公开(公告)号：KR1020140118524A

公开(公告)日：2014-10-08

申请号：KR1020130034620

申请日：2013-03-29

Applicant: 포항공과대학교 산학협력단

Inventor： 박재성 ,  조원주 ,  김준호 ,  조시우 ,  정화평

IPC: C12M1/00

CPC classification number: G01N1/4077 ,  C12M33/14 ,  C12M47/06 ,  G01N2001/4083 ,  G01N2001/4088

Abstract: The present invention relates to an apparatus for manufacturing cell-derived artificial microvesicles and, more specifically, to an apparatus for manufacturing artificial microvesicles by a method of entering cells through a porous filter in a concentrated state by using a centrifugal force. The artificial microvesicles manufactured according to the present invention not only maintains structure of a cell membrane intactly, but also minimizes loss of cytoplasm by a buffer solution used during manufacturing to show properties of containing cytoplasm. Therefore, the microvesicles manufactured by using the apparatus of the present invention is expected to be used in not only a base research, but also an applied research such as disease diagnosis and drug delivery technology.

Abstract translation: 本发明涉及一种用于制造细胞衍生的人造微囊的装置，更具体地说，涉及一种通过使用离心力通过多孔过滤器以浓缩状态进入细胞的方法来制造人造微泡的装置。 根据本发明制造的人造微泡不仅保持了细胞膜的结构，而且还使制造过程中使用的缓冲溶液的细胞质损失最小化，以显示含有细胞质的性质。 因此，通过使用本发明的装置制造的微泡体不仅可用于基础研究，还可用于疾病诊断和药物输送技术等应用研究。