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公开(公告)号：KR101783308B1
公开(公告)日：2017-09-29
申请号：KR1020160040153
申请日：2016-04-01
Applicant: 아주대학교산학협력단 , 인천대학교 산학협력단
CPC classification number: A61K47/40 , A61K9/0019 , A61K9/06 , A61L26/0066 , A61L26/008 , A61L2400/06 , A61L2430/34 , A61L27/52 , A61K6/02 , A61L27/26 , A61L27/54 , A61L2300/40 , A61L2300/418 , A61L2300/60 , A61L2300/802 , A61L2430/00
Abstract: 본발명은γ-사이클로덱스트린을함유한생체주입형조직접착성하이드로젤및 이의제조방법에관한것으로서, 상기γ-사이클로덱스트린을함유한생체주입형조직접착성하이드로젤을피부접착제로이용할경우, γ-사이클로덱스트린을함유한생체주입형조직접착성하이드로젤은α- 및β-사이클로덱스트린보다더 큰소수성공동을가짐으로써호스트-게스트상호작용보다더 강력한상호작용이일어나며, 또한수소결합을통해젤라틴접착제의응집력및 접착성모두를향상시킬수 있으며, 또한, 우수한세포생존율을갖는γ-사이클로덱스트린을함유한생체주입형조직접착성하이드로젤을이용하여피부절개를접착함으로써조직의재생을효과적으로촉진할수 있다.
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公开(公告)号：KR1020100048370A
公开(公告)日：2010-05-11
申请号：KR1020080107491
申请日：2008-10-31
Applicant: 아주대학교산학협력단
Abstract: PURPOSE: A heparin-pluronic combination is provided to ensure heparin activation and to effectively control hydrophobic drug and protein release. CONSTITUTION: A method for manufacturing pluronic-conjugated heparin derivatives comprises: a step of modifying hydroxyl, both terminal groups, or one terminal group with carboxyl group using succinic anhydride, dimethyl ammonium pyridine, and triethylamine to obtain carboxylated pluronic; and a step of conjugating heparin to the carboxylated pluronic.
Abstract translation: 目的：提供肝素pluronic组合以确保肝素激活和有效控制疏水性药物和蛋白质释放。 构成：用于制造普鲁隆络合的肝素衍生物的方法包括：使用琥珀酸酐，二甲基铵吡啶和三乙胺使羟基，两个末端基团或一个具有羧基的末端基团进行改性以获得羧化的pluronic; 以及将肝素与羧化的pluronic缀合的步骤。
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公开(公告)号：KR1020090126373A
公开(公告)日：2009-12-09
申请号：KR1020080052418
申请日：2008-06-04
Applicant: 아주대학교산학협력단
IPC: C08G63/91 , C08G65/48 , C08G65/332 , A61K9/00
Abstract: PURPOSE: A 6-arm poly(L-lactide)-polyethylene block copolymer is provided to be effective for micelle formation and to control a drug release profile by controlling a chain length of poly(L-lactide) within micelle. CONSTITUTION: A micelle for drug release comprises a 6-arm poly(L-lactide)-polyethylene glycol block copolymer represented by the following chemical formula I. A method for preparing the 6-arm poly(L-lactide)-polyethylene glycol block copolymer comprises the steps of: (i) performing ring opening polymerization of L-lactide using dipentaerythritol as a starting material in the presence of a catalyst of tin octate; and (ii) conjugating carboxymethyl mono-methoxy poly(ethylene glycol) to the 6-arm poly(L-lactide).
Abstract translation: 目的：提供6臂聚（L-丙交酯） - 聚乙烯嵌段共聚物，用于通过控制胶束内的聚（L-丙交酯）的链长来有效地进行胶束形成和控制药物释放曲线。 构成：用于药物释放的胶束包含由以下化学式I表示的6-臂聚（L-丙交酯） - 聚乙二醇嵌段共聚物。制备6-臂聚（L-丙交酯） - 聚乙二醇嵌段共聚物的方法 包括以下步骤：（i）在辛酸锡催化剂存在下，使用二季戊四醇作为起始原料进行L-丙交酯的开环聚合; 和（ii）将羧甲基单甲氧基聚（乙二醇）与6-臂聚（L-丙交酯）缀合。
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公开(公告)号：KR101522462B1
公开(公告)日：2015-05-21
申请号：KR1020130107937
申请日：2013-09-09
Applicant: 아주대학교산학협력단
CPC classification number: A61L27/52 , A61L2400/06
Abstract: 본발명은효소가고정화된지지체를제조하는단계; 측쇄에페놀또는아닐린관능기를갖는고분자와상기지지체를과산화수소존재하에서접촉시켜가교시키는단계; 및상기효소가고정화된지지체를분리하여하이드로젤을수득하는단계;를포함하는하이드로젤의제조방법을제공한다. 본발명에따르면, 지지체에고정화된효소에의해측쇄에페놀또는아닐린관능기를갖는고분자가가교되어하이드로젤이형성되며, 이에따라효소를포함하지않는하이드로젤이얻어진다. 따라서효소로인한면역반응과같은체내안전성문제점을극복할수 있어하이드로젤의생의학적적용범위를확장시킬수 있다.
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Patent Agency Ranking
公开(公告)号：KR1020120125702A
公开(公告)日：2012-11-19
申请号：KR1020110043298
申请日：2011-05-09
Applicant: 한양대학교 산학협력단 , 아주대학교산학협력단
CPC classification number: A61L27/52 , A61L27/22 , A61L27/38 , A61L2430/30 , C12M3/00
Abstract: PURPOSE: A patterned cell cultivation plate and a producing method of a cell sheet using thereof are provided to rapidly obtain the cell sheet without damaging by culturing cells by using thermo-sensitive hydrogel and cell adhesion peptide as a culture plate. CONSTITUTION: A patterned cell cultivation plate includes thermo-sensitive hydrogel and cell adhesion peptide. The patterned cell cultivation plate has patterns on one surface. The thermo-sensitive hydrogel is obtained by adding carrot peroxidase and hydrogen peroxide to a polymer mixture containing more than one kind of polymer, and dehydrogenation bonding phenol analogs.
Abstract translation: 目的：提供图案化细胞培养板及其使用的细胞片的制造方法，通过使用热敏性水凝胶和细胞粘附肽作为培养板，快速获得细胞片而不损伤培养细胞。 构成：图案化细胞培养板包括热敏水凝胶和细胞粘附肽。 图案化细胞培养板在一个表面上具有图案。 通过在含有多于一种聚合物的聚合物混合物中加入胡萝卜过氧化物酶和过氧化氢以及脱氢键合苯酚类似物来获得热敏水凝胶。
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公开(公告)号：KR1020110002741A
公开(公告)日：2011-01-10
申请号：KR1020090060370
申请日：2009-07-02
Applicant: 아주대학교산학협력단
CPC classification number: A61L27/52 , A61K9/0024 , A61K47/42 , A61L27/54 , A61L2300/252 , A61L2300/256 , A61L2300/406 , A61L2300/41 , A61L2300/414 , A61L2300/416 , A61L2300/43 , A61L2300/602 , A61L2400/06
Abstract: PURPOSE: An internal implantation type hydrogel and biomedical use thereof is provided, which can be applied to implant material for tissue regeneration and filling. CONSTITUTION: An internal implantation type hydrogel comprises more than two polymers expressed as a chemical formula 1 of the same kind or different kind and combined with phenol derivative or aniline derivative. The internal implantation type hydrogel is connected by the dehydrogenation bonding between the aniline derivative or phenol derivative. In the chemical formula 1 or chemical formula 2, R is hydroxy or amine radical and L is water soluble polymer.
Abstract translation: 目的：提供内部植入型水凝胶及其生物医学应用，可用于组织再生和灌注的植入材料。 构成：内部注入型水凝胶包含多于两种聚合物，其表示为相同种类或不同种类的化学式1，并与苯酚衍生物或苯胺衍生物结合。 内部注入型水凝胶通过苯胺衍生物或苯酚衍生物之间的脱氢键连接。 在化学式1或化学式2中，R是羟基或胺基，L是水溶性聚合物。
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公开(公告)号：KR101001270B1
公开(公告)日：2010-12-14
申请号：KR1020080107491
申请日：2008-10-31
Applicant: 아주대학교산학협력단
Abstract: 본 발명은 플루로닉이 결합된 헤파린 유도체의 제조와 그에 대한 생의학적 활용에 대한 것으로, 더욱 상세하게는 플루로닉 고분자 말달을 카르복실화시켜 카르복실화 플루로닉을 제조한 후, 상기 제조된 카르복실화 플루로닉의 카르복실산 잔기에 헤파린을 화학적으로 결합시켜 제조된 헤파린-플루로닉과 이를 이용한 약물 수송체 및 기타 생체소재로의 활용에 관한 것이다.
헤파린, 플루로닉, 하이드로겔, 나노입자, 약물전달체, 혈액적합성-
公开(公告)号：KR1020100076173A
公开(公告)日：2010-07-06
申请号：KR1020080134113
申请日：2008-12-26
Applicant: 아주대학교산학협력단
Abstract: PURPOSE: Enzyme-triggered injectable hydrogel and a medical purpose thereof are provided to use the hydrogel for a tissue engineering implantation type skeleton, a sustained-release drug delivery, and an organization filler. CONSTITUTION: Enzyme-triggered injectable hydrogel marked with chemical formula (I) is produced by a dehydrogenation combination between phenol analogs of more than one polymer compound, horseradish peroxidase, and hydrogen peroxide. The polymer compound is selected from the group consisting the following: a branched polymer marked with chemical formula (II)a, combined with the phenol analogs; a star type polymer marked with chemical formula (II)b, combined with the phenol analogs; and a linear polymer marked with chemical formula (II)c, combined with the phenol analogs.
Abstract translation: 目的：提供酶触发的可注射水凝胶及其医疗目的，以将组合工程植入型骨架，持续释放药物递送和组织填充剂用于水凝胶。 构成：通过化学式（I）标记的酶触发的可注射水凝胶通过多于一种的聚合物化合物的苯酚类似物，辣根过氧化物酶和过氧化氢之间的脱氢组合产生。 高分子化合物选自由以下组成的组：用化学式（II）a标记的支链聚合物，与酚类似物组合; 用化学式（II）b标记的星型聚合物，与酚类似物组合; 和用化学式（II）c标记的线性聚合物，与酚类似物组合。
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公开(公告)号：KR102251193B1
公开(公告)日：2021-05-12
申请号：KR1020190087660
申请日：2019-07-19
Applicant: 아주대학교산학협력단 , 인천대학교 산학협력단
Abstract: 과산화칼슘을이용한카테콜아민코팅방법및 이를이용한저-결합세포배양플레이트제조방법에관한것으로, 구체적으로는과산화칼슘(CaO2)이첨가된카테콜아민용액에코팅하고자하는기재를침지시키는단계를포함하는카테콜아민코팅방법및 상기방법에의하여카테콜아민이코팅된기재를아민-반응성 PEG(mPEG) 용액에침지시키는단계를포함하는저-결합세포배양플레이트제조방법에관한것이다. 본발명에서는산소공급시약으로서과산화칼슘을이용한생체적합물질의표면개질기술을개발하였다. 상기과산화칼슘을통한산소공급은 DA(dopamine hydrochloride) 산화를촉진하여신속하게아민이풍부한기질을생성하였으며, 간단한침지공정으로저-결합배양플레이트를제조할수 있었으며, 상기저-결합배양플레이트에서배양된세포는다른배양플레이트에비하여보다크고컴팩트한세포스페로이드를형성하였다.
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