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公开(公告)号：EP1042340B1
公开(公告)日：2004-09-22
申请号：EP98958055.0
申请日：1998-11-17
Applicant: Abbott Laboratories
Inventor： MONTGOMERY, Stephen, H. , LIU, Jih-Hua
CPC classification number: C07H17/08
Abstract: A process of preparing a 6-O-alkyl derivative of 9-oxime erythromycin B is provided. Intermediates used in the preparation of a 6-O-alkyl 9-oxime erythromycin B are also provided. Pharmaceutical compositions containing a 6-O-alkyl derivative of 9-oxime erythromycin B and the use of those compositions to treat bacterial infections are also provided.
Abstract translation: 提供了制备9-肟红霉素B的6-O-烷基衍生物的方法。 还提供了用于制备6-O-烷基9-肟红霉素B的中间体。 还提供了含有9-肟红霉素B的6-O-烷基衍生物的药物组合物以及这些组合物用于治疗细菌感染的用途。
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公开(公告)号：EP1040107B1
公开(公告)日：2003-01-29
申请号：EP98959480.9
申请日：1998-11-17
Applicant: Abbott Laboratories
Inventor： GRACEY, Howard, E. , MONTGOMERY, Stephen, H. , RILEY, David, A. , LIU, Jih-Hua
IPC: C07D313/00
CPC classification number: C07D313/00
Abstract: Novel 6-O-alkyl derivatives of erythronolide B are provided. A process for the preparation of 6-O-alkyl derivatives of erythronolide B using erythromycin B is also provided. A process for preparing 6-O-alkyl derivatives of erythromycin C using novel 6-O-alkyl derivatives of erythronolide B is further provided.
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13.发明授权2'-PROTECTED 3'-DIMETHYLAMINE, 9-ETHEROXIME ERYTHROMYCIN A DERIVATIVES 无效2'-PROTECTED 3'-二甲胺，9-肟醚红霉素A衍生物
公开(公告)号：EP0891370B1
公开(公告)日：2002-12-04
申请号：EP97905824.5
申请日：1997-02-06
Applicant: Abbott Laboratories
Inventor： YANG, Chengxi , PATEL, Hemantkumar, H. , KU, Yi-Kin , LIU, Jih-Hua
IPC: C07H17/08
Abstract: A process of preparing a 6-O-methyl erythromycin A derivative using a 2'-protected, 9-etheroxime erythromycin A intermediate is provided. A preferred protecting group for the 2'-position is acetyl. 2'-protected, 9-etheroxime erythromycin A derivatives are also provided. Also disclosed is a method for inhibiting quaternary salt formation at the 3' amine without the need for 3'N-protecting groups.
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公开(公告)号：EP0882024B1
公开(公告)日：2002-02-06
申请号：EP96944941.2
申请日：1996-12-06
Applicant: Abbott Laboratories
Inventor： SHAM, Hing, Leung , NORBECK, Daniel, W. , CHEN, Xiaoqi , BETEBENNER, David, A. , KEMPF, Dale, J. , HERRIN, Thomas, R. , KUMAR, Gondi, N. , CONDON, Stephen, L. , COOPER, Arthur, J. , DICKMAN, Daniel, A. , HANNICK, Steven, M. , KOLACZKOWSKI, Lawrence , OLIVER, Patricia, A. , PLATA, Daniel, J. , STENGEL, Peter, J. , STONER, Eric, J. , TIEN, Jieh-Heh, J. , LIU, Jih-Hua , PATEL, Ketan, M.
IPC: C07D239/10 , C07D239/22 , C07D207/26 , C07D241/08 , C07D263/22 , C07D233/32 , C07D207/40 , A61K31/415
CPC classification number: C07D207/27 , C07D207/404 , C07D207/408 , C07D223/10 , C07D233/32 , C07D233/42 , C07D239/10 , C07D239/22 , C07D241/08 , C07D241/18 , C07D253/06 , C07D263/22 , C07D307/20 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D407/12 , C07D409/12 , C07D409/14 , C07D417/12
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公开(公告)号：EP1077988A1
公开(公告)日：2001-02-28
申请号：EP97951771.1
申请日：1997-12-19
Applicant: Abbott Laboratories
Inventor： SPANTON, Stephen, G. , HENRY, Rodger, F. , RILEY, David, A. , LIU, Jih-Hua
CPC classification number: C07H17/08
Abstract: The present invention concerns the novel antibiotic 6-O-methylerythromycin A form 0 solvate of formula (I), a process for its preparation, pharmaceutical compositions comprising this compound and a method of use as a therapeutic agent.
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Patent Agency Ranking
公开(公告)号：EP1040107A1
公开(公告)日：2000-10-04
申请号：EP98959480.9
申请日：1998-11-17
Applicant: Abbott Laboratories
Inventor： GRACEY, Howard, E. , MONTGOMERY, Stephen, H. , RILEY, David, A. , LIU, Jih-Hua
IPC: C07D313/00
CPC classification number: C07D313/00
Abstract: Novel 6-O-alkyl derivatives of erythronolide B are provided. A process for the preparation of 6-O-alkyl derivatives of erythronolide B using erythromycin B is also provided. A process for preparing 6-O-alkyl derivatives of erythromycin C using novel 6-O-alkyl derivatives of erythronolide B is further provided.
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公开(公告)号：EP0915898B1
公开(公告)日：2003-12-03
申请号：EP97934307.6
申请日：1997-07-25
Applicant: Abbott Laboratories
Inventor： LIU, Jih-Hua , RILEY, David, A. , SPANTON, Stephen, G.
IPC: C07H17/08
CPC classification number: C07H17/08
Abstract: The present invention concerns the novel antiobiotic 6-O-methylerythromycin A crystal Form I, a process for its preparation, pharmaceutical compositions comprising this compound and a method of use as a therapeutic agent.
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公开(公告)号：EP0915899A1
公开(公告)日：1999-05-19
申请号：EP97934319.0
申请日：1997-07-28
Applicant: Abbott Laboratories
Inventor： LIU, Jih-Hua , RILEY, David, A.
CPC classification number: C07H17/08
Abstract: The present invention provides a process for the preparation of 6-O-methylerythromycin A Form II comprising converting erythromycin A to 6-O-methylerythromycin A and treating the 6-O-methylerythromycin A with a number of common organic solvents or mixtures of common organic solvents.
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公开(公告)号：EP0915898A1
公开(公告)日：1999-05-19
申请号：EP97934307.0
申请日：1997-07-25
Applicant: Abbott Laboratories
Inventor： LIU, Jih-Hua , RILEY, David, A. , SPANTON, Stephen, G.
CPC classification number: C07H17/08
Abstract: The present invention concerns the novel antiobiotic 6-O-methylerythromycin A crystal Form I, a process for its preparation, pharmaceutical compositions comprising this compound and a method of use as a therapeutic agent.
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20.发明公开2'-PROTECTED 3'-DIMETHYLAMINE, 9-ETHEROXIME ERYTHROMYCIN A DERIVATIVES 无效2'-PROTECTED 3'-二甲胺，9-肟醚红霉素A衍生物
公开(公告)号：EP0891370A1
公开(公告)日：1999-01-20
申请号：EP97905824.0
申请日：1997-02-06
Applicant: Abbott Laboratories
Inventor： YANG, Chengxi , PATEL, Hemantkumar, H. , KU, Yi-Kin , LIU, Jih-Hua
IPC: C07H17
Abstract: A process of preparing a 6-O-methyl erythromycin A derivative using a 2'-protected, 9-etheroxime erythromycin A intermediate is provided. A preferred protecting group for the 2'-position is acetyl. 2'-protected, 9-etheroxime erythromycin A derivatives are also provided. Also disclosed is a method for inhibiting quaternary salt formation at the 3' amine without the need for 3'N-protecting groups.
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