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公开(公告)号：WO2005110980A3
公开(公告)日：2005-11-24
申请号：PCT/US2005/012368
申请日：2005-04-14
Applicant: AMGEN, INC. , FAN, Pingchen , GOTO, Hiroyuki , HE, Xiao , KAKUTANI, Makoto , LABELLE, Marc , MCMINN, Dustin, L. , POWERS, Jay, P. , REW, Yosup , SUN, Daqing , YAN, Xuelei
Inventor： FAN, Pingchen , GOTO, Hiroyuki , HE, Xiao , KAKUTANI, Makoto , LABELLE, Marc , MCMINN, Dustin, L. , POWERS, Jay, P. , REW, Yosup , SUN, Daqing , YAN, Xuelei
IPC: C07C317/22
Abstract: Aryl sulfone compounds of formula (I) and (II) are described and have therapeutic utility, particularly in the treatment of diabetes, obesity and related conditions and disorders.
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公开(公告)号：EP1434579B1
公开(公告)日：2011-06-08
申请号：EP02769042.9
申请日：2002-10-09
Applicant: Amgen Inc.
Inventor： FRENKEL, Alexander David , LIVELY, Sarah Elizabeth , POWERS, Jay P. , SMITH, Andrew , SUN, Daqing , TOMOOKA, Craig , WANG, Zhulun
IPC: A61K31/4184 , A61K31/437 , A61K31/5355 , A61K31/45 , C07D235/30 , C07D471/04 , C07D405/12 , C07D409/12 , C07D403/06 , C07D401/06 , C07D403/12
CPC classification number: C07D249/08 , C07D231/12 , C07D233/56 , C07D235/30 , C07D401/06 , C07D403/04 , C07D403/06 , C07D403/12 , C07D405/12 , C07D409/12 , C07D471/04
Abstract: Compounds (I), pharmaceutical compositions thereof are provided that are useful in the treatment of inflammatory and immune-related conditions or disorders. In particular, the invention provides compounds which modulate the expression and/or function of proteins involved in inflammation, immune response regulation and cell proliferation. All definitions are as in the application.
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13.发明公开1-PHENYLSULFONYL-DIAZA HETEROCYCLIC AMIDE COMPOUNDS AND THEIR USES AS MODULATORS OF HYDROXSTEROID DEHYDROGENASES 审中-公开杂环1-苯磺酰基氮杂 - 酰胺化合物及其作为HYDROXSTEROID脱氢酶的调节剂的用途
公开(公告)号：EP2004619A1
公开(公告)日：2008-12-24
申请号：EP07753685.2
申请日：2007-03-22
Applicant: Amgen Inc.
Inventor： POWERS, Jay, P. , SUN, Daqing , YAN, Xuelei
IPC: C07D295/22 , C07D333/22 , C07D213/46 , A61K31/495 , A61K31/496 , A61P3/06 , A61P3/10 , A61P5/24 , A61P5/46 , A61P9/10 , C07D261/08 , C07D307/46 , C07D231/12 , C07D401/04
CPC classification number: C07D243/08 , C07D213/56 , C07D231/12 , C07D241/04 , C07D295/26 , C07D333/38
Abstract: Diaza heterocyclic amide derivatives according to Formula (I) have therapeutic utility, particularly in the treatment of diabetes, obesity and related conditions and disorders: (I) where R5,R6,R7,R8,R9,R10, m, Q, X, and Y are set forth in the description.
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14.发明公开
公开(公告)号：EP3762393A1
公开(公告)日：2021-01-13
申请号：EP19714512.1
申请日：2019-03-04
Applicant: Amgen Inc.
Inventor： RESCOURIO, Gwenaella , GONZALEZ BUENROSTRO, Ana , BROWN, Sean P. , LIZARZABURU, Mike , MEDINA, Julio C. , JABRI, Salman Yojiro , SUN, Daqing , SIMONOVICH, Scott Preston , YAN, Xuelei , LI, Yihong , REW, Yosup
IPC: C07D498/10 , C07D498/20 , A61P35/00 , A61K31/553 , C07D498/22
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15.发明授权BENZAMIDE DERIVATIVES AS MODULATORS OF 11BETA-HSD1 FOR TREATING DIABETES AND OBESITY 有权苯甲酰胺衍生物作为糖尿病和肥胖症的治疗11β-HSD1的调节剂
公开(公告)号：EP2044004B1
公开(公告)日：2012-08-15
申请号：EP07795530.0
申请日：2007-05-31
Applicant: Amgen Inc.
Inventor： POWERS, Jay, P. , DEGRAFFENREID, Michael , JULIAN, Lisa , KAIZERMAN, Jacob , MCMINN, Dustin , REW, Yosup , SUN, Daqing , YAN, Xuelei , WANG, Zhulun
IPC: C07C235/54 , C07D333/24 , C07D213/56 , C07D333/38 , C07D213/57 , A61K31/166 , C07D239/26 , A61K31/381 , C07D261/08 , A61K31/4406 , C07D273/08 , A61K31/415 , C07D307/94 , A61K31/4409
CPC classification number: C07C235/42 , A61K31/166 , A61K31/381 , A61K31/42 , A61K31/426 , A61K31/44 , A61K31/4965 , A61K31/50 , A61K31/505 , C07C237/22 , C07C237/24 , C07C237/42 , C07C255/31 , C07C255/46 , C07C255/60 , C07C271/12 , C07C271/20 , C07C307/06 , C07C2601/02 , C07C2601/14 , C07C2603/94 , C07D213/30 , C07D213/53 , C07D237/08 , C07D239/26 , C07D241/12 , C07D261/08 , C07D277/22 , C07D277/24
Abstract: Benzamide derivatives of formula ( I ) are described and have therapeutic utility, particularly in the treatment of diabetes, obesity and related conditions and disorders, formula (I), wherein R1, R 2, R 3, R 4, R 5, R 6, R 7, R 8, and n are as defined herein.
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Patent Agency Ranking
公开(公告)号：EP1904435A2
公开(公告)日：2008-04-02
申请号：EP06773288.3
申请日：2006-06-15
Applicant: Amgen Inc.
Inventor： POWERS, Jay P. , DEGRAFFENREID, Michael R. , HE, Xiao , JULIAN, Lisa , MCMINN, Dustin L. , SUN, Daqing , REW, Yosup , YAN, Xuelei
IPC: C07C235/42 , C07C237/22 , C07C255/24 , C07C255/31 , C07C255/44 , C07C255/46 , C07C255/60 , C07C317/36 , C07D211/16 , C07D211/18 , C07D211/22 , C07D211/34 , C07D211/38 , C07D211/52 , C07D211/60 , C07D211/64
CPC classification number: C07D277/28 , C07C235/42 , C07C235/54 , C07C237/42 , C07C255/29 , C07C255/31 , C07C255/44 , C07C255/46 , C07C255/60 , C07C317/36 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2602/42 , C07D211/16 , C07D211/18 , C07D211/22 , C07D211/34 , C07D211/38 , C07D211/52 , C07D211/60 , C07D211/64 , C07D213/40 , C07D213/61 , C07D213/74 , C07D213/81 , C07D213/84 , C07D213/89 , C07D233/64 , C07D295/192 , C07D307/22 , C07D309/14 , C07D333/20
Abstract: Benzamide derivatives of formulae I and II, and pharmaceutically acceptable salts, solvates, stereoisomers, and prodrugs thereof, and pharmaceutical compositions comprising the same, are described and have therapeutic utility, particularly in the treatment of diabetes, obesit and related conditions and disorders: wherein R1, R2, R3, R4, R5, R6, R7, R9, R10, Rll, and R12 are defined as provided herein.
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公开(公告)号：EP1735275A2
公开(公告)日：2006-12-27
申请号：EP05778401.9
申请日：2005-04-14
Applicant: Amgen Inc.
Inventor： FAN, Pingchen , GOTO, Hiroyuki, Centr. Pharm. Res. Inst. , HE, Xiao , KAKUTANI, Makoto, Centr. Pharm. Res. Inst. , LABELLE, Marc , MCMINN, Dustin, L. , POWERS, Jay, P. , REW, Yosup , SUN, Daqing , YAN, Xuelei
IPC: C07C317/22 , C07C317/14 , C07C317/44 , C07D215/36 , C07D233/54 , C07D295/10 , C07D277/36 , C07D277/54 , C07D277/56 , C07D333/34 , C07D333/38 , C07D417/04 , A61K31/10 , A61P3/04 , A61P3/10
CPC classification number: C07C317/44 , C07C317/14 , C07C317/22 , C07C2601/02 , C07D215/36 , C07D233/54 , C07D277/36 , C07D277/54 , C07D277/56 , C07D295/096 , C07D295/112 , C07D417/04
Abstract: Aryl sulfone compounds of formula (I) and (II) are described and have therapeutic utility, particularly in the treatment of diabetes, obesity and related conditions and disorders.
Abstract translation: 描述了式I和II的芳基砜化合物，并具有治疗效用，特别是在治疗糖尿病，肥胖症和相关病症和病症中：
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18.发明授权CIS-MORPHOLINONE AND OTHER COMPOUNDS AS MDM2 INHIBITORS FOR THE TREATMENT OF CANCER 有权CIS-吗啡酮和其他化合物作为MDM2抑制剂用于治疗癌症
公开(公告)号：EP2958902B1
公开(公告)日：2017-11-15
申请号：EP14708410.7
申请日：2014-02-18
Applicant: Amgen Inc.
Inventor： BARTBERGER, Michael, D. , BECK, Hilary, Plake , DEGRAFFENREID, Michael, R. , FOX, Brian, M. , GONZALEZ LOPEZ DE TURISO, Felix , JULIAN, Lisa, D. , KAYSER, Frank , MEDINA, Julio, C. , OLSON, Steven, H. , REW, Yosup , ROVETO, Philip, M. , SUN, Daqing , YAN, Xuelei
IPC: C07D265/32 , C07D413/04 , C07D413/06 , C07D279/12 , A61K31/5375 , A61K31/5377 , A61K31/54 , A61P35/00
CPC classification number: C07D265/32 , C07D279/12 , C07D413/04 , C07D413/06 , C07D487/04
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19.发明授权BENZAMIDE DERIVATIVES AND USES RELATED THERETO 有权在ZUSAMMENHANG STEHENDE ANWENDUNGEN BENZAMIDDERIVATE UND DAMIT
公开(公告)号：EP1904435B1
公开(公告)日：2013-01-02
申请号：EP06773288.3
申请日：2006-06-15
Applicant: Amgen Inc.
Inventor： POWERS, Jay P. , DEGRAFFENREID, Michael R. , HE, Xiao , JULIAN, Lisa , MCMINN, Dustin L. , SUN, Daqing , REW, Yosup , YAN, Xuelei
IPC: C07C235/42 , C07C237/22 , C07C255/24 , C07C255/31 , C07C255/44 , C07C255/46 , C07C255/60 , C07C317/36 , C07D211/16 , C07D211/18 , C07D211/22 , C07D211/34 , C07D211/38 , C07D211/52 , C07D211/60 , C07D211/64
CPC classification number: C07D277/28 , C07C235/42 , C07C235/54 , C07C237/42 , C07C255/29 , C07C255/31 , C07C255/44 , C07C255/46 , C07C255/60 , C07C317/36 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2602/42 , C07D211/16 , C07D211/18 , C07D211/22 , C07D211/34 , C07D211/38 , C07D211/52 , C07D211/60 , C07D211/64 , C07D213/40 , C07D213/61 , C07D213/74 , C07D213/81 , C07D213/84 , C07D213/89 , C07D233/64 , C07D295/192 , C07D307/22 , C07D309/14 , C07D333/20
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20.发明公开BENZAMIDE DERIVATIVES AS MODULATORS OF 11BETA-HSD1 FOR TREATING DIABETES AND OBESITY 有权BENZAMIDDERIVATE ALS MODULATOREN VON 11BETA-HSD1 ZUR BEHANDLUNG VON糖尿病在OBESITAS
公开(公告)号：EP2044004A2
公开(公告)日：2009-04-08
申请号：EP07795530.0
申请日：2007-05-31
Applicant: Amgen Inc.
Inventor： POWERS, Jay, P. , DEGRAFFENREID, Michael , JULIAN, Lisa , KAIZERMAN, Jacob , MCMINN, Dustin , REW, Yosup , SUN, Daqing , YAN, Xuelei , WANG, Zhulun
IPC: C07C235/54 , C07D333/24 , C07D213/56 , C07D333/38 , C07D213/57 , A61K31/166 , C07D239/26 , A61K31/381 , C07D261/08 , A61K31/4406 , C07D273/08 , A61K31/415 , C07D307/94 , A61K31/4409
CPC classification number: C07C235/42 , A61K31/166 , A61K31/381 , A61K31/42 , A61K31/426 , A61K31/44 , A61K31/4965 , A61K31/50 , A61K31/505 , C07C237/22 , C07C237/24 , C07C237/42 , C07C255/31 , C07C255/46 , C07C255/60 , C07C271/12 , C07C271/20 , C07C307/06 , C07C2601/02 , C07C2601/14 , C07C2603/94 , C07D213/30 , C07D213/53 , C07D237/08 , C07D239/26 , C07D241/12 , C07D261/08 , C07D277/22 , C07D277/24
Abstract: Benzamide derivatives of formula ( I ) are described and have therapeutic utility, particularly in the treatment of diabetes, obesity and related conditions and disorders, formula (I), wherein R1, R 2, R 3, R 4, R 5, R 6, R 7, R 8, and n are as defined herein.
Abstract translation: 描述了式I的苯甲酰胺衍生物，并且具有治疗用途，特别是在治疗糖尿病，肥胖症和相关病症和病症中：其中R1，R2，R3，R4，R5，R6，R7，R8和n如本文所定义。
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