公开(公告)号：KR1020140028430A

公开(公告)日：2014-03-10

申请号：KR1020120094676

申请日：2012-08-29

Applicant: 나노바이오시스 주식회사 ,  한국과학기술원

Inventor： 김성우 ,  박현규 ,  김덕중 ,  원병연 ,  백송이

IPC: G01N27/30 ,  C12Q1/68 ,  G01N27/416

CPC classification number: C12Q1/686 ,  B01L7/525 ,  B01L2300/087 ,  B01L2300/1805 ,  B01L2300/185 ,  C12Q1/68 ,  G01N27/3278 ,  C12Q2561/113 ,  C12Q2565/501 ,  C12Q2565/631

Abstract: An embodiment of the present invention relates to a real-time PCR device, having a block of repetitiously arranged heater units, for detecting electrochemical signals, and a real-time PCR method using the same. According to the embodiment of the present invention, the device not only analyzes multiple samples at a high speed via the block of repetitiously arranged heater units and PCR chips in a shape of a panel at the same time, but also contributes significantly to the micro-miniaturization and enhanced portability of products by simple modularization allowing the easy detection of continuous electrochemical signals generated in the process of nucleic acid amplification.

Abstract translation: 本发明的实施例涉及一种实时PCR装置，其具有用于检测电化学信号的重复布置的加热器单元的块，以及使用其的实时PCR方法。 根据本发明的实施例，该装置不仅通过重复排列的加热器单元块和PCR芯片同时以面板的形状分析多个样品，而且还显着地有助于微型显示器， 通过简单的模块化使产品的小型化和增强的便携性容易地检测在核酸扩增过程中产生的连续电化学信号。

公开(公告)号：KR1020140024732A

公开(公告)日：2014-03-03

申请号：KR1020120091222

申请日：2012-08-21

Applicant: 엘지전자 주식회사 ,  한국과학기술원

Inventor： 심봉주 ,  박현규 ,  원병연 ,  백송이 ,  김지태 ,  조성문

IPC: C12N15/11 ,  C12N15/115 ,  C12Q1/68 ,  G01N27/26

CPC classification number: C12Q1/689 ,  C12Q1/6816 ,  C12Q1/686 ,  C12Q1/6876 ,  C12Q2525/301 ,  G01N27/26 ,  C12Q2525/205 ,  C12Q2563/113 ,  C12Q2563/137

Abstract: The present invention relates to a hairpin-type probe for detecting a target material, and a method for detecting the target material using the same. The hairpin-type probe for detecting the target material includes a loop with a target material recognizing portion, and a stem with an aptamer combined to an electrochemical signal material. The hairpin structure of the probe breaks when the probe is mixed with the target material, the signal material is separated from the aptamer to be freely moved to an electrode, and an electrochemical signal generated from the process changes for users to accurately detect the amount of the target material in real time. [Reference numerals] (200) Working electrode; (AA) Target nucleic acid; (BB) Electrochemical signal

Abstract translation: 本发明涉及一种用于检测目标材料的发夹型探针，以及使用其的目标材料的检测方法。 用于检测目标材料的发夹型探针包括具有靶材料识别部分的环和具有与电化学信号材料组合的适体的茎。 当探针与目标材料混合时，探针的发夹结构断裂，信号材料与适配器分离以自由移动到电极，并且由该过程产生的电化学信号改变，以便用户准确地检测 目标材料实时。 （附图标记）（200）工作电极; （AA）靶核酸; （BB）电化学信号

公开(公告)号：KR1020140010821A

公开(公告)日：2014-01-27

申请号：KR1020120077900

申请日：2012-07-17

Applicant: 나노바이오시스 주식회사 ,  한국과학기술원

Inventor： 김성우 ,  박현규 ,  이정환 ,  이유진 ,  김덕중 ,  원병연 ,  백송이

IPC: G01N27/26 ,  C12M3/00 ,  C12Q1/68 ,  G01N27/30

CPC classification number: B01L3/502715 ,  B01L7/52 ,  B01L2200/028 ,  B01L2200/10 ,  C12Q1/6825 ,  C12Q2561/113 ,  C12Q2563/137 ,  C12Q2565/607

Abstract: One embodiment of the present invention relates to a real-time PCR apparatus and a method thereof. According to the present invention, multiple samples are simultaneously analyzed with a dual row block and planar PCR chips at a very high speed, and realization of a simple module capable of easily detecting continuous electrochemical signals generated in the nucleic acid amplification process is able to contribute to ultra-miniaturization of an article and to making the article portable.

Abstract translation: 本发明的一个实施例涉及一种实时PCR装置及其方法。 根据本发明，以非常高的速度与双行块和平面PCR芯片同时分析多个样品，并且能够容易地检测在核酸扩增过程中产生的连续电化学信号的简单模块的实现能够有助于 使物品超小型化，便于携带。