公开(公告)号：US20140194349A1

公开(公告)日：2014-07-10

申请号：US14204892

申请日：2014-03-11

Applicant: AbbVie Inc.

Inventor： David A. DeGoey ,  Charles A. Flentge ,  William J. Flosi ,  David J. Grampovnik ,  Dale J. Kempf ,  Larry L. Klein ,  Ming C. Yeung ,  John T. Randolph ,  Xiu C. Wang ,  Su Yu

IPC: C07D213/56 ,  A61K31/443 ,  A61K45/06 ,  A61K31/426 ,  C07D401/12 ,  C07D407/12 ,  A61K31/444 ,  A61K31/4418

CPC classification number: C07D213/56 ,  A61K31/426 ,  A61K31/4418 ,  A61K31/443 ,  A61K31/444 ,  A61K45/06 ,  C07C311/16 ,  C07D213/38 ,  C07D213/85 ,  C07D231/08 ,  C07D239/22 ,  C07D277/06 ,  C07D277/30 ,  C07D307/16 ,  C07D307/20 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D405/06 ,  C07D405/12 ,  C07D407/12 ,  C07D417/04 ,  C07D417/06 ,  C07D417/12 ,  C07D417/14 ,  C07D451/02 ,  C07D471/04 ,  C07D471/10 ,  C07D493/04 ,  C07F9/58 ,  C07F9/65515 ,  C07F9/65583 ,  C07K5/0207

Abstract: A compound of the formula is disclosed as an HIV protease inhibitor. Methods and compositions for inhibiting an HIV infection are also disclosed.

Abstract translation: 公开了式的化合物作为HIV蛋白酶抑制剂。 还公开了用于抑制HIV感染的方法和组合物。

公开(公告)号：US20130085142A1

公开(公告)日：2013-04-04

申请号：US13627541

申请日：2012-09-26

Applicant: AbbVie Inc.

Inventor： Tao Li ,  Sachin V. Patel ,  Richard J. Perner ,  John T. Randolph ,  Michael R. Schrimpf ,  Kevin R. Woller ,  Zhiren Xia ,  Qingwei Zhang

IPC: C07D487/04

CPC classification number: C07D487/04

Abstract: The present application relates to: (a) compounds of Formula (I): and salts thereof, wherein Z1, Z2, Z3, Z4, R1, R2, and R3 are as defined in the specification; (b) compositions comprising such compounds and salts; and (c) methods of use of such compounds, salts, and compositions, particularly use as calcium channel inhibitors.

Abstract translation: 本申请涉及：（a）式（I）的化合物及其盐，其中Z 1，Z 2，Z 3，Z 4，R 1，R 2和R 3如说明书中所定义; （b）包含这些化合物和盐的组合物; 和（c）使用这些化合物，盐和组合物的方法，特别是用作钙通道抑制剂。

公开(公告)号：US11149043B2

公开(公告)日：2021-10-19

申请号：US17227071

申请日：2021-04-09

Applicant: Calico Life Sciences LLC ,  AbbVie Inc.

Inventor： Michael J. Dart ,  Jennifer M. Frost ,  Yunsong Tong ,  Xiangdong Xu ,  Lei Shi ,  Kathleen Murauski ,  Marina Pliushchev ,  Brian S. Brown ,  Eric Voight ,  John T. Randolph

IPC: C07F9/12

Abstract: Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases, disorders and conditions.

公开(公告)号：US20210169892A1

公开(公告)日：2021-06-10

申请号：US16761354

申请日：2018-11-02

Applicant: Calico Life Sciences LLC ,  AbbVie Inc.

Inventor： Kathleen Ann Martin ,  Carmela Sidrauski ,  Jennifer M. Frost ,  Yunsong Tong ,  Xiangdong Xu ,  SeungWon Chung ,  Qingwei I. Zhang ,  Lei Shi ,  Kathleen J. Murauski ,  Michael J. Dart ,  John T. Randolph

IPC: A61K31/538 ,  A61K45/06 ,  C07D317/46 ,  C07D209/08 ,  C07D413/06 ,  C07D265/36 ,  C07D217/16 ,  C07D311/66 ,  C07D413/12 ,  C07D319/20 ,  C07D307/85 ,  C07D209/42 ,  C07D493/04 ,  C07D405/12 ,  C07C235/22 ,  A61K31/36 ,  A61K31/4045 ,  A61K31/472 ,  A61K31/353 ,  A61K31/357 ,  A61K31/343 ,  A61K31/404

Abstract: Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases, disorders and conditions.

公开(公告)号：US10668167B2

公开(公告)日：2020-06-02

申请号：US16408602

申请日：2019-05-10

Applicant: AbbVie Inc.

Inventor： Michael J. McPherson ,  Adrian D. Hobson ,  Martin E. Hayes ,  Christopher C. Marvin ,  Diana Schmidt ,  Wendy Waegell ,  Christian Goess ,  Jason Z. Oh ,  Axel Hernandez, Jr. ,  John T. Randolph

IPC: A61K47/68 ,  C07K16/24 ,  A61P37/06 ,  C07J71/00 ,  A61K39/00 ,  C07K16/18

Abstract: Provided herein are glucocorticoid receptor agonist immunoconjugates, glucocorticoid receptor agonists, and methods of using the same, e.g., to treat autoimmune or inflammatory diseases.

公开(公告)号：US09586978B2

公开(公告)日：2017-03-07

申请号：US14558318

申请日：2014-12-02

Applicant: AbbVie Inc.

Inventor： Mary E. Bellizzi ,  David A. Betebenner ,  Jean C. Califano ,  William A. Carroll ,  Daniel D. Caspi ,  David A. DeGoey ,  Pamela L. Donner ,  Charles A. Flentge ,  Yi Gao ,  Charles W. Hutchins ,  Douglas K. Hutchinson ,  Tammie K. Jinkerson ,  Warren M. Kati ,  Ryan G. Keddy ,  Allan C. Krueger ,  Wenke Li ,  Dachun Liu ,  Clarence J. Maring ,  Mark A. Matulenko ,  Christopher E. Motter ,  Lissa T. Nelson ,  Sachin V. Patel ,  John K. Pratt ,  John T. Randolph ,  Todd W. Rockway ,  Kathy Sarris ,  Michael D. Tufano ,  Seble H. Wagaw ,  Rolf Wagner ,  Kevin R. Woller

IPC: A61K38/00 ,  C07K16/00 ,  C07F7/02 ,  C07D401/14 ,  C07D403/14 ,  C07D405/14 ,  C07D413/14 ,  C07D417/14 ,  C07D453/00 ,  C07D491/113

CPC classification number: A61K31/454 ,  A61K31/4178 ,  A61K31/4184 ,  A61K31/422 ,  A61K31/435 ,  A61K31/4355 ,  A61K31/438 ,  A61K31/4418 ,  A61K31/4439 ,  A61K31/4545 ,  A61K31/496 ,  A61K31/506 ,  A61K31/5377 ,  A61K31/695 ,  A61K45/06 ,  C07D401/14 ,  C07D403/14 ,  C07D405/14 ,  C07D413/14 ,  C07D417/14 ,  C07D453/00 ,  C07D491/113 ,  C07F7/02 ,  Y02P20/582

Abstract: Compounds effective in inhibiting replication of Hepatitis C virus (“HCV”) are described. This invention also relates to processes of making such compounds, compositions comprising such compounds, and methods of using such compounds to treat HCV infection.

Abstract translation: 描述了有效抑制丙型肝炎病毒（“HCV”）复制的化合物。 本发明还涉及制备这种化合物的方法，包含这些化合物的组合物，以及使用这些化合物治疗HCV感染的方法。

公开(公告)号：US09382258B2

公开(公告)日：2016-07-05

申请号：US14693419

申请日：2015-04-22

Applicant: AbbVie Inc.

Inventor： Pramila A. Bhatia ,  John T. Randolph ,  Michael R. Schrimpf ,  Qingwei I. Zhang

IPC: C07D487/04

CPC classification number: C07D487/04

Abstract: This invention relates to: (a) compounds and salts thereof that, inter alia, treat pain; (b) intermediates useful for the preparation of such compounds and salts; (c) compositions comprising such compounds and salts; (d) methods for preparing such intermediates, compounds, salts, and compositions; (e) methods of use of such compounds, salts, and compositions; and (f) kits comprising such compounds, salts, and compositions.

公开(公告)号：US20140315792A1

公开(公告)日：2014-10-23

申请号：US14180886

申请日：2014-02-14

Applicant: AbbVie, Inc.

Inventor： Rolf Wagner ,  John K. Pratt ,  Dachun Liu ,  Michael D. Tufano ,  David A. DeGoey ,  Warren M. Kati ,  Charles W. Hutchins ,  Pamela L. Dooner ,  John T. Randolph ,  Christopher E. Motter ,  Lissa T. Nelson ,  Sachin V. Patel ,  Mark A. Matulenko ,  Ryan G. Keddy ,  Tammie K. Jinkerson ,  Todd W. Rockway ,  Clarence J. Maring ,  Douglas K. Hutchinson ,  Charles A. Flentge ,  David A. Betebenner ,  Kathy Sarris ,  Kevin R. Woller ,  Seble H. Wagaw ,  Jean C. Califano ,  Wenke Li ,  Daniel D. Caspi ,  Mary E. Bellizzi ,  Yi Gao ,  Allan C. Krueger

IPC: C07K5/06 ,  C07D417/14 ,  C07C33/26 ,  C07D403/14 ,  C07C205/19

CPC classification number: C07F9/65583 ,  C07C33/26 ,  C07C201/06 ,  C07C205/19 ,  C07D207/08 ,  C07D207/09 ,  C07D207/16 ,  C07D401/14 ,  C07D403/14 ,  C07D405/14 ,  C07D413/14 ,  C07D417/14 ,  C07D453/00 ,  C07D471/04 ,  C07D491/113 ,  C07K5/06

Abstract: Compounds effective in inhibiting replication of Hepatitis C virus (“HCV”) are described. This invention also relates to processes of making such compounds, compositions comprising such compounds, and methods of using such compounds to treat HCV infection.

公开(公告)号：US08669255B2

公开(公告)日：2014-03-11

申请号：US13627541

申请日：2012-09-26

Applicant: AbbVie Inc.

Inventor： Tao Li ,  Sachin V. Patel ,  Richard J. Perner ,  John T. Randolph ,  Michael R. Schrimpf ,  Kevin R. Woller ,  Zhiren Xia ,  Qingwei Zhang

IPC: A61K31/495

CPC classification number: C07D487/04

Abstract: The present application relates to: (a) compounds of Formula (I): and salts thereof, wherein Z1, Z2, Z3, Z4, R1, R2, and R3 are as defined in the specification; (b) compositions comprising such compounds and salts; and (c) methods of use of such compounds, salts, and compositions, particularly use as calcium channel inhibitors.

Abstract translation: 本申请涉及：（a）式（I）的化合物及其盐，其中Z 1，Z 2，Z 3，Z 4，R 1，R 2和R 3如说明书中所定义; （b）包含这些化合物和盐的组合物; 和（c）使用这些化合物，盐和组合物的方法，特别是用作钙通道抑制剂。

公开(公告)号：US08648074B2

公开(公告)日：2014-02-11

申请号：US13627536

申请日：2012-09-26

Applicant: AbbVie Inc.

Inventor： Tao Li ,  Sachin V. Patel ,  Richard J. Perner ,  John T. Randolph ,  Michael R. Schrimpf ,  Kevin R. Woller ,  Zhiren Xia ,  Qingwei Zhang

IPC: A61K31/495

CPC classification number: C07D487/04

Abstract: The present application relates to: (a) compounds of Formula (I): and salts thereof, wherein Z′, Z″, L2, G2, R1, and R2 are as defined in the specification; (b) compositions comprising such compounds and salts; and (c) methods of use of such compounds, salts, and compositions, particularly use as calcium channel blockers.

Abstract translation: 本申请涉及：（a）式（I）的化合物及其盐，其中Z'，Z“，L2，G2，R1和R2如说明书中所定义; （b）包含这些化合物和盐的组合物; 和（c）使用这些化合物，盐和组合物的方法，特别是用作钙通道阻滞剂。