公开(公告)号：KR1020100085567A

公开(公告)日：2010-07-29

申请号：KR1020090004939

申请日：2009-01-21

Applicant: 한국과학기술연구원

Inventor： 김충 ,  강지윤 ,  김태송 ,  이수현

IPC: B01J13/02 ,  A61J3/00

CPC classification number: B01J13/04 ,  A61J3/00 ,  B01J8/1809

Abstract: PURPOSE: A three dimensional focusing flow guiding device, a manufacturing device of the microcapsules using the same, and a method therefor are provided to manufacture the microcapsules formed in a constant shape through three dimensional focusing flow guidance, and to stably progress a solidification process of the microcapsules. CONSTITUTION: A three dimensional focusing flow guiding device includes the following: a first fluid inlet part(110) supplying first fluid; a second fluid inlet part(120) equipped on a left and a right sides of the first fluid inlet part; and a fluid compaction part(130) consisting of minute channels and equipped on the rear of the first and the second fluid meeting points. The fluid compaction part includes each fluid compaction guide members on the bottom and the top of the minute channels.

Abstract translation: 目的：提供三维聚焦流引导装置，使用其的微胶囊的制造装置及其制造方法，其通过三维聚焦流引导制造形成为恒定形状的微胶囊，并且稳定地进行固化过程 微胶囊。 构成：三维聚焦流引导装置包括：第一流体入口部分（110），其供应第一流体; 设置在第一流体入口部分的左侧和右侧的第二流体入口部分（120）; 以及由第一和第二流体接合点的后部配备有微细通道的流体压实部件（130）。 流体压实部分包括在微通道的底部和顶部上的每个流体压实引导构件。

公开(公告)号：KR100942184B1

公开(公告)日：2010-02-11

申请号：KR1020080038546

申请日：2008-04-25

Applicant: 한국과학기술연구원

Inventor： 김충 ,  강지윤 ,  김태송

IPC: G01N35/00

CPC classification number: C12N11/04 ,  B01F3/0865 ,  C12M25/16

Abstract: 본 발명은 세포 분산화를 통해 마이크로 캡슐 내에 캡슐화되는 세포의 개수를 균일하게 재현할 수 있고, 유체 교환을 통해 마이크로 캡슐 내의 세포 활성도를 증가시킬 수 있으며, 마이크로 캡슐 크기를 일정하게 담보할 수 있는 마이크로 캡슐 제조장치 및 방법에 관한 것으로서, 본 발명에 따른 마이크로 캡슐 제조장치는 공간적으로 서로 연결되며, 특정 방향으로 유체가 흐르도록 설계된 복수의 미세 채널을 이용한 마이크로 캡슐 제조장치에 있어서, 세포와 세포 액적화 물질의 혼합 유체가 공급되는 세포 공급부 및 상기 복수의 미세 채널 중 어느 한 미세 채널을 통해 공급되는 액적 유도 유체와, 상기 세포와 세포 액적화 물질의 혼합 유체가 합류되어 액적이 형성되는 액적 생성부를 포함하여 이루어지는 것을 특징으로 한다.
마이크로캡슐, 마이크로비드, 미세채널, 세포분산, 액적생성

公开(公告)号：KR100915900B1

公开(公告)日：2009-09-07

申请号：KR1020080021648

申请日：2008-03-07

Applicant: 한국과학기술연구원

Inventor： 김충 ,  강지윤 ,  김태송

IPC: G01N35/00

Abstract: A linear diluting apparatus using a microchannel, and its method are provided to prepare a diluted solution of various concentration whose concentration is changed linearly by the one injection of sample. A linear diluting apparatus using a microchannel comprises a main channel(110) which provides the flowing space of a chemical solution and a buffer solution; and a plurality of branched channels(120) which are branched from the main channel with a constant interval along the length direction of the main chain. The length of the branched channels is set so as to allow the flux discharged from the main channel into the each branched channel to be identical. A linear diluting method comprises the steps of supplying a chemical solution and a buffer solution to the main channel to form a laminar flow; and flowing the chemical solution and the buffer solution along the main channel so as to increase the dilution ratio of the chemical solution and the buffer solution linearly in proportion to the length of the main channel.

Abstract translation: 提供使用微通道的线性稀释装置及其方法，以制备其浓度通过一次注射样品线性改变的各种浓度的稀释溶液。 使用微通道的线性稀释装置包括提供化学溶液和缓冲溶液的流动空间的主通道（110） 以及沿着主链的长度方向以一定间隔从主通道分支的多个分支通道（120）。 分支通道的长度被设定为允许从主通道排放到每个分支通道中的通量相同。 线性稀释法包括向主通道供给化学溶液和缓冲溶液以形成层流的步骤; 并使化学溶液和缓冲溶液沿着主通道流动，以使化学溶液和缓冲溶液的稀释比例与主通道的长度成比例地直线地增加。

公开(公告)号：KR1020060110919A

公开(公告)日：2006-10-26

申请号：KR1020050032696

申请日：2005-04-20

Applicant: 한국과학기술연구원

Inventor： 이강선 ,  김충 ,  채수경 ,  이진우 ,  김태송 ,  강지윤 ,  주병권 ,  이승기

IPC: C08J5/00 ,  C08J5/02

Abstract: A method for fabricating a microchannel using surface tension is provided to obtain microchannels having various sectional shapes such as circular and ellipsoidal shapes, to prevents microchannels from chemical contamination, and to allow the use of the microchannels in the field of bioengineering or sensor engineering. The method for fabricating a microchannel by using a surface tension between a liquid polymer and a solid polymer comprises the use of a liquid polymer and a solid polymer selected in such a manner that the adhesion between the liquid polymer and the solid polymer is greater than the cohesion inside the liquid polymer. The method comprises a step of solidifying the liquid polymer while the liquid polymer is attached to a wall surface of the solid polymer.

Abstract translation: 提供使用表面张力制造微通道的方法，以获得具有各种截面形状的微通道，例如圆形和椭圆形，以防止微通道被化学污染，并允许在生物工程或传感器工程领域使用微通道。 通过使用液体聚合物和固体聚合物之间的表面张力来制造微通道的方法包括使用液体聚合物和固体聚合物，所述液体聚合物和固体聚合物以使得液体聚合物和固体聚合物之间的粘合力大于 液体聚合物内的内聚力。 该方法包括在将液体聚合物附着在固体聚合物的壁表面上时使液体聚合物固化的步骤。