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公开(公告)号：US20210108995A1
公开(公告)日：2021-04-15
申请号：US17129209
申请日：2020-12-21
Applicant: AGILENT TECHNOLOGIES, INC.
Inventor： Kyle Schleifer , Kristin Briana Bernick , Adrienne Mccampbell , Nicholas M. Sampas , Victor Lim
Abstract: The present disclosure is directed to an improved method for distinguishing tissue from an embedding medium, such as paraffin in a formalin-fixed paraffin-embedded sample. The method involves the use of fluorescence of naturally-occurring species in tissue to determine the location of the tissue in the embedded sample. An embedded sample is generally excited by light of a selected wavelength, and the fluorescence emission at an emitted wavelength is used to locate the boundary or location of the tissue in the embedded sample.
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公开(公告)号：US10760999B2
公开(公告)日：2020-09-01
申请号：US15882479
申请日：2018-01-29
Applicant: Agilent Technologies, Inc.
Inventor： Victor Lim
Abstract: Methods and apparatus are provided for transfer of a tissue section from a first location to a second location. Thermoplastic material is applied to at least one pin of a tissue section transferring apparatus. The thermoplastic material contacts a tissue section while at least partially melted, and when it cools, substantially solid thermoplastic material holds the tissue section to the at least one pin. A tissue section transferring apparatus comprises a heater block, a heat source, and at least one pin attached to and extending from the heater block.
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公开(公告)号：US20190323929A1
公开(公告)日：2019-10-24
申请号：US16392532
申请日：2019-04-23
Applicant: Agilent Technologies, Inc.
Inventor： Adrienne Mccampbell , Victor Lim
Abstract: Paraffin-embedded tissue is prepared removing paraffin from the tissue. The paraffin is removed by generating an electric field effective to produce plasma and direct charged species of the plasma to the paraffin, thereby rendering the paraffin responsive to the electric field. The electric field may move the paraffin out from the tissue due to electrostatic force. Movement of the paraffin may be assisted by moving an electrode utilized to generate the electric field relative to the paraffin. Movement of the paraffin also may be assisted by applying a solvent and/or heat energy to the tissue.
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公开(公告)号：US20240337570A1
公开(公告)日：2024-10-10
申请号：US18747240
申请日：2024-06-18
Applicant: Agilent Technologies, Inc.
Inventor： Adrienne McCampbell , Victor Lim
CPC classification number: G01N1/40 , G01N1/4022 , G01N1/44 , G01N2001/4038 , G02B21/34
Abstract: Paraffin-embedded tissue is prepared removing paraffin from the tissue. The paraffin is removed by generating an electric field effective to produce plasma and direct charged species of the plasma to the paraffin, thereby rendering the paraffin responsive to the electric field. The electric field may move the paraffin out from the tissue due to electrostatic force. Movement of the paraffin may be assisted by moving an electrode utilized to generate the electric field relative to the paraffin. Movement of the paraffin also may be assisted by applying a solvent and/or heat energy to the tissue.
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公开(公告)号：US20230236211A1
公开(公告)日：2023-07-27
申请号：US18001581
申请日：2021-06-11
Applicant: Agilent Technologies, Inc.
Inventor： Rolfe Anderson , Adrienne Mccampbell , Victor Lim , Carol T. Schembri , Michal Johannsen , Fleming Lassen Nielsen
CPC classification number: G01N35/00029 , G01N1/312 , G01N1/30 , G01N2035/00079 , G01N2035/00138 , G01N2035/00089 , G01N2035/00346 , G01N2001/305 , G01N2001/302
Abstract: Systems and methods for coverslipping a sample on a slide employ a coverslip tape. The systems and methods can reduce or eliminate the use of xylene and other toxic solvents for coverslipping.
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Patent Agency Ranking
公开(公告)号：US11243148B2
公开(公告)日：2022-02-08
申请号：US17129209
申请日：2020-12-21
Applicant: AGILENT TECHNOLOGIES, INC.
Inventor： Kyle Schleifer , Kristin Briana Bernick , Adrienne Mccampbell , Nicholas M. Sampas , Victor Lim
Abstract: The present disclosure is directed to an improved method for distinguishing tissue from an embedding medium, such as paraffin in a formalin-fixed paraffin-embedded sample. The method involves the use of fluorescence of naturally-occurring species in tissue to determine the location of the tissue in the embedded sample. An embedded sample is generally excited by light of a selected wavelength, and the fluorescence emission at an emitted wavelength is used to locate the boundary or location of the tissue in the embedded sample.
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公开(公告)号：US11073447B2
公开(公告)日：2021-07-27
申请号：US15445585
申请日：2017-02-28
Applicant: Agilent Technologies, Inc.
Inventor： Victor Lim , Kyle Schleifer , Russ Klein
Abstract: This invention is based, at least in part, on use of a tissue collector that reduces or eliminates manual steps in collecting and transferring tissue sections from a microtome to a slide. This invention relates to apparatus and methods for automated tissue sectioning, including slicing and transferring a tissue section from a microtome. The invention also relates to automated systems and methods for slicing and transferring a tissue section onto a slide.
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公开(公告)号：US20200264077A1
公开(公告)日：2020-08-20
申请号：US16868715
申请日：2020-05-07
Applicant: Agilent Technologies, Inc.
Inventor： Kyle Schleifer , Kristin Briana Bernick , Adrienne Mccampbell , Nicholas M. Sampas , Victor Lim
Abstract: The present disclosure is directed to an improved method for distinguishing tissue from an embedding medium, such as paraffin in a formalin-fixed paraffin-embedded sample. The method involves the use of fluorescence of naturally-occurring species in tissue to determine the location of the tissue in the embedded sample. An embedded sample is generally excited by light of a selected wavelength, and the fluorescence emission at an emitted wavelength is used to locate the boundary or location of the tissue in the embedded sample.
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公开(公告)号：US20190368982A1
公开(公告)日：2019-12-05
申请号：US15995755
申请日：2018-06-01
Applicant: Agilent Technologies, Inc.
Inventor： Kyle Schleifer , Kristin Briana Bernick , Adrienne Mccampbell , Nicholas M. Sampas , Victor Lim
Abstract: The present disclosure is directed to an improved method for distinguishing tissue from an embedding medium, such as paraffin in a formalin-fixed paraffin-embedded sample. The method involves the use of fluorescence of naturally-occurring species in tissue to determine the location of the tissue in the embedded sample. An embedded sample is generally excited by light of a selected wavelength, and the fluorescence emission at an emitted wavelength is used to locate the boundary or location of the tissue in the embedded sample.
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公开(公告)号：US20180120207A1
公开(公告)日：2018-05-03
申请号：US15797232
申请日：2017-10-30
Applicant: Agilent Technologies, Inc.
Inventor： Victor Lim , Carol T. Schembri , Adrienne Mccampbell , Nazumi Alice Yama-Dang
CPC classification number: G01N1/44 , G01N1/30 , G01N1/312 , G01N1/36 , G01N1/40 , G01N2001/366 , G01N2001/4038
Abstract: Paraffin-embedded tissue, which may be disposed on a solid substrate, is prepared by a dry technique that removes paraffin from tissue without adding any liquid to the tissue, thereby rendering the tissue substantially free of paraffin. The dry technique may entail applying heat energy to the tissue effective to melt the paraffin and thereby render it flowable, and applying an electric field. The electric field is effective to impart electrical charge to the paraffin and to move the paraffin out from the tissue due to electrical charge repulsion or attraction, which may be assisted by moving an electrode utilized to generate the electric field relative to the paraffin. The electric field, or both the electric field and the heat energy, may be applied until the tissue is substantially free of paraffin.
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