公开(公告)号：KR1020100093946A

公开(公告)日：2010-08-26

申请号：KR1020090013114

申请日：2009-02-17

Applicant: 순천대학교 산학협력단 ,  한국화학연구원

Inventor： 최상기 ,  이규양 ,  백형록 ,  오재현 ,  정상철 ,  김낙정 ,  채종학 ,  김선우

IPC: C07D261/20 ,  C07D263/54

Abstract: PURPOSE: A fluorophenyl benzoxazole derivative with antifungal activity is provided to selectively suppress protein synthesis of pathogenic fungus and to use as an antifungal agent. CONSTITUTION: A fluorophenyl benzoxazole derivative or pharmaceutically acceptable salt thereof is denoted by chemical formula 1. The fluorophenyl benzoxazole derivatie is 3-[2-(4-fluorophenyl)-6-methyl-benzoxazole-5-yl]-3-oxo-propyonic acid methylester; 1-(2-(4-fluorophenyl)-6-methylbenzo[d]oxazole-5-yl)hexane-1,5-dion; 3-(2-(4-fluorophenyl)-6-methylbenzo[d]oxazole-5-yl)-3-oxopropionic acid ethyl ester; or 3-(6-ethyl-2-(4-fluorophenyl)benzo[d]oxazole-5-yl)-3-oxopropionic acid methyl ester. The compound of chemical formula 1 is prepared by reacting the compound of chemical formula 3 with a compound of chemical formula 2.

Abstract translation: 目的：提供具有抗真菌活性的氟苯基苯并恶唑衍生物，以选择性抑制病原真菌的蛋白质合成并用作抗真菌剂。 构成：氟苯并苯并恶唑衍生物或其药学上可接受的盐由化学式1表示。氟苯基苯并恶唑衍生物是3- [2-（4-氟苯基）-6-甲基 - 苯并恶唑-5-基] -3-氧代 - 丙基 酸甲酯; 1-（2-（4-氟苯基）-6-甲基苯并[d]恶唑-5-基）己烷-1,5-二酮; 3-（2-（4-氟苯基）-6-甲基苯并[d]恶唑-5-基）-3-氧代丙酸乙酯; 或3-（6-乙基-2-（4-氟苯基）苯并[d]恶唑-5-基）-3-氧代丙酸甲酯。 化学式1的化合物通过使化学式3的化合物与化学式2的化合物反应来制备。