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公开(公告)号：KR101865782B1
公开(公告)日：2018-07-04
申请号：KR1020160157873
申请日：2016-11-25
Applicant: 조선대학교산학협력단
Abstract: 본발명은김치로부터단리한신규한바실러스아밀로리퀴파시엔스 K14 균주, 이균주로부터단리된항균펩타이드및 상기균주로부터신규항균펩타이드를정제하는방법, 및상기신규항균펩타이드의용도에관한것이다. 본발명의바실러스아밀로리퀴페시언스로부터분리정제된항균펩타이드(CSpK14)는 MDR 병원균에대한적적한항균효능뿐만아니라, CSpK14는β-락탐과조합하였을때 그의활성을현저히증대시키므로다약제내성균을제어하기위한조합치료법에유용하게사용될수 있다.
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公开(公告)号：KR1020160034133A
公开(公告)日：2016-03-29
申请号：KR1020140125304
申请日：2014-09-19
Applicant: 재단법인 전남생물산업진흥원 , 조선대학교산학협력단
IPC: A61K31/7034 , A61K36/185 , A61P1/16 , A61P1/00
CPC classification number: A61K31/7034 , A23L29/035 , A61K9/00 , A61K36/185 , Y10S514/893
Abstract: 본발명은히어리로부터분리된화합물을유효성분으로포함하는간 질환치료또는예방용조성물에관한것이다. 또한, 본발명은히어리로부터분리된화합물을유효성분으로포함하는또는간 보호및 간기능개선용식품조성물에관한것이다. 본발명의히어리로부터분리된화합물은식용으로사용되는식물유래추출물로서부작용의문제가없고, 간세포에대한독성도없으며, 간세포보호효과가우수하므로, 본발명의간 보호용조성물은간 질환치료또는예방용의약조성물또는간 기능개선또는간 보호용식품조성물뿐만아니라, 피로회복또는숙취해소와관련된다양한용도로응용될수 있다.
Abstract translation: 本发明涉及一种用于治疗或预防肝病的组合物，其含有从Corylopsis coreana Uyeki分离的化合物作为活性成分。 此外，本发明还涉及一种用于保护肝脏并改善肝功能的食物组合物，其含有从Corylopsis coreana Uyeki分离的化合物作为活性成分。 从Corylopsis coreana Uyeki分离的化合物不会产生不利影响，因为该化合物是来自食用植物的提取物，并且对肝细胞没有细胞毒性，同时表现出优异的肝细胞保护作用。 因此，本发明的肝保护组合物可以应用于肝病的预防或治疗用的药物组合物或用于改善肝功能或保护肝脏的食品组合物以及与疲劳恢复或宿醉治疗相关的其它用途。
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13.发明公开
公开(公告)号：KR1020130073230A
公开(公告)日：2013-07-03
申请号：KR1020110140964
申请日：2011-12-23
Applicant: 조선대학교산학협력단
Abstract: PURPOSE: A cold-adapted lipase derived from mesophilic Streptomyces sp. which catalyzes biodiesel production is provided to selectively hydrolyze p-nitrophenyl dodecanoate (C_10), to non-specifically hydrolyze triolein, to release 1,2- and 1,3-diolein, and to efficiently produce biofuel. CONSTITUTION: Cold-adapted lipase LP28 which catalyzes biodiesel production is isolated from Streptomyces sp. The molecular weight of lipase LP28 measured by SDS-PAGE is 32,400 Da. The optimal temperature and pH are 30 deg. C and pH 8.0. Lipase LP28 selectively hydrolyzes p-nitrophenyl dodecanoate (C_10), non-specifically hydrolyzes triolein, releases 1,2- and 1,3-diolein, and quickly produce biodiesel using palm oil and methanol.
Abstract translation: 目的：从嗜温链霉菌属（Streptomyces sp。）衍生的冷适应脂肪酶。 提供催化生物柴油生产以选择性水解对硝基苯基十二酸酯（C_10），以非特异性水解三油酸酯以释放1,2-和1,3-二油烯，并有效生产生物燃料。 构成：催化生物柴油生产的冷适应脂肪酶LP28从链霉菌属（Streptomyces sp。 通过SDS-PAGE测定的脂肪酶LP28的分子量为32,400Da。 最佳温度和pH值为30度。 C和pH 8.0。 脂肪酶LP28选择性水解对硝基苯基十二酸酯（C_10），非特异性水解三油酸酯，释放1,2-和1,3-二油烯，并使用棕榈油和甲醇快速生产生物柴油。
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公开(公告)号：KR1020120111091A
公开(公告)日：2012-10-10
申请号：KR1020110029387
申请日：2011-03-31
Applicant: 조선대학교산학협력단
CPC classification number: Y02A50/473 , Y02A50/481 , A61K35/74 , A61K9/0019 , A61K9/0053
Abstract: PURPOSE: A novel Bacillus amyloliquefaciens CS61 culture is provided to ensure excellent antibacterial function, DPPH radical removal ability, and high reducing ability. CONSTITUTION: An antioxidant contains Bacillus amyloliquefaciens CS61(KCTC 11901BP) culture as an active ingredient. An anti-inflammatory agent contains the cutlure as an active ingredient. A pharmaceutical composition for suppressing the growth of antibiotic resistant pathogenic microorganism or enteric harmful microorganism contains the culture as an active ingredient. The antibiotic resistant pathogenic microorganism is Methicillin Resistant Staphylococcus aureus(MRSA) or vancomycin resistant enterococcus(VRE). The enteric harmful microorganism is E.coli, Staphylococcus aurues, Enterococcus, or Salmonella.
Abstract translation: 目的：提供一种新型解淀粉芽孢杆菌CS61培养物，以确保优异的抗菌功能，DPPH自由基去除能力和高还原能力。 构成：抗氧化剂含有解淀粉芽孢杆菌CS61（KCTC 11901BP）培养物作为活性成分。 抗炎剂含有作为活性成分的切口。 用于抑制抗生素抗性致病微生物或肠道有害微生物生长的药物组合物含有培养物作为活性成分。 耐药性致病微生物是耐甲氧西林金黄色葡萄球菌（MRSA）或万古霉素耐药性肠球菌（VRE）。 肠道有害微生物是大肠杆菌，金黄色葡萄球菌，肠球菌属或沙门氏菌。
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公开(公告)号：KR102129074B1
公开(公告)日：2020-07-01
申请号：KR1020180107390
申请日：2018-09-07
Applicant: 조선대학교산학협력단
IPC: A61K36/63 , A61P19/02 , A23L33/105
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Patent Agency Ranking
公开(公告)号：KR101502773B1
公开(公告)日：2015-03-24
申请号：KR1020130088003
申请日：2013-07-25
Applicant: 조선대학교산학협력단
Abstract: 본 발명은 한국 전통 발효 식품인 김치에서 분리한 바실러스 균주에 의해 생산되고, 항균 및 항염증성의 양기능성 펩타이드 및 그의 용도에 관한 것이다. 본 발명에 따른 양기능성 펩타이드는 바실러스 속 CS32(균주기탁번호 KCTC 18250P)는 김치로부터 분리하고, 90 ℃ 이하 및 pH 5.0-12.0에서 안정된 것으로서, 메티실린 내성 황색포도상구균(MRSA), 반코마이신 내성 황색포도상구균 (VRSA) 및 반코마이신 내성 엔테로코시(VRE)를 포함하는 다약제 내성(MDR) 세균에 대해 항생 활성을 나타냄과 동시에 LPS에 의해 유도된 iNOS 및 COX-2 유전자 및 단백질 발현, 사이토카인 생산을 억제하는 항염증 작용을 나타내므로, 상기 펩타이드는 항생제 또는 항염증제로서 효율적으로 사용될 가능성이 매우 높다.
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公开(公告)号：KR1020120081048A
公开(公告)日：2012-07-18
申请号：KR1020120056692
申请日：2012-05-29
Applicant: 조선대학교산학협력단
Abstract: PURPOSE: A method for preparing thrombolytic enzyme derived from Streptomyces strain is provided to effectively treat and prevent thrombosis. CONSTITUTION: A method for preparing thrombolytic enzyme from Streptomyces sp. CS684(deposit number KCTC 10631 BP) comprises: a step of culturing the Streptomyces strain in a medium containing 10g of glucose, 15g of oat powder, 3g of K_2HPO_4, and 3g of NaH_2PO_4 at 28 Deg. C and 160 rpm for 48 hours; a step of centrifuging the culture liquid at 10,000 x g for 1 hour; a step of adding solid (NH_4)_2SO_4 to the supernatant to precipitate proteins; a step of performing dialysis of 10mM of Tris-HCl buffer solution(pH 7.5) and concentrating with ultrafiltration membrane YM30(Millipore Corp.); a step of performing gel permeation of the enzyme on a Sepharose CL-6B column (120 cm x 2.2 cm) to collect active fractions; a step of purifying the fraction using Poros-HQ ion exchange column(10 cm x 1 cm); and a step of eluting conjugated proteins using 10 mM Tris-HCl gradient buffer solution(pH 7.5) at 30ml/h.
Abstract translation: 目的：提供一种用于制备源自链霉菌属菌株的溶栓酶的方法，以有效治疗和预防血栓形成。 构成：从Streptomyces sp。制备溶栓酶的方法。 CS684（保藏号KCTC 10631 BP）包括：在含有10g葡萄糖，15g燕麦粉末，3g K_2HPO_4和3g NaH_2PO_4的培养基中培养Streptomyces菌株的步骤，28℃。 C和160rpm搅拌48小时; 将培养液以10,000×g离心1小时的步骤; 向上清液中加入固体（NH_4）_2SO_4沉淀蛋白质的步骤; 进行10mM Tris-HCl缓冲溶液（pH7.5）透析并用超滤膜YM30（Millipore Corp.）浓缩的步骤; 在Sepharose CL-6B柱（120cm×2.2cm）上进行酶的凝胶渗透以收集活性级分的步骤; 使用Poros-HQ离子交换柱（10cm×1cm）纯化级分的步骤; 和使用10mM Tris-HCl梯度缓冲溶液（pH7.5）以30ml / h洗脱缀合蛋白的步骤。
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公开(公告)号：KR1020110054964A
公开(公告)日：2011-05-25
申请号：KR1020090111798
申请日：2009-11-19
Applicant: 조선대학교산학협력단
CPC classification number: C12P17/16 , C07D493/10 , C12P17/181
Abstract: PURPOSE: A method for isolating and purifying antibacterial compounds from Nocardia strain is provided to optimally culture the strain and to purely isolate the compounds. CONSTITUTION: A method for fermenting, isolating, and purifying antibacterial compounds comprises: a step of centrifuging Nocardia sp. CS682 fermentation at 6,000 rpm and isolating bacteraia and supernatant of the culture liquid; a step of decompressing and concentrating the supernatant at 60-70°C; a step of isolating the culture with ethyl acetate twice or three times; a step of decompressing at 45-55°C; a step of loading the extract by silica column chromatography and fractioning with mixture of hexane and ethyl acetate in a ratio of 1:1-4:1; and a step of drying and isolating the antibacterial active compounds.
Abstract translation: 目的：提供从诺卡氏菌菌株分离和纯化抗菌化合物的方法，以最佳培养菌株并纯化该化合物。 构成：发酵，分离和纯化抗菌化合物的方法包括：将诺卡氏菌 CS682以6000rpm发酵，分离菌液和培养液上清液; 将上清液在60-70℃下减压浓缩的步骤; 用乙酸乙酯分离培养物两次或三次的步骤; 在45-55°C减压的步骤; 通过硅胶柱色谱法加载提取物并以1:4:1:1的比例用己烷和乙酸乙酯的混合物进行分级的步骤; 以及干燥和分离抗菌活性化合物的步骤。
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公开(公告)号：KR1020110054963A
公开(公告)日：2011-05-25
申请号：KR1020090111797
申请日：2009-11-19
Applicant: 조선대학교산학협력단
Abstract: PURPOSE: A Streptomyces sp.-derived fibrinolytic protease is provided to specifically lyze fibrin and to prevent and treat thrombosis. CONSTITUTION: A fibrinolytic protease is isolated from Streptomyces sp. CS684(deposit number KCTC 10631 BP). A thrombolytic agent contains the fibrinolytic protease. The fibrinolytic protease is used as a crude extract or by isolating. Diseases using the fibrinolytic protease are lung disease, renal diseases, and heart diseases. A pharmaceutical composition used as a thrombolytic agent contains pharmaceutical carrier.
Abstract translation: 目的：提供链霉菌衍生的纤维蛋白溶解蛋白酶，以特异性地溶解血纤蛋白并预防和治疗血栓形成。 构成：纤维蛋白溶解蛋白酶是从链霉菌分离出来的。 CS684（存款编号KCTC 10631 BP）。 溶栓剂含有纤维蛋白溶解性蛋白酶。 纤维蛋白溶解性蛋白酶用作粗提物或通过分离。 使用纤维蛋白溶解性蛋白酶的疾病是肺部疾病，肾脏疾病和心脏病。 用作血栓溶解剂的药物组合物含有药物载体。
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公开(公告)号：KR101885097B1
公开(公告)日：2018-08-03
申请号：KR1020160157878
申请日：2016-11-25
Applicant: 조선대학교산학협력단
IPC: C07K14/32 , A23L3/3463 , A61K38/16
CPC classification number: Y02A50/481
Abstract: 본발명은바실러스테퀴렌시스 K1R 유래의항균성펩타이드및 그의용도에관한것이다. 본발명에따른펩타이드 K1R은다양한다약제내성 (MDR) 병원균에대하여, 특히, 반코마이신내성그룹의생물체에대하여반코마이신및 바시트라신보다양호한결과를나타내었다.및sp.등의 MDR 병원체에대한그의길항효과는 K1R이감염성 MDR 경우를치료함에있어서그의잠재적인응용성을가짐을확인하였다. K1R의항산화활성은또한표준아스코르브산의것에필적하였다. 따라서, 본발명의바실러스테퀴렌시스 K1R 유래의항균성펩타이드는종래의항균제에비하여뛰어난항균특성을지니므로항균용및 항산화용약학조성물의유효성분으로유용하게사용될수 있다.
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