公开(公告)号：ES2509919T3

公开(公告)日：2014-10-20

申请号：ES10719211

申请日：2010-05-13

Applicant: BAXTER INT ,  BAXTER HEALTHCARE SA

Inventor： RABINOW BARRETT ,  BAIRSTOW SHAWN F ,  CHAUBAL MAHESH V ,  LEE SARAH ,  WERLING JANE

IPC: A61K9/14 ,  A61K31/337 ,  A61K31/365 ,  A61K31/415 ,  A61K31/427 ,  A61K31/444 ,  A61K31/496 ,  A61K31/513 ,  A61K31/538 ,  A61K31/551 ,  A61K31/708 ,  A61K47/34 ,  A61P35/00

Abstract: Partícula de superficie modificada que comprende un núcleo de partícula y un revestimiento asociado al núcleo de partícula, comprendiendo el núcleo de partícula un principio activo seleccionado de entre el grupo consistente en moléculas pequeñas, péptidos y proteínas, comprendiendo el revestimiento un agente tensioactivo de fórmula I o una sal del mismo, y presentando la partícula de superficie modificada un tamaño medio entre aproximadamente 1 nm y aproximadamente 2.000 nm: donde n y m son 1; R1, R2 y R3 son metilo; y R4 y R5 se seleccionan independientemente entre el grupo consistente en cis-9-octadecenoílo y cis-9- octadecenilo.

公开(公告)号：AU2010249008B2

公开(公告)日：2014-06-05

申请号：AU2010249008

申请日：2010-05-13

Applicant: BAXTER HEALTHCARE SA ,  BAXTER INT

Inventor： RABINOW BARRETT ,  BAIRSTOW SHAWN F ,  CHAUBAL MAHESH V ,  LEE SARAH ,  WERLING JANE

IPC: A61K9/14 ,  A61K31/337 ,  A61K47/34 ,  A61P35/00

Abstract: The present disclosure is directed to surface-modified particles and to methods of making and using the same. The surface-modified particles comprise a particle core and a coating associated with the particle core, wherein the particle core comprises an active agent, the coating comprises a surfactant having formula (I) or a salt thereof, and the surface-modified particle has an average size from about 1 nm to about 2,000 nm:

公开(公告)号：CA2761801A1

公开(公告)日：2010-11-18

申请号：CA2761801

申请日：2010-05-13

Applicant: BAXTER INT ,  BAXTER HEALTHCARE SA

Inventor： RABINOW BARRETT ,  BAIRSTOW SHAWN F ,  CHAUBAL MAHESH V ,  LEE SARAH ,  WERLING JANE

IPC: A61K9/14 ,  A61K31/337 ,  A61K47/34 ,  A61P35/00

Abstract: The present disclosure is directed to surface-modified particles and to methods of making and using the same. The surface-modified particles comprise a particle core and a coating associated with the particle core, wherein the particle core comprises an active agent, the coating comprises a surfactant having formula (I) or a salt thereof, and the surface-modified particle has an average size from about 1 nm to about 2,000 nm:

公开(公告)号：AU2005209243A1

公开(公告)日：2005-08-11

申请号：AU2005209243

申请日：2005-01-21

Applicant: BAXTER HEALTHCARE SA ,  BAXTER INT

Inventor： CHAUBAL MAHESH V ,  RABINOW BARRETT E ,  WERLING JANE ,  KIPP JAMES E

IPC: A61K9/10 ,  A61K9/14 ,  A61K9/51 ,  A61K31/00 ,  A61K31/551 ,  A61K31/7072 ,  A61K31/7076

Abstract: The present invention provides compositions comprising dispersions of anti-retroviral agents and methods of manufacture. The nanosuspensions are made by the process of microprecipitation and energy addition. Preferably, the nanosuspensions are made by the tandem process of microprecipitation-homogenization.