公开(公告)号：PL332704A1

公开(公告)日：1999-09-27

申请号：PL33270497

申请日：1997-10-09

Applicant: WARNER LAMBERT CO ,  BASF AG

Inventor： ALLEN HAMISH JOHN ,  BRADY KENNETH DALE ,  HARTER WILLIAM GLEN ,  LUNNEY ELIZABETH ANN ,  PLUMMER MARK STEPHEN ,  SAWYER TOMI ,  SHAHRIPOUR AURASH ,  WALKER NIGEL

IPC: A61K31/192 ,  A61K31/341 ,  A61P1/00 ,  A61P7/08 ,  A61P19/02 ,  A61P25/28 ,  A61P31/04 ,  C07C311/19 ,  C07C311/29 ,  C07C311/46 ,  C07C323/67 ,  C07D307/12 ,  C07C311/42 ,  A61K31/195 ,  A61K31/34

Abstract: PCT No. PCT/US97/18406 Sec. 371 Date Apr. 9, 1999 Sec. 102(e) Date Apr. 9, 1999 PCT Filed Oct. 9, 1997 PCT Pub. No. WO98/16504 PCT Pub. Date Apr. 23, 1998The present invention relates to compounds that are inhibitors of interleukin-1 beta converting enzyme that have the Formula I, II, or III. This invention also relates to a method of treatment of stroke, inflammatory diseases, septic shock reperfusion injury, Alzheimer's disease, and shigellosis, and to a pharmaceutically acceptable composition that contains a compound that is an inhibitor of interleukin-1 beta converting enzyme.

公开(公告)号：CA2309546A1

公开(公告)日：1999-07-22

申请号：CA2309546

申请日：1998-11-20

Applicant: BASF AG ,  WARNER LAMBERT CO

Inventor： SCHIELKE GERALD PAUL ,  SHAHRIPOUR AURASH

IPC: C07D239/47 ,  A61K31/505 ,  A61K38/00 ,  A61P25/00 ,  A61P25/28 ,  A61P29/00 ,  A61P31/04 ,  A61P43/00 ,  C07K5/02 ,  C07K5/06 ,  C07F9/6512 ,  A61K31/513

Abstract: This invention comprises the compound (1) and the pharmaceutically acceptable salts thereof. Compound (1) is an interleukin-1.beta. converting enzyme inhibitor and is useful for treating inflammatory diseases such as arthritis and inflammatory bowel disease, septic shock, reperfusion injury, shigellosis, and neuroinflammatory disorders such as stroke, multiple sclerosis, and Alzheimer's disease.

公开(公告)号：NO991678L

公开(公告)日：1999-04-12

申请号：NO991678

申请日：1999-04-09

Applicant: WARNER LAMBERT CO ,  BASF AG

Inventor： ALLEN HAMISH JOHN ,  BRADY KENNETH DALE ,  HARTER WILLIAM GLEN ,  LUNNEY ELIZABETH ANN ,  PLUMMER MARK STEPHEN ,  SAWYER TOMI ,  SHAHRIPOUR AURASH ,  WALKER NIGEL

IPC: A61K31/192 ,  A61K31/341 ,  A61P1/00 ,  A61P7/08 ,  A61P19/02 ,  A61P25/28 ,  A61P31/04 ,  C07C311/19 ,  C07C311/29 ,  C07C311/46 ,  C07C323/67 ,  C07D307/12 ,  A61K31/195

Abstract: PCT No. PCT/US97/18406 Sec. 371 Date Apr. 9, 1999 Sec. 102(e) Date Apr. 9, 1999 PCT Filed Oct. 9, 1997 PCT Pub. No. WO98/16504 PCT Pub. Date Apr. 23, 1998The present invention relates to compounds that are inhibitors of interleukin-1 beta converting enzyme that have the Formula I, II, or III. This invention also relates to a method of treatment of stroke, inflammatory diseases, septic shock reperfusion injury, Alzheimer's disease, and shigellosis, and to a pharmaceutically acceptable composition that contains a compound that is an inhibitor of interleukin-1 beta converting enzyme.