公开(公告)号：KR1020120129777A

公开(公告)日：2012-11-28

申请号：KR1020120051220

申请日：2012-05-15

Applicant: 전북대학교산학협력단

Inventor： 이존화 ,  난드래라훌 ,  마쓰다기꾸

IPC: A61K39/112 ,  A61K39/02 ,  A61P31/04 ,  A61P31/00

CPC classification number: A61K39/0275 ,  A61K2039/522 ,  Y10S424/826

Abstract: PURPOSE: A living bacteria vaccine composition for salmonellosis prevention including attenuating,mutant strain of immunopotentiation salmonella enteritidis is provided to enhance defense mechanism. CONSTITUTION: A living bacteria vaccine composition for salmonellosis prevention includes attenuating mutant strain of salmonella enteritidis, an immunopotentiation mutant strain which expresses LTB (heat-labile toxin subunit B) of Escherichia coli or a combination thereof. The combination of the immunopotentiation mutant strain and attenuating mutant strain is mixed at the ratio of bacteria numbers of 1:2-1:10. The salmonellosis is domestic fowls salmonellosis or human body salmonellosis. The domestic fowls salmonellosis is avian paratyphoid infection. The avian is hen, duck, turkey, quail, waterfowl, pigeon, and canary. The human body salmonellosis is sitotoxism. [Reference numerals] (AA) Salmonella Enteritidis Δ lon Δ cpxR mutant; (BB) Conservation, culturing; (CC) Vaccinating layer in various conditions; (DD) Verifying defensive power; (EE) Layer vaccination program for defending salmonella infection; (FF) Manufacturing; (GG) Side effect testing; (HH) Excellent safety confirming; (II) Defensive immunity testing; (JJ) Excellent immune confirming; (KK) Outdoor strain inoculating; (LL) Defensive power checking; (MM) Excellent defensive power checking; (NN) After vaccinating; (OO) Clinical symptoms; (PP) Egg contamination; (QQ) Environmental contamination; (RR) Cell-mediated immunity(lymphocyte proliferation reaction, FACS); (SS) Mucous membrane immunity(secretory type IgA); (TT) Humoral immunity (plasma IgG); (UU) After the outdoor strain is infected by dogen; (VV) Inner organ lesion; (WW) Infection checking(virus isolation); (XX) Spawning rate checking; (YY) Egg contamination checking(virus isolation)

Abstract translation: 目的：提供一种预防沙门氏菌病的活细菌疫苗组合物，包括减轻突变型肠炎沙门氏菌的突变株，以增强防御机制。 构成：用于预防沙门氏菌病的活细菌疫苗组合物包括减毒肠炎沙门氏菌的突变菌株，表达大肠杆菌的LTB（热不稳定毒素亚基B）或其组合的免疫增强突变菌株。 免疫增强突变菌株与减毒突变菌株的组合以1：2-1：10的细菌比例混合。 沙门氏菌病是家禽沙门氏菌病或人体沙门氏菌病。 家禽沙门氏菌病是禽类副伤寒感染。 禽鸟是母鸡，鸭子，火鸡，鹌鹑，水禽，鸽子和金丝雀。 人体沙门氏菌是sitotoxism。 （参考号）（AA）肠炎沙门氏菌ΔlonΔcpxR突变体; （BB）保育，培养; （CC）各种条件下的接种层; （DD）验证防御力; （EE）防疫沙门氏菌感染层疫苗接种计划; （FF）制造; （GG）副作用测试; （HH）安全性好; （二）防御性免疫力检测; （JJ）优良免疫确认; （KK）室外菌株接种; （LL）防御力检查; （MM）优秀防守力量检测; （NN）接种疫苗后 （OO）临床症状; （PP）蛋污染; （QQ）环境污染; （RR）细胞介导的免疫（淋巴细胞增殖反应，FACS）; （SS）粘膜免疫（分泌型IgA）; （TT）体液免疫（血浆IgG）; （UU）室外菌株被dogen感染后; （VV）内脏器官损伤; （WW）感染检查（病毒隔离）; （XX）产卵率检查; （YY）鸡蛋污染检查（病毒隔离）

公开(公告)号：KR1020110016369A

公开(公告)日：2011-02-17

申请号：KR1020090105152

申请日：2009-11-02

Applicant: 주식회사 중앙백신연구소 ,  전북대학교산학협력단

Inventor： 이존화 ,  마쓰다기꾸 ,  차우다리에이.,아툴 ,  김삼웅 ,  윤인중 ,  유성식

IPC: A61K39/112 ,  A61P31/04 ,  A23K1/00 ,  C12N1/21

CPC classification number: A61K39/0275 ,  A61K2039/522

Abstract: PURPOSE: A vaccine composition containing Salmonella mutant strain in which Ion and cpxR genes are deleted for preventing fowl typhoid is provided to easily produce and store a live vaccine. CONSTITUTION: A vaccine composition for preventing fowl typhoid contains Salmonella mutant strain in which Ion and cpxR genes are deleted. The Salmonella is Salmonella typhimurium, S. typhi, S. paratyphi, S. sendai, Salmonella Gallinarum, or S. enteritidis. The vaccine composition is administered through oral, transdermal, subcutenous, or nasal cavity administration. The vaccine composition prevents fowl typhoid by administering to birds such as chicken, duck, turkey, waterfowl, and pigeon. A feed additive contains the vaccine composition.

Abstract translation: 目的：提供含有沙门氏菌突变菌株的疫苗组合物，其中Ion和cpxR基因被缺失以防止家禽伤寒，以容易地生产和储存活疫苗。 构成：用于防止禽类伤寒的疫苗组合物含有其中缺失了Ion和cpxR基因的沙门氏菌突变菌株。 沙门氏菌是鼠伤寒沙门氏菌，伤寒沙门氏菌，副伤寒沙门氏菌，沙门氏菌，沙门氏菌或肠炎沙门氏菌。 疫苗组合物通过口服，透皮，皮下或鼻腔给药施用。 疫苗组合物通过对鸡，鸭，火鸡，水禽和鸽子等鸟类进行施用来防止禽类伤寒。 饲料添加剂含有疫苗组合物。