公开(公告)号：EP2358678B1

公开(公告)日：2015-01-14

申请号：EP09751875.7

申请日：2009-11-03

Applicant: BASF SE

Inventor： MENGES, Frederik ,  GEBHARDT, Joachim ,  RACK, Michael ,  KEIL, Michael ,  KLIMA, Rodney F. ,  CORTES, David. ,  LEICHT, Robert ,  ZECH, Helmut ,  SCHRÖDER, Jochen

IPC: C07D213/81 ,  C07D401/04 ,  C07D405/04

CPC classification number: C07D491/048 ,  C07D213/803 ,  C07D213/81 ,  C07D401/04 ,  C07D405/04

公开(公告)号：EP2358678A1

公开(公告)日：2011-08-24

申请号：EP09751875.7

申请日：2009-11-03

Applicant: BASF SE

Inventor： MENGES, Frederik ,  GEBHARDT, Joachim ,  RACK, Michael ,  KEIL, Michael ,  KLIMA, Rodney F. ,  CORTES, David. ,  LEICHT, Robert ,  ZECH, Helmut ,  SCHRÖDER, Jochen

IPC: C07D213/81 ,  C07D401/04 ,  C07D405/04

CPC classification number: C07D491/048 ,  C07D213/803 ,  C07D213/81 ,  C07D401/04 ,  C07D405/04

Abstract: A process for manufacturing 5-chloromethyl-2,3-pyridine dicarboxylic acid anhydrides (I) wherein Z is hydrogen or halogen; Z
1 is hydrogen, halogen, cyano or nitro; comprising the steps of (i) reacting a compound of formula (II), wherein the symbols have the meaning given in formula (I), with a chlorinating agent, optionally in the presence of a radical initiator in a solvent selected from halogenated hydrocarbons, and (ii) crystallizing the compound (I) formed in step (i) from a solvent selected from chlorobenzene, 1,2-dichlorobenzene, 1,3-dichlorobenzene, 1,4-dichlorobenzene, dichloroethane, trichloromethane, dichloromethane, toluene, xylenes, ethyl acetate, methyl tert.-butyl ether, and mixtures thereof. Compounds (I) are useful intermediates in the synthesis of herbicidal imidazolinones.

Abstract translation: 一种制备其中Z是氢或卤素的5-氯甲基-2,3-吡啶二羧酸酸酐（Ⅰ）的方法; Z 1是氢，卤素，氰基或硝基; 包括以下步骤：（i）使式（II）化合物（其中符号具有式（I）中给出的含义）与氯化剂任选在自由基引发剂存在下在选自卤代烃， （ii）使步骤（i）中形成的化合物（I）从选自氯苯，1,2-二氯苯，1,3-二氯苯，1,4-二氯苯，二氯乙烷，三氯甲烷，二氯甲烷，甲苯，二甲苯 ，乙酸乙酯，甲基叔丁基醚及其混合物。 化合物（I）是合成除草咪唑啉酮的有用中间体。