公开(公告)号：WO2012067824A1

公开(公告)日：2012-05-24

申请号：PCT/US2011/058953

申请日：2011-11-02

Applicant: ABBOTT LABORATORIES ,  PEREZ-MEDRANO, Arturo ,  PEDDI, Sridhar ,  DEGOEY, David

Inventor： PEREZ-MEDRANO, Arturo ,  PEDDI, Sridhar ,  DEGOEY, David

IPC: C07D239/92 ,  C07D495/04 ,  A61K31/517 ,  A61K31/519 ,  A61P25/00

CPC classification number: C07D495/04 ,  C07D239/92

Abstract: Disclosed herein are KCNQ potassium channels modulators of formula (I), wherein G 1 , R 2 , R 1a , R 1b , X, X 1 , X 2 , X 3 , R x , J, k, n, q, and t are as defined in the specification. Compositions comprising such compounds; and methods for treating conditions and disorders using such compounds and compositions are also described.

Abstract translation: 本文公开了式（I）的KCNQ钾通道调节剂，其中G1，R2，R1a，R1b，X，X1，X2，X3，Rx，J，k，n，q和t如本说明书中所定义。 包含这些化合物的组合物; 还描述了使用这些化合物和组合物治疗病症和病症的方法。

公开(公告)号：WO2010138828A2

公开(公告)日：2010-12-02

申请号：PCT/US2010/036596

申请日：2010-05-28

Applicant: ABBOTT LABORATORIES ,  SCANIO, Marc J. ,  BUNNELLE, William H. ,  CARROLL, William A. ,  PEDDI, Sridhar ,  PEREZ-MEDRANO, Arturo ,  SHI, Lei

Inventor： SCANIO, Marc J. ,  BUNNELLE, William H. ,  CARROLL, William A. ,  PEDDI, Sridhar ,  PEREZ-MEDRANO, Arturo ,  SHI, Lei

IPC: C07D239/92

CPC classification number: C07D239/92 ,  C07D405/12 ,  C07D495/04

Abstract: Disclosed herein are KCNQ potassium channels modulators of formula (I) wherein ring G 1 , X, R 1 , and R 2 are as defined in the specification. Compositions comprising such compounds; and methods for treating conditions and disorders using such compounds and compositions are also described.

Abstract translation: 本文公开了式（I）的KCNQ钾通道调节剂，其中环G1，X，R1和R2如说明书中所定义。 包含这些化合物的组合物; 还描述了使用这些化合物和组合物治疗病症和病症的方法。

公开(公告)号：WO2009114566A1

公开(公告)日：2009-09-17

申请号：PCT/US2009/036715

申请日：2009-03-11

Applicant: ABBOTT LABORATORIES ,  KOLASA, Teodozyi ,  FROST, Jennifer, M. ,  PATEL, Meena, V. ,  LATSHAW, Steven, P. ,  PEREZ-MEDRANO, Arturo ,  WANG, Xueqing ,  TIETJE, Karin, Rose, Marie ,  PEDDI, Sridhar ,  CARROLL, William, A.

Inventor： KOLASA, Teodozyi ,  FROST, Jennifer, M. ,  PATEL, Meena, V. ,  LATSHAW, Steven, P. ,  PEREZ-MEDRANO, Arturo ,  WANG, Xueqing ,  TIETJE, Karin, Rose, Marie ,  PEDDI, Sridhar ,  CARROLL, William, A.

IPC: C07D417/06 ,  A61K31/426

CPC classification number: C07D417/06

Abstract: Disclosed herein are compounds of formula (I) wherein R 1 , R 2 , R 3 , R 25a , R 26a , X, and n are as defined in the specification. Pharmaceutical compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and pharmaceutical compositions are also described.

Abstract translation: 本文公开了式（I）的化合物，其中R 1，R 2，R 3，R 25a，R 26a，X和n如说明书中所定义。 还描述了包含这些化合物的药物组合物，以及使用这些化合物和药物组合物治疗病症和病症的方法。

公开(公告)号：WO2009067613A1

公开(公告)日：2009-05-28

申请号：PCT/US2008/084216

申请日：2008-11-20

Applicant: ABBOTT LABORATORIES ,  FLORJANCIC, Alan, S. ,  DART, Michael, J. ,  RYTHER, Keith, B. ,  PEREZ-MEDRANO, Arturo ,  CARROLL, William, A. ,  PATEL, Meena, V. ,  TIETJE, Karin, Rosemarie ,  LI, Tongmei ,  KOLASA, Teodozyj ,  GALLAGHER, Megan, E. ,  PEDDI, Sridhar ,  FROST, Jennifer, M. ,  NELSON, Derek, W.

Inventor： FLORJANCIC, Alan, S. ,  DART, Michael, J. ,  RYTHER, Keith, B. ,  PEREZ-MEDRANO, Arturo ,  CARROLL, William, A. ,  PATEL, Meena, V. ,  TIETJE, Karin, Rosemarie ,  LI, Tongmei ,  KOLASA, Teodozyj ,  GALLAGHER, Megan, E. ,  PEDDI, Sridhar ,  FROST, Jennifer, M. ,  NELSON, Derek, W.

IPC: A01N43/42

CPC classification number: C07D417/12 ,  C07D277/46 ,  C07D417/06 ,  C07D513/04 ,  C07D513/20

Abstract: The present invention relates to compounds of formula (I), or pharmaceutical salts, prodrugs, salts of prodrugs, or combinations thereof, formula (I). wherein R 1 , R 2 , R 3 , R 4 , and L 1 are defined in the specfication, compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions. The present invention also relates to compounds of formula (II), or pharmaceutical salts, prodrugs, salts of prodrugs, or combinations thereof, formula (II). wherein R 1a , R 2a , R x , and n are as defined in the specification, compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions.

Abstract translation: 本发明涉及式（I）的化合物或其药物盐，前药，前药的盐或其组合，式（I）。 其中R1，R2，R3，R4和L1在具体实施方案中被定义，包含这些化合物的组合物以及使用这些化合物和组合物治疗病症和病症的方法。 本发明还涉及式（II）的化合物或其药物盐，前药，前药盐或其组合，式（II）。 其中R1a，R2a，Rx和n如说明书中所定义，包含这些化合物的组合物，以及使用这些化合物和组合物治疗病症和病症的方法。

公开(公告)号：WO2005111003A1

公开(公告)日：2005-11-24

申请号：PCT/US2005/014641

申请日：2005-04-28

Applicant: ABBOTT LABORATORIES ,  LI, Tongmei ,  CARROLL, William, A. ,  PEREZ-MEDRANO, Arturo ,  FLORJANCIC, Alan, S. ,  NELSON, Derek, W. ,  PEDDI, Sridhar ,  BUNNELLE, Eric, M. ,  HIRST, Gavin, C. ,  LI, Biqin

Inventor： CARROLL, William, A. ,  PEREZ-MEDRANO, Arturo ,  FLORJANCIC, Alan, S. ,  NELSON, Derek, W. ,  PEDDI, Sridhar ,  BUNNELLE, Eric, M. ,  HIRST, Gavin, C. ,  LI, Biqin

IPC: C07D257/06

CPC classification number: C07D487/04 ,  C07D257/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  C07D409/14 ,  C07D413/12 ,  C07D417/12 ,  C07D417/14 ,  C07D487/08 ,  C07D491/04 ,  C07D491/048 ,  C07D491/08

Abstract: A compound having Formula (I) or Formula (II) is disclosed as an P2X 7 antagonist, wherein A, B, C, Y, Y, Z, m, v, R 1 , R 2 , R 3 , R 4 , and R 5 , are as defined in the description. Methods and compositions for treating disease or condition modulated by P2X 7 are also disclosed.

Abstract translation: 公开了具有式（I）或式（II）的化合物作为P2X7拮抗剂，其中A，B，C，Y，Y，Z，m，v，R 1，R 2，R 3， R 4和R 5如说明书中所定义。 还公开了用于治疗由P2X7调节的疾病或病症的方法和组合物。

公开(公告)号：EP2376462A1

公开(公告)日：2011-10-19

申请号：EP09775056.6

申请日：2009-12-16

Applicant: Abbott Laboratories

Inventor： FROST, Jennifer, M. ,  LATSHAW, Steven, P. ,  DART, Michael, J. ,  CARROLL, William, A. ,  PEREZ-MEDRANO, Arturo ,  KOLASA, Teodozyj ,  PATEL, Meena ,  NELSON, Derek, W. ,  LI, Tongmei ,  PEDDI, Sridhar ,  WANG, Xueqing ,  LIU, Bo

IPC: C07D277/46 ,  C07D417/12 ,  C07D513/04 ,  A61K31/426 ,  A61K31/427 ,  A61K31/428 ,  A61P3/04 ,  A61P3/10 ,  A61P9/00 ,  A61P11/00 ,  A61P29/00 ,  A61P35/00

CPC classification number: C07D417/12 ,  C07D277/46 ,  C07D513/04

Abstract: Disclosed herein are cannabinoid receptor ligands of formula (I) wherein L
1 , A
1 , R
1g , z, R
2 , R
3 , and R
4 are as defined in the specification. Compositions comprising such compounds and methods for treating conditions and disorders using such compounds and compositions are also presented.

公开(公告)号：WO2012158399A1

公开(公告)日：2012-11-22

申请号：PCT/US2012/036918

申请日：2012-05-08

Applicant: ABBOTT LABORATORIES ,  BROWN, Brian S. ,  LI, Tongmei ,  PEDDI, Sridhar ,  PEREZ-MEDRANO, Arturo ,  DEGOEY, David

Inventor： BROWN, Brian S. ,  LI, Tongmei ,  PEDDI, Sridhar ,  PEREZ-MEDRANO, Arturo ,  DEGOEY, David

IPC: C07D237/32 ,  C07D237/34 ,  C07D401/04 ,  C07D401/06 ,  C07D405/04 ,  C07D405/12 ,  C07D405/14 ,  C07D409/04 ,  C07D413/12 ,  A61K31/502 ,  A61P25/06 ,  A61P25/08 ,  A61P25/18 ,  A61P25/22

CPC classification number: C07D237/32 ,  C07D237/34 ,  C07D401/04 ,  C07D401/06 ,  C07D405/04 ,  C07D405/12 ,  C07D405/14 ,  C07D409/04 ,  C07D413/12

Abstract: Disclosed herein are KCNQ potassium channels modulators of formula (I) wherein ring G 1 , R 1 , and R 2 are as defined in the specification. Compositions comprising such compounds; and methods for treating conditions and disorders using such compounds and compositions are also described.

Abstract translation: 本文公开了式（I）的KCNQ钾通道调节剂，其中环G1，R1和R2如说明书中所定义。 包含这些化合物的组合物; 还描述了使用这些化合物和组合物治疗病症和病症的方法。

公开(公告)号：WO2010123838A2

公开(公告)日：2010-10-28

申请号：PCT/US2010/031660

申请日：2010-04-20

Applicant: ABBOTT LABORATORIES ,  PEDDI, Sridhar ,  PATEL, Meena V. ,  ROHDE, Jeffrey J.

Inventor： PEDDI, Sridhar ,  PATEL, Meena V. ,  ROHDE, Jeffrey J.

IPC: C07C261/04 ,  C07C257/14 ,  A61K31/26 ,  A61P3/10 ,  A61P25/00

CPC classification number: A61K31/26 ,  C07C257/14 ,  C07C257/16 ,  C07C261/04 ,  C07C311/46 ,  C07C317/30 ,  C07C327/42 ,  C07C2601/02 ,  C07C2601/04 ,  C07C2601/08 ,  C07C2601/18 ,  C07C2602/42 ,  C07C2602/44 ,  C07C2603/74 ,  C07C2603/97 ,  C07D207/277 ,  C07D211/14 ,  C07D213/24 ,  C07D213/26 ,  C07D213/74 ,  C07D231/12 ,  C07D239/42 ,  C07D257/04 ,  C07D261/08 ,  C07D277/42 ,  C07D295/14 ,  C07D307/46 ,  C07D401/12 ,  C07D403/12 ,  C07D417/12

Abstract: The present invention relates to inhibitors of 11- β-hydroxysteroid dehydrogenase type 1 enzyme and their use in treatment of non-insulin dependent type 2 diabetes, insulin resistance, obesity, lipid disorders, metabolic syndrome, central nervous system disorders, and diseases and conditions that are related to excessive glucocorticoids.

Abstract translation: 本发明涉及11-β-羟基类固醇脱氢酶1型酶的抑制剂及其在治疗非胰岛素依赖性2型糖尿病，胰岛素抵抗，肥胖症，脂质障碍，代谢综合征，中枢神经系统疾病和疾病和病症中的用途 这与过量的糖皮质激素有关。

公开(公告)号：WO2010054024A2

公开(公告)日：2010-05-14

申请号：PCT/US2009/063318

申请日：2009-11-04

Applicant: ABBOTT LABORATORIES ,  CARROLL, William, A. ,  KOLASA, Teodozyj ,  LI, Tongmei ,  NELSON, Derek, W. ,  PATEL, Meena, V. ,  PEDDI, Sridhar ,  PEREZ-MEDRANO, Arturo ,  WANG, Xuequing

Inventor： CARROLL, William, A. ,  KOLASA, Teodozyj ,  LI, Tongmei ,  NELSON, Derek, W. ,  PATEL, Meena, V. ,  PEDDI, Sridhar ,  PEREZ-MEDRANO, Arturo ,  WANG, Xuequing

IPC: C07D275/02 ,  C07D275/04 ,  C07D417/04 ,  C07D417/06 ,  C07D417/12 ,  C07D513/04 ,  C07D513/10 ,  A61K31/425 ,  A61P9/00 ,  A61P11/00 ,  A61P25/00 ,  A61P29/00 ,  A61P35/00 ,  A61P37/00

CPC classification number: C07D275/02 ,  C07D275/04 ,  C07D417/04 ,  C07D417/06 ,  C07D417/12 ,  C07D513/04 ,  C07D513/10 ,  Y02P20/582

Abstract: The present application relates to isothiazolylidene containing compounds of Formula (I) wherein R 1 , R 2 , R 3 , R 4 , and L are as defined in the specification, compositions comprising such compounds, and methods for treating conditions and disorders using such compounds and compositions.

Abstract translation: 本申请涉及含有异噻唑基的式（I）化合物，其中R 1，R 2，R 3，R 4和L如说明书中所定义，包含这些化合物的组合物，以及使用这些化合物和组合物治疗病症和障碍的方法。

公开(公告)号：WO2010033543A2

公开(公告)日：2010-03-25

申请号：PCT/US2009/057088

申请日：2009-09-16

Applicant: ABBOTT LABORATORIES ,  CARROLL, William A ,  DART, Michael J. ,  FROST, Jennifer M. ,  LATSHAW, Steven P. ,  KOLASA, Teodozyi ,  LI, Tongmei ,  PEDDI, Sridhar ,  LIU, Bo ,  PEREZ-MEDRANO, Arturo ,  PATEL, Meena ,  WANG, Xueqing ,  NELSON, Derek W.

Inventor： CARROLL, William A ,  DART, Michael J. ,  FROST, Jennifer M. ,  LATSHAW, Steven P. ,  KOLASA, Teodozyi ,  LI, Tongmei ,  PEDDI, Sridhar ,  LIU, Bo ,  PEREZ-MEDRANO, Arturo ,  PATEL, Meena ,  WANG, Xueqing ,  NELSON, Derek W.

IPC: C07D231/40 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D409/14 ,  C07D413/12 ,  C07D413/14

CPC classification number: C07D405/12 ,  C07D231/40 ,  C07D285/135 ,  C07D403/12 ,  C07D405/14 ,  C07D409/14 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12

Abstract: Disclosed herein are cannabinoid receptor ligands of formula (I), wherein A 1 , A 5 , R x , X 4 , and z are as defined in the specification. Compositions comprising such compounds, and methods for treating conditions and disorders using such compounds and compositions are also disclosed.

Abstract translation: 本文公开了式（I）的大麻素受体配体，其中A1，A5，Rx，X4和z如说明书中所定义。 还公开了包含这些化合物的组合物，以及使用这些化合物和组合物治疗病症和障碍的方法。