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公开(公告)号：KR1020140077746A
公开(公告)日：2014-06-24
申请号：KR1020120146855
申请日：2012-12-14
Applicant: 한국전자통신연구원
CPC classification number: C12M23/48 , G01N33/5005
Abstract: A cell culture apparatus according to an embodiment of the present invention comprises a fluid inlet; multiple cell culture tanks connected to the fluid inlet through fluid injection channels and in which a cellular reaction occurs as a material injected at the fluid inlet flows in; and multiple cell inlet arranged corresponding to the cell culture tanks, and connected to each cell culture tank through cell injection channels, to provide a cell to the cell culture tank.
Abstract translation: 根据本发明的实施方案的细胞培养装置包括流体入口; 多个细胞培养槽通过流体注入通道连接到流体入口，并且其中在流体入口处注入的材料流入细胞反应; 和多个细胞入口对应于细胞培养槽排列，并通过细胞注射通道连接到每个细胞培养槽，以向细胞培养罐提供细胞。
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公开(公告)号：KR1020140067888A
公开(公告)日：2014-06-05
申请号：KR1020130095485
申请日：2013-08-12
Applicant: 한국전자통신연구원
IPC: G01N35/08 , G01N33/49 , G01N33/543
CPC classification number: G01N35/085 , G01N33/492 , G01N33/54326 , G01N33/54346
Abstract: Provided are a multi-separation device and a manufacturing method thereof. According to the multi-separation device, magnetic force applied to target particles to be separated can be easily controlled for easy separation by optimally designing and arranging 3D fine ferromagnetic patterns. A method for manufacturing a multi-separation device according to another embodiment of the present invention enables precise manufacture using a semiconductor processing technology and is advantageous for mass production.
Abstract translation: 提供一种多分离装置及其制造方法。 根据多分离装置，通过最佳地设计和排列3D精细铁磁图案，可以容易地控制施加到待分离的目标颗粒上的磁力，从而容易分离。 根据本发明的另一实施例的多分离装置的制造方法能够使用半导体加工技术进行精确的制造，并且有利于批量生产。
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公开(公告)号：KR1020130066262A
公开(公告)日：2013-06-20
申请号：KR1020110133014
申请日：2011-12-12
Applicant: 한국전자통신연구원
Abstract: PURPOSE: An apparatus for culturing cells and analyzing cell response is provided to simultaneously measure different responses of each cell by a certain stimulant by infecting and culturing different cells in culture tanks. CONSTITUTION: An apparatus for culturing cells and analyzing cell response comprises a plurality of cell culture tanks, cell injection holes(10), and a reagent injection hole(30). The number of the cell injection holes is same as the number of the cell culture tanks. Each cell injection hole is connected to the cell culture tanks and each cell injection hole channel. The reagent injection hole is used for injecting a reagent into the cell culture tanks. A method for analyzing cell response comprises: a step of injecting predetermined different cells to the cell culture tanks; a step of injecting a culture medium to the cell culture tanks and culturing the cells; and a step of injecting same stimulant to each cell culture tank.
Abstract translation: 目的：提供培养细胞和分析细胞应答的装置，通过感染和培养培养罐中的不同细胞来同时测量某些兴奋剂对每个细胞的不同反应。 构成：用于培养细胞和分析细胞应答的装置包括多个细胞培养槽，细胞注入孔（10）和试剂注入孔（30）。 细胞注射孔的数量与细胞培养槽的数量相同。 每个细胞注入孔连接到细胞培养槽和每个细胞注入孔通道。 试剂注入孔用于将试剂注入细胞培养槽。 用于分析细胞应答的方法包括：将预定的不同细胞注入细胞培养槽的步骤; 将培养基注射到细胞培养槽中并培养细胞的步骤; 以及向每个细胞培养罐注入相同兴奋剂的步骤。
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公开(公告)号：KR1020110037345A
公开(公告)日：2011-04-13
申请号：KR1020090094748
申请日：2009-10-06
Applicant: 한국전자통신연구원
CPC classification number: C12M47/06 , B01L3/502761 , B01L2200/0652 , B01L2200/0668 , B01L2300/0864 , B01L2400/0487 , B01L2400/086 , C12M23/16
Abstract: PURPOSE: An array device for single cell splitting is provided to easily move single cells into the other system and to enhance cell survival rate. CONSTITUTION: An array device for single cell splitting comprises: a fluid channel having one or more spaces for separating the single cells contained in the fluid; an air valve channel for controlling fluid flow; a pressurizing channel for splitting separated single cells; and a cell trap structure which is mounted inside the space of the fluid channel and separates single cells contained in the fluid. A unit cell(100) of the device comprises: a sub-fluid channel(110), a sub-air valve channel(120) placed at the upper portion of the sub-fluid channel; and a polymer layer(101,102).
Abstract translation: 目的：提供用于单细胞分裂的阵列装置，以容易地将单细胞移动到另一系统中并增强细胞存活率。 构成：用于单细胞分解的阵列装置包括：具有一个或多个空间的流体通道，用于分离容纳在流体中的单个细胞; 用于控制流体流动的空气阀通道; 用于分离分离的单细胞的加压通道; 以及安装在流体通道的空间内并分离容纳在流体中的单个细胞的细胞捕获结构。 装置的单元电池（100）包括：副流体通道（110），置于子流体通道上部的副空气阀通道（120） 和聚合物层（101,102）。
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Patent Agency Ranking
公开(公告)号：KR1020130103282A
公开(公告)日：2013-09-23
申请号：KR1020120116207
申请日：2012-10-18
Applicant: 한국전자통신연구원
CPC classification number: B03C1/32 , B03C1/0332 , G01N33/50
Abstract: PURPOSE: A demultiplexer and a method for separating cancer cell from blood are provided to separate cancer cells according to the kind of cancer by controlling magnetic force of ferromagnetism pattern or its flux after putting blood sample in a micro channel. CONSTITUTION: A demultiplexer (100) comprises: a channel (2) in which mixed liquid flows; and a ferromagnetism pattern (3) arranged under the bottom surface of the channel. The flux of the mixed liquid, or the magnetic force of the ferromagnetism pattern are changed according to the direction of the channel. A method for separating cancel cell from blood comprises the steps of: manufacturing mixed liquid comprising cancer cells combined with magnetic nano particle by mixing object blood with the magnetic nano particle which is combined with antibody specifically reacting with the cancer cell; putting the mixed liquid in the channel of which the ferromagnetism patterns are arranged on the bottom surface; and catching the cancer cells according to the kind by controlling the flux of the mixed liquid, or changing the magnetic force of the ferromagnetism pattern in the channel.
Abstract translation: 目的：提供多路分解器和从血液中分离癌细胞的方法，通过在将血液样本置入微通道后控制铁磁图案或其通量的磁力，根据癌症的种类分离癌细胞。 构成：解复用器（100）包括：混合液体流过的通道（2）; 以及布置在通道的底表面下方的铁磁图案（3）。 混合液体的通量或铁磁性图案的磁力根据通道的方向而改变。 一种从血液中分离灭活细胞的方法包括以下步骤：通过将目标血液与与癌细胞特异性反应的抗体组合的磁性纳米颗粒混合制备包含与磁性纳米颗粒结合的癌细胞的混合液体; 将混合液体放置在底面上布置有铁磁图案的通道中; 并通过控制混合液体的通量或改变通道中铁磁性图案的磁力，根据种类捕获癌细胞。
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公开(公告)号：KR101252829B1
公开(公告)日：2013-04-11
申请号：KR1020090094748
申请日：2009-10-06
Applicant: 한국전자통신연구원
CPC classification number: C12M47/06 , B01L3/502761 , B01L2200/0652 , B01L2200/0668 , B01L2300/0864 , B01L2400/0487 , B01L2400/086 , C12M23/16
Abstract: 본 발명은 단일세포 분주용 어레이 장치에 관한 것으로, 유체에 포함된 단일세포를 분리하기 위한 하나 이상의 공간이 형성된 유체채널; 상기 유체채널에 형성된 공간의 입구 및 출구의 상부에 위치하여 상기 유체채널 내의 유체 흐름을 제어하기 위한 공기밸브채널; 상기 유체채널에 형성된 공간의 상부에 위치하여 상기 공간에서 분리된 단일세포를 분주하기 위한 가압채널; 및 상기 유체채널에 형성된 공간의 내부에 설치되어 상기 유체채널을 흐르는 유체에 포함된 단일세포를 분리하는 세포 트랩용 구조물을 포함하여 구성된다.
단일세포 분주, 어레이, 미소유체-
公开(公告)号：KR101810941B1
公开(公告)日：2017-12-20
申请号：KR1020130095485
申请日：2013-08-12
Applicant: 한국전자통신연구원
IPC: G01N35/08 , G01N33/49 , G01N33/543
Abstract: 본발명은다중분리장치및 이의제조방법을제공한다. 이다중분리장치에따르면, 3차원의미세한강자성패턴을최적설계및 배치하여, 분리하고자하는분리목표입자에가해지는자기력을분리가잘 되도록잘 조절할수 있다. 본발명의다른예에따른다중분리장치의제조방법은반도체공정기술을사용함으로써정밀한제조가가능하고대량생산에유리하다.
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公开(公告)号：KR1020170109740A
公开(公告)日：2017-10-10
申请号：KR1020160033515
申请日：2016-03-21
Applicant: 주식회사 지노바이오 , 한국전자통신연구원
IPC: B01L3/00
CPC classification number: B01L3/508 , B01L3/502753 , B01L2200/0652 , B01L2200/0668 , B01L2300/0809 , B01L2300/0816 , B01L2300/0848 , B01L2400/086
Abstract: 세포포획카트리지가제공된다. 본발명에따른세포포획카트리지는기판; 및상기기판의상면상에제공되며, 열방향과나란한복수의열들을구성하는구조체들을포함할수 있다. 열들중에서어느하나의열의구조체들은이웃한열의구조체들로부터상기열 방향으로오프셋될수 있다. 상기구조체들각각은상기기판의일 측을향하는제1 측면; 및상기제1 측면과대향되고, 상기제1 측면보다넓은너비를갖는제2 측면을가질수 있다.
Abstract translation: 提供细胞捕获盒。 根据本发明的细胞捕获盒包括：基底; 以及设置在基板的上表面上并构成与列方向平行的多行的结构。 任何一列的结构可以在列方向上从相邻列的结构偏移。 每个结构具有面向衬底的一侧的第一侧; 并且第二侧面与第一侧面相对并且具有比第一侧面更宽的宽度。
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公开(公告)号：KR1020170104289A
公开(公告)日：2017-09-15
申请号：KR1020160027158
申请日：2016-03-07
Applicant: 한국전자통신연구원
IPC: G01N21/552 , G01N33/68 , G01N33/483 , G01N21/77
Abstract: 본발명은항원센서, 그를포함하는항원검출장치및 항원검출방법을개시한다. 그의장치는, 도파로및 상기도파로상의나노입자들을포함하는센서와, 상기도파로의일측으로광을제공하는광원과, 광원에대향하는도파로의타측에배치되어광을수광하는수광부와, 수광부에서수광되는광의검출신호를수신하고, 나노입자들의플라즈몬공명에따른도파로의차이를파악하여항원의감지를판별하는제어부를포함한다.
Abstract translation: 本发明公开了抗原传感器，包含其的抗原检测装置和抗原检测方法。 他的装置包括包含在波导的波导和纳米颗粒的传感器，以及一个光源，用于向波导的侧面提供光，它被布置在相对所述波导的至光源的另一侧，其由接收的光的光接收部和光接收部的光接收 以及控制器，用于接收光的检测信号并通过掌握由于纳米颗粒的等离子体共振引起的波导的差异来确定抗原的检测。
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