Abstract:
본 발명은 SIVmac239/레수스원숭이(rhesus macaque) 모델에서 면역화에 의해 SIVmac239의 점막 감염 후 바이러스증식 억제 효능을 가진 플라미드 및 재조합 아데노바이러스에 관한 것이다. 또한, 본 발명은 상기 면역원성 플라스미드 및 재조합 아데노바이러스 를 포함하는 AIDS 예방 또는 치료용 백신, 및 상기 백신을 이용하는 프라이밍-부스팅 면역화 기법에 관한 것이다. AIDS, 재조합 아데노바이러스, 면역원성 플라스미드, SIVmac239, 점막감염, 면역증강물질, 프라이밍-부스팅, 면역화 기법
Abstract:
본 발명은 단백질 치료제의 방출율을 일정하게 제어하는 나노 다공성 박막을 이용한 인간 성장 호르몬-Fc 융합 단백질의 서방형 약물 전달 시스템에 관한 것이다. 본 발명에 따른 나노 구멍을 형성시킨 나노 다공성 박막은 치료용 단백질의 방출조절(controlled release) 및 화장품(cosmetic) 분야에서 기능성 단백질의 방출을 조절할 수 있는 디포 시스템(depot system)으로 블록 혼성 중합체(block copolymer) 기반의 나노 다공성 전달체(nanoporous carrier)로 사용할 수 있을 것으로 기대된다.
Abstract:
PURPOSE: A vector which contains and expresses BMP-2 and HSV-tK suicide gene and a stem cell therapeutic agent of self-regulation in which the vector is introduced are provided to remove cancer occurrence possibility and to reduce in vivo immunodepression. CONSTITUTION: A DNA cassette comprises a nucleic acid sequence of BMP and nucleotide acid of suicide gene between transcription/translation initiator sequence. The BMP has a nucleic acid sequence of human BMP-2 of sequence number 1. The suicide gene is HSV-tk having a nucleic acid sequence of sequence number 3. An expression vector has the DNA cassette. A stem cell therapeutic agent of self-regulation contains mesenchymal stem cells as an active ingredient, obtained by proliferation of recombinant adenovirus-infected stem cells. The therapeutic agent is used for treating bone diseases.
Abstract:
PURPOSE: A novel biomarker for acute myeloid leukemia is provided to diagnose acute myeloid leukemia and neutralize by specifically binding to biomarker. CONSTITUTION: A biomarker for diagnosing acute myeloid leukemia contains TM6SF1(transmembrane 6 superfamily member 1) or TM7SF3(transmembrane 7 superfamily member 3) as an active ingredient. An extracellular domain of TM6SF1 specifically binds to anti-TM6SF1 antibody. The extracellular domain of TM6SF1 is encoded by a sequence of sequence number 5. An extracellular domain of TM7SF3 specifically binds to anti-TM7SF3 antibody. The extracellular domain of TM7SF3 is encoded by a sequence of sequence number 6.
Abstract:
A composition for improving gene transfer containing a recombinant adenovirus and DOTAP (1,2-dioleoyl-3-trimethylammonium propane) is provided to increase the gene transfer efficiency of recombinant adenovirus which expresses interleukin-12 mutant and have the excellent anticancer effect. A composition for enhancing gene transfer comprises a recombinant adenovirus and DOTAP(1,2-dioleoyl-3-trimethylammonium propane). The recombinant adenovirus expresses cytokine, chemokine, antigen, tumor suppressor gene, suicide gene, anti-angiogenic factor, prodrug activating gene or immunostimulatory gene.
Abstract:
본 발명은 생물학적 활성 분자 및 생물학적 활성 분자에 결합 되는 면역글로불린(Ig) Fc 도메인을 포함하는 융합 단백질에 관한 것이다. Fc 도메인은 (ⅰ) IgG1, IgG2 또는 IgG4 또는 (ⅱ) IgG4 및 IgD의 하이브리드 인간 Fc 도메인이다. 하이브리드 Fc는 생물학적 활성 분자의 담체로서 유용하다. 융합 단백질
Abstract:
The immunogenic plasmid of SIVmac239(Simian Immunodeficiency Virus) is provided to minimize the immunity disturbance activity of the supplementary gene and optimize the codon to increase the expression efficiency of the inserted gene, thereby increasing the expression efficiency and immune efficacy of immunogen. The plasmid comprises the gene vif derived from SIVmac239, the signal sequence of secretory protein which is linked to the 3'-terminal of the gene vif, and the gene nef derived from SIVmac239 linked to the 5-terminal of the gene vif.
Abstract:
PURPOSE: A composition comprising recombinant adenovirus and polycation with enhanced gene transfer efficiency is provided, thereby enhancing gene transfer, improving gene transduction and replicated amount of adenovirus within cells, so that effect of therapy can be improved. CONSTITUTION: The composition comprises recombinant adenovirus of which fiber is modified and polycation, wherein the recombinant adenovirus is AdG; and the polycation is polybrene, protamine sulfate, lipopectamine, DOTAP(1,2-dioleoyl-3- trimethylammonium-propane) and CaCl2, preferably protamine sulfate. A method for enhancing gene transfer efficiency of adenovirus comprises treating the recombinant adenovirus of which fiber is modified with polycation.
Abstract:
본 발명은 생물학적 활성 분자 및 생물학적 활성 분자에 결합 되는 면역글로불린(Ig) Fc 도메인을 포함하는 융합 단백질에 관한 것이다. Fc 도메인은 (ⅰ) IgG1, IgG2 또는 IgG4 또는 (ⅱ) IgG4 및 IgD의 하이브리드 인간 Fc 도메인이다. 하이브리드 Fc는 생물학적 활성 분자의 담체로서 유용하다. 융합 단백질