公开(公告)号：WO2012141771A1

公开(公告)日：2012-10-18

申请号：PCT/US2012/021338

申请日：2012-01-13

Applicant: BATTELLE MEMORIAL INSTITUTE ,  SHVARTSBURG, Alexandre A. ,  ANDERSON, Gordon A. ,  SMITH, Richard D.

Inventor： SHVARTSBURG, Alexandre A. ,  ANDERSON, Gordon A. ,  SMITH, Richard D.

IPC: H01J49/00 ,  H01J49/06

CPC classification number: H01J49/0018 ,  H01J49/066

Abstract: Electrodynamic ion funnels confine, guide, or focus ions in gases using the Dehmelt potential of oscillatory electric field. New funnel designs operating at or close to atmospheric gas pressure are described. Effective ion focusing at such pressures is enabled by fields of extreme amplitude and frequency, allowed in microscopic gaps that have much higher electrical breakdown thresholds in any gas than the macroscopic gaps of present funnels. The new microscopic-gap funnels are useful for interfacing atmospheric-pressure ionization sources to mass spectrometry (MS) and ion mobility separation (IMS) stages including differential IMS or FAIMS, as well as IMS and MS stages in various configurations. In particular, "wedge" funnels comprising two planar surfaces positioned at an angle and wedge funnel traps derived therefrom can compress ion beams in one dimension, producing narrow belt-shaped beams and laterally elongated cuboid packets. This beam profile reduces the ion density and thus space-charge effects, mitigating the adverse impact thereof on the resolving power, measurement accuracy, and dynamic range of MS and IMS analyzers, while a greater overlap with coplanar light or particle beams can benefit spectroscopic methods.

Abstract translation: 电动离子漏斗使用振荡电场的Dehmelt电位限制，引导或聚焦气体中的离子。 描述了处于或接近大气压力的新漏斗设计。 在这种压力下的有效离子聚焦是通过极大幅度和频率的场来实现的，微观间隙允许在任何气体中具有比当前漏斗的宏观间隙高得多的电击穿阈值。 新的微间隙漏斗可用于将大气压电离源与包括差分IMS或FAIMS的质谱（MS）和离子迁移率分离（IMS）阶段以及各种配置的IMS和MS阶段进行接口。 特别地，包括两个平坦的表面定位成角度的楔形漏斗和从其衍生的楔形漏斗捕获器可以在一个维度上压缩离子束，产生窄的带状波束和横向延伸的立方体分组。 这种光束轮廓降低了离子密度，从而降低了空间电荷效应，减轻了MS和IMS分析仪的分辨率，测量精度和动态范围的不利影响，而与共面光或粒子束的更大重叠可有利于光谱方法 。

公开(公告)号：EP3347913A1

公开(公告)日：2018-07-18

申请号：EP16724997.8

申请日：2016-05-02

Applicant: Battelle Memorial Institute

Inventor： IBRAHIM, Yehia M. ,  GARIMELLA, Sandilya V. B. ,  SMITH, Richard D.

IPC: H01J49/02 ,  H01J49/00 ,  G01N27/62

CPC classification number: H01J49/26 ,  G01N27/622 ,  H01J49/0013 ,  H01J49/022 ,  H01J49/40

Abstract: Methods and devices for ion separations or manipulations in gas phase are disclosed. The device includes a non-planar surface having a first, second and third region. An inner arrays of electrodes is positioned on the first region. A first set of electrodes of the inner array of electrodes is configured to receive RF voltages and generate a first potential upon the receipt of the RF voltage. A first and second outer arrays of electrodes are coupled to the second and third region, respectively. The first and second outer arrays are configured to receive a first DC voltage and generate a second potential upon the receipt of the first DC voltages. The first and second generated potential manipulate movement of ions.

公开(公告)号：EP3729489A1

公开(公告)日：2020-10-28

申请号：EP18834097.0

申请日：2018-12-13

Applicant: Battelle Memorial Institute

Inventor： IBRAHIM, Yehia M. ,  SMITH, Richard D.

IPC: H01J49/06

公开(公告)号：EP2984675A1

公开(公告)日：2016-02-17

申请号：EP14782685.3

申请日：2014-01-13

Applicant: Battelle Memorial Institute

Inventor： ANDERSON, Gordon A. ,  SMITH, Richard D. ,  IBRAHIM, Yehia M. ,  BAKER, Erin M.

IPC: H01J49/00 ,  H01J49/04 ,  H01J49/40

CPC classification number: H01J49/062 ,  G01N27/622 ,  H01J49/06

Abstract: An ion manipulation method and device is disclosed. The device includes a pair of substantially parallel surfaces. An array of inner electrodes is contained within, and extends substantially along the length of, each parallel surface. The device includes a first outer array of electrodes and a second outer array of electrodes. Each outer array of electrodes is positioned on either side of the inner electrodes, and is contained within and extends substantially along the length of each parallel surface. A DC voltage is applied to the first and second outer array of electrodes. A RF voltage, with a superimposed electric field, is applied to the inner electrodes by applying the DC voltages to each electrode. Ions either move between the parallel surfaces within an ion confinement area or along paths in the direction of the electric field, or can be trapped in the ion confinement area.

公开(公告)号：EP3155634A1

公开(公告)日：2017-04-19

申请号：EP15731192.9

申请日：2015-06-10

Applicant: Battelle Memorial Institute

Inventor： IBRAHIM, Yehia M. ,  CHEN, Tsung-Chi ,  HARRER, Marques B. ,  TANG, Keqi ,  SMITH, Richard D.

IPC: H01J49/06 ,  G01N27/62

CPC classification number: H01J49/066

Abstract: An ion funnel device is disclosed. A first pair of electrodes is positioned in a first direction. A second pair of electrodes is positioned in a second direction. The device includes an RF voltage source and a DC voltage source. A RF voltage with a superimposed DC voltage gradient is applied to the first pair of electrodes, and a DC voltage gradient is applied to the second pair of electrodes.

Abstract translation: 公开了一种离子漏斗装置。 第一对电极位于第一方向。 第二对电极位于第二方向。 该器件包括一个RF电压源和一个直流电压源。 将具有叠加的直流电压梯度的RF电压施加到第一对电极，并且将直流电压梯度施加到第二对电极。

公开(公告)号：EP2697818A1

公开(公告)日：2014-02-19

申请号：EP12702352.1

申请日：2012-01-13

Applicant: Battelle Memorial Institute

Inventor： SHVARTSBURG, Alexandre A. ,  ANDERSON, Gordon A. ,  SMITH, Richard D.

IPC: H01J49/00 ,  H01J49/06

CPC classification number: H01J49/0018 ,  H01J49/066

Abstract: Electrodynamic ion funnels confine, guide, or focus ions in gases using the Dehmelt potential of oscillatory electric field. New funnel designs operating at or close to atmospheric gas pressure are described. Effective ion focusing at such pressures is enabled by fields of extreme amplitude and frequency, allowed in microscopic gaps that have much higher electrical breakdown thresholds in any gas than the macroscopic gaps of present funnels. The new microscopic-gap funnels are useful for interfacing atmospheric-pressure ionization sources to mass spectrometry (MS) and ion mobility separation (IMS) stages including differential IMS or FAIMS, as well as IMS and MS stages in various configurations. In particular, "wedge" funnels comprising two planar surfaces positioned at an angle and wedge funnel traps derived therefrom can compress ion beams in one dimension, producing narrow belt-shaped beams and laterally elongated cuboid packets. This beam profile reduces the ion density and thus space-charge effects, mitigating the adverse impact thereof on the resolving power, measurement accuracy, and dynamic range of MS and IMS analyzers, while a greater overlap with coplanar light or particle beams can benefit spectroscopic methods.

Abstract translation: 电动离子漏斗利用振荡电场的Dehmelt电势来限制，引导或集中离子在气体中。 描述了以大气压力或接近大气压力运行的新漏斗设计。 在这样的压力下有效的离子聚焦通过极大幅度和频率的场来实现，允许在任何气体中具有比当前漏斗的宏观间隙高得多的电击穿阈值的微观间隙。 新的微观漏斗可用于将大气压电离源连接到质谱（MS）和离子迁移分离（IMS）阶段，包括差异IMS或FAIMS，以及各种配置中的IMS和MS阶段。 具体地说，包括以一定角度定位的两个平面表面和由其衍生的楔形漏斗陷阱的“楔形”漏斗可以在一个维度上压缩离子束，从而产生窄的带形梁和横向伸长的长方体包。 该光束轮廓降低了离子密度和空间电荷效应，减轻了其对MS和IMS分析仪的分辨能力，测量精度和动态范围的不利影响，而与共面光或粒子束更大的重叠可以有利于光谱方法 。