地保持所述图案从培养物回收基板上的细胞片层，没有细胞损伤，具有图案的单元片对身体组织人工组织对组织的再生，其具有的方向非常有用 有。
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公开(公告)号：KR101103423B1
公开(公告)日：2012-01-06
申请号：KR1020090083639
申请日：2009-09-04
Applicant: 아주대학교산학협력단
CPC classification number: A61L24/0042 , A61L24/0015 , A61L24/0031 , A61L24/046 , A61L27/18 , A61L27/52 , A61L27/54 , A61L27/58 , A61L2300/252 , A61L2300/256 , A61L2300/406 , A61L2300/41 , A61L2300/414 , A61L2300/416 , A61L2300/426 , A61L2300/43 , A61L2300/602 , C08L71/02
Abstract: 본 발명은 생체 주입형 조직 접착성 하이드로젤 및 이의 생의학적 용도에 관한 것으로, 보다 상세하게는 도파 또는 이의 유도체를 포함하는 생체 주입형 조직 접착성 하이드로젤에 관한 것으로, 상기 생체 주입형 조직 접착성 하이드로젤은 종래 조직 접착성 하이드로젤과 달리 체내에서 일어나는 효소 반응에 의한
in situ 가교 형성을 유도하여 하이드로젤을 형성함으로써 보다 생체적합성이 우수한
in situ 형성 조직 접착성 하이드로젤을 제공하며 동시에 합성 고분자와 천연 고분자의 하이브리드화로 인하여 생체적합성 및 기계적 강도가 우수하고 도파 유도체의 결합을 통해 우수한 조직 접착력을 갖는다. 이러한 하이드로젤은 조직접착 및 지혈용 소재, 조직재생 및 충진용 임플란트 소재, 생리활성 물질 또는 약물 전달체용 담체 등을 포함한 다양한 생의학적 용도로 사용될 수 있다.
In situ 형성 하이드로겔, 조직 접착제, 지혈제, 효소 감응성 하이드로젤, 도파민, 티라민, 하이드록시페닐아세트산, 하이드록시프로피온산-
Patent Agency Ranking
公开(公告)号：KR1020110025530A
公开(公告)日：2011-03-10
申请号：KR1020090083639
申请日：2009-09-04
Applicant: 아주대학교산학협력단
CPC classification number: A61L24/0042 , A61L24/0015 , A61L24/0031 , A61L24/046 , A61L27/18 , A61L27/52 , A61L27/54 , A61L27/58 , A61L2300/252 , A61L2300/256 , A61L2300/406 , A61L2300/41 , A61L2300/414 , A61L2300/416 , A61L2300/426 , A61L2300/43 , A61L2300/602 , C08L71/02
Abstract: PURPOSE: An in situ implantation type tissue adhesion hydrogel and a biomedical use thereof are provided to improve bio compatibility and mechanical strength. CONSTITUTION: An in situ implantation type tissue adhesion hydrogel comprises: a star type polymer which is formed by combining one or more compounds selected from phenol, aniline or their derivative and one or more compounds selected from dopa or its derivative; a heterogeneous mixture of a branched polymer in which one or more compounds selected from phenol, aniline, or their derivative use a water soluble polymer as a linker; and two or more homogeneous or heterogeneous polymers selected from branched polymers.
Abstract translation: 目的：提供原位植入型组织粘附水凝胶及其生物医学用途，以提高生物相容性和机械强度。 构成：原位植入型组织粘附水凝胶包括：通过组合一种或多种选自苯酚，苯胺或其衍生物的化合物和选自多巴或其衍生物的一种或多种化合物形成的星型聚合物; 支链聚合物的不均匀混合物，其中一种或多种选自苯酚，苯胺或其衍生物的化合物使用水溶性聚合物作为连接体; 和两种或多种选自支链聚合物的均相或非均相聚合物。
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公开(公告)号：KR101522462B1
公开(公告)日：2015-05-21
申请号：KR1020130107937
申请日：2013-09-09
Applicant: 아주대학교산학협력단
CPC classification number: A61L27/52 , A61L2400/06
Abstract: 본발명은효소가고정화된지지체를제조하는단계; 측쇄에페놀또는아닐린관능기를갖는고분자와상기지지체를과산화수소존재하에서접촉시켜가교시키는단계; 및상기효소가고정화된지지체를분리하여하이드로젤을수득하는단계;를포함하는하이드로젤의제조방법을제공한다. 본발명에따르면, 지지체에고정화된효소에의해측쇄에페놀또는아닐린관능기를갖는고분자가가교되어하이드로젤이형성되며, 이에따라효소를포함하지않는하이드로젤이얻어진다. 따라서효소로인한면역반응과같은체내안전성문제점을극복할수 있어하이드로젤의생의학적적용범위를확장시킬수 있다.
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公开(公告)号：KR1020120125702A
公开(公告)日：2012-11-19
申请号：KR1020110043298
申请日：2011-05-09
Applicant: 한양대학교 산학협력단 , 아주대학교산학협력단
CPC classification number: A61L27/52 , A61L27/22 , A61L27/38 , A61L2430/30 , C12M3/00
Abstract: PURPOSE: A patterned cell cultivation plate and a producing method of a cell sheet using thereof are provided to rapidly obtain the cell sheet without damaging by culturing cells by using thermo-sensitive hydrogel and cell adhesion peptide as a culture plate. CONSTITUTION: A patterned cell cultivation plate includes thermo-sensitive hydrogel and cell adhesion peptide. The patterned cell cultivation plate has patterns on one surface. The thermo-sensitive hydrogel is obtained by adding carrot peroxidase and hydrogen peroxide to a polymer mixture containing more than one kind of polymer, and dehydrogenation bonding phenol analogs.
Abstract translation: 目的：提供图案化细胞培养板及其使用的细胞片的制造方法，通过使用热敏性水凝胶和细胞粘附肽作为培养板，快速获得细胞片而不损伤培养细胞。 构成：图案化细胞培养板包括热敏水凝胶和细胞粘附肽。 图案化细胞培养板在一个表面上具有图案。 通过在含有多于一种聚合物的聚合物混合物中加入胡萝卜过氧化物酶和过氧化氢以及脱氢键合苯酚类似物来获得热敏水凝胶。
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公开(公告)号：KR1020110002741A
公开(公告)日：2011-01-10
申请号：KR1020090060370
申请日：2009-07-02
Applicant: 아주대학교산학협력단
CPC classification number: A61L27/52 , A61K9/0024 , A61K47/42 , A61L27/54 , A61L2300/252 , A61L2300/256 , A61L2300/406 , A61L2300/41 , A61L2300/414 , A61L2300/416 , A61L2300/43 , A61L2300/602 , A61L2400/06
Abstract: PURPOSE: An internal implantation type hydrogel and biomedical use thereof is provided, which can be applied to implant material for tissue regeneration and filling. CONSTITUTION: An internal implantation type hydrogel comprises more than two polymers expressed as a chemical formula 1 of the same kind or different kind and combined with phenol derivative or aniline derivative. The internal implantation type hydrogel is connected by the dehydrogenation bonding between the aniline derivative or phenol derivative. In the chemical formula 1 or chemical formula 2, R is hydroxy or amine radical and L is water soluble polymer.
Abstract translation: 目的：提供内部植入型水凝胶及其生物医学应用，可用于组织再生和灌注的植入材料。 构成：内部注入型水凝胶包含多于两种聚合物，其表示为相同种类或不同种类的化学式1，并与苯酚衍生物或苯胺衍生物结合。 内部注入型水凝胶通过苯胺衍生物或苯酚衍生物之间的脱氢键连接。 在化学式1或化学式2中，R是羟基或胺基，L是水溶性聚合物。
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