公开(公告)号：EP4526681A1

公开(公告)日：2025-03-26

申请号：EP22942917.0

申请日：2022-05-20

Applicant: Academia Sinica

Inventor： YANG, An-Suei ,  YU, Chung-Ming ,  TUNG, Chao-Ping ,  HSU, Hung-Ju ,  PENG, Hung-Pin ,  CHEN, Chi-Yung ,  HUANG, Yu-Chuan ,  TSAI, Pei-Hsun ,  LIN, Szu-Yu ,  HUNG, Fei-Hung

IPC: G01N33/558 ,  C07K16/08

公开(公告)号：EP4504263A1

公开(公告)日：2025-02-12

申请号：EP23785543.2

申请日：2023-04-01

Applicant: Academia Sinica

Inventor： HSIEH, Shie-Liang ,  SUNG, Pei-Shan ,  YANG, An-Suei ,  YU, Chung-Ming

IPC: A61K39/395 ,  C07K16/00 ,  C07K16/28

公开(公告)号：EP4352092A2

公开(公告)日：2024-04-17

申请号：EP22820998.7

申请日：2022-06-08

Applicant: Academia Sinica

Inventor： YANG, An-Suei ,  HSU, Hung-Ju ,  TUNG, Chao-Ping ,  YU, Chung-Ming ,  CHEN, Chi-Yung ,  CHEN, Hong-Sen ,  HUANG, Yu-Chuan ,  TSAI, Pei-Hsun ,  LIN, Szu-Yu ,  PENG, Hung-Pin

IPC: C07K16/00 ,  C12N15/10 ,  C07K16/18 ,  C07K16/22 ,  C07K16/32

CPC classification number: C12N15/70 ,  C12N15/1037 ,  C40B40/08 ,  C07K2317/62220130101 ,  C07K16/005 ,  C07K16/30 ,  C07K2317/56520130101 ,  C07K2317/7320130101 ,  C07K2317/5220130101 ,  C07K2317/9420130101 ,  A61K2039/50520130101 ,  A61P35/00 ,  A61K47/6851 ,  A61K47/6849 ,  A61K47/68031

公开(公告)号：EP3856243A2

公开(公告)日：2021-08-04

申请号：EP19864483.3

申请日：2019-09-25

Applicant: Academia Sinica

Inventor： YANG, An-Suei ,  HSIEH, Shie-Liang ,  SUNG, Pei-Shan ,  HUANG, Ming-Ting ,  YU, Chung-Ming

IPC: A61K39/395 ,  A61P25/28 ,  C07K16/28

公开(公告)号：EP3697437A1

公开(公告)日：2020-08-26

申请号：EP18868719.8

申请日：2018-10-19

Applicant: Academia Sinica

Inventor： YANG, An-Suei ,  CHEN, Ing-Chien ,  CHIU, Yi-Kai ,  YU, Chung-Ming ,  LEE, Cheng-Chung ,  TUNG, Chao-Ping ,  TSOU, Yueh-Liang ,  HUANG, Yi-Jen ,  LIN, Chia-Lung ,  CHEN, Hong-Sen ,  WANG, Hwei-Jiung

IPC: A61K39/00 ,  C12N15/10

公开(公告)号：EP3514181A1

公开(公告)日：2019-07-24

申请号：EP19154062.4

申请日：2016-02-23

Applicant: Academia Sinica

Inventor： YANG, An-Suei ,  CHEN, Hong-Sen ,  CHEN, Ing-Chein ,  TUNG, Chao-Ping ,  HOU, Shin-Chen ,  YU, Chung-Ming ,  YANG, Chi-Kai ,  CHIU, Yi-Kai

IPC: C07K16/32 ,  C40B40/08 ,  C12N15/73 ,  C07K16/00 ,  C07K16/10 ,  C07K16/22 ,  C12N15/10 ,  C40B50/06

Abstract: Disclosed herein is a phage-displayed single-chain variable fragment (scFv) library, that comprised a plurality of phage-displayed scFvs characterized with (1) a specific CS combination; (2) a specific distribution of aromatic residues in each CDR; and (3) a specific sequence in each CDR. The present scFv library could be used to efficiently produce different antibodies with binding affinity to different antigens. Accordingly, the present disclosure provides a potential means to generate different antigen-specific antibodies promptly in accordance with the need in experimental researches and/or clinical applications.