PREPARATION OF 1-HYDROXYMETHYLOXIRANES WHICH ARE Z-SUBSTITUTED IN THE 2-POSITION

    公开(公告)号:CA2004489A1

    公开(公告)日:1990-07-18

    申请号:CA2004489

    申请日:1989-12-04

    Applicant: BASF AG

    Abstract: A process for the preparation of 1-hydroxymethyloxiranes which are Z-substituted in the 2-position, of the general formulae I and ent-I and (I) (ent-I) where A and B independently of one another are each C1C4-alkyl, phenyl, naphthyl or diphenyl or are each phenyl which is substituted by one to three radicals from the group consisting of halogen, C1-C4-alkyl, C1-C4-alkoxy, C1C4-haloalkyl, nitro and phenoxy, by reacting a ketone of the general formula II (II) where A and B have the abovementioned meanings and X is a group which can be eliminated under the reaction conditions, with trimethylsulfonium methylsulfate and a suitable base or with dimethyloxosulfonium methylide, and novel ketones of the general formula II' (II') where A' is phenyl or 4-fluorophenyl, B' is 2-fluoro-phenyl, 2-chlorophenyl, 2-bromophenyl or 2-trifluoro-methylphenyl and X' is hydroxyl or a leaving group, with the proviso that B' is not 2-chlorophenyl when A' is phenyl is described.

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