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    BLOOD COAGULATION PROTEIN CONJUGATES
    12.
    发明申请
    BLOOD COAGULATION PROTEIN CONJUGATES 审中-公开
    血液凝固蛋白缀合物

    公开(公告)号：WO2011017055A3

    公开(公告)日：2011-04-07

    申请号：PCT/US2010043242

    申请日：2010-07-26

    Applicant: BAXTER INT ,  BAXTER HEALTHCARE SA ,  SIEKMANN JUERGEN ,  HAIDER STEFAN ,  ROTTENSTEINER HANSPETER ,  TURECEK PETER

    Inventor： SIEKMANN JUERGEN ,  HAIDER STEFAN ,  ROTTENSTEINER HANSPETER ,  TURECEK PETER

    IPC: A61K47/48

    CPC classification number: A61K47/4823 ,  A61K38/37 ,  A61K38/4846 ,  A61K47/60 ,  A61K47/61 ,  C08B37/0006 ,  C12N9/6437 ,  C12N9/644 ,  C12N9/96 ,  C12Y304/21021 ,  C12Y304/21022

    Abstract: The invention relates to materials and methods of conjugating a water soluble polymer to an oxidized carbohydrate moiety of a blood coagulation protein comprising contacting the oxidized carbohydrate moiety with an activated water soluble polymer under conditions that allow conjugation. More specifically, the present invention relates to the aforementioned materials and methods wherein the water soluble polymer contains an active aminooxy group and wherein an oxime linkage is formed between the oxidized carbohydrate moiety and the active aminooxy group on the water soluble polymer. In one embodiment of the invention the conjugation is carried out in the presence of the nucleophilic catalyst aniline. In addition the generated oxime linkage can be stabilized by reduction with NaCNBH3 to form an alkoxyamine linkage.

    Abstract translation: 本发明涉及使水溶性聚合物与血液凝固蛋白的氧化碳水化合物部分缀合的材料和方法，包括使氧化碳水化合物部分与活化的水溶性聚合物在允许缀合的条件下接触。 更具体地说，本发明涉及上述材料和方法，其中水溶性聚合物含有活性氨氧基，并且其中在水溶性聚合物上的氧化碳水化合物部分和活性氨氧基之间形成肟键。 在本发明的一个实施方案中，缀合在亲核催化剂苯胺存在下进行。 另外，生成的肟键可以通过用NaCNBH 3还原形成烷氧基胺键来稳定。

    POLYMER-VON WILLEBRAND FACTOR-CONJUGATES
    15.
    发明申请
    POLYMER-VON WILLEBRAND FACTOR-CONJUGATES 审中-公开
    POLYMER-VON WILLEBRAND因子联合

    公开(公告)号：WO2006071801A3

    公开(公告)日：2007-08-16

    申请号：PCT/US2005046879

    申请日：2005-12-23

    Applicant: BAXTER INT ,  BAXTER HEALTHCARE SA ,  SCHEIFLINGER FRIEDRICH ,  TURECEK PETER ,  SIEKMANN JUERGEN

    Inventor： SCHEIFLINGER FRIEDRICH ,  TURECEK PETER ,  SIEKMANN JUERGEN

    IPC: A61K47/48

    CPC classification number: C07K14/755 ,  A61K47/60 ,  C07K14/775

    Abstract: The present invention relates to a proteinaceous construc (also designated as polymer-VWF-conjugate) comprising plasmatic and/or recombinant von Willebrand factor (VWF), said VWF being bound to at least one physiologically acceptable polymer molecule, as well as to a complex said proteinaceous construc and at least one factor VIII (FVIII) protein. The physiologically acceptable polymer molecule can be, for instance, polyethylene glycol (PEG) or polysialic acid (PSA). Further the present invention relates to methods for prolonging the in vivo-half-life of VWF or FVIII in the blood of a mammal having a bleeding disorder associated with functional defects of or deficiencies of at least one of FVIII or VWF.

    Abstract translation: 本发明涉及包含血浆和/或重组血管性血友病因子（VWF）的蛋白质结构（也称为聚合物-WWF-缀合物），所述VWF与至少一种生理上可接受的聚合物分子结合，以及复合物 所述蛋白质结构和至少一种因子VIII（FVIII）蛋白。 生理上可接受的聚合物分子可以是例如聚乙二醇（PEG）或聚唾液酸（PSA）。 此外，本发明涉及用于延长具有与FVIII或VWF中的至少一种的功能缺陷或缺陷相关的出血性疾病的哺乳动物的血液中VWF或FVIII的体内半衰期的方法。

    A KIT FOR MEASURING THE THROMBIN GENERATION IN A SAMPLE OF A PATIENT'S BLOOD OR PLASMA
    18.
    发明申请
    A KIT FOR MEASURING THE THROMBIN GENERATION IN A SAMPLE OF A PATIENT'S BLOOD OR PLASMA 审中-公开
    用于测量患者血液或血浆中血凝素生成的试剂盒

    公开(公告)号：WO2005095638A2

    公开(公告)日：2005-10-13

    申请号：PCT/EP2005003328

    申请日：2005-03-30

    Applicant: BAXTER INT ,  BAXTER HEALTHCARE SA ,  VARADI KATALIN ,  TURECEK PETER ,  KEIL BRIGITTE ,  PEYRER-HEIMSTAETT SYLVIA ,  SCHWARZ HANS-PETER

    Inventor： VARADI KATALIN ,  TURECEK PETER ,  KEIL BRIGITTE ,  PEYRER-HEIMSTAETT SYLVIA ,  SCHWARZ HANS-PETER

    IPC: C12Q1/56 ,  G01N33/86

    CPC classification number: A61K31/66 ,  C12Q1/56 ,  G01N33/86 ,  G01N2333/745

    Abstract: The invention provides a kit for measuring the thrombin generation in a sample of a patient's blood or plasma, or in a sample of clotting factors. The kit contains lyophilized tissue factor/phospholipid-complex and a lyophilized mixture containing a thrombin-substrate and CaCl2. The invention also provides processes for preparing the reagents for the kit. The kit can be used in a method for measuring the thrombin generation in a sample, wherein it is possible to detect changes in thrombin generation kinetics, for example after administration of inhibitor bypassing agents to a patient who has developed inhibitors to an exogenous clotting factor such as Factor VIII.

    Abstract translation: 本发明提供了一种用于测量患者血液或血浆样品或凝血因子样品中的凝血酶产生的试剂盒。 该试剂盒含有冻干组织因子/磷脂复合物和含有凝血酶底物和CaCl 2的冻干混合物。 本发明还提供了用于制备试剂盒的试剂的方法。 该试剂盒可以用于测量样品中凝血酶产生的方法，其中可以检测凝血酶产生动力学的变化，例如在将抑制剂旁路剂施用于已经开发出外源凝血因子的抑制剂的患者之后 作为因子VIII。

    METHOD OF DETECTING PRP PROTEIN AND KITS THEREFOR
    19.
    发明申请
    METHOD OF DETECTING PRP PROTEIN AND KITS THEREFOR 审中-公开
    检测PRP蛋白及其作用的方法

    公开(公告)号：WO02057793A3

    公开(公告)日：2003-03-06

    申请号：PCT/US0201297

    申请日：2002-01-18

    Applicant: BAXTER INT ,  BAXTER HEALTHCARE SA

    Inventor： VOELKEL DIRK ,  ZIMMERMANN KLAUS ,  TURECEK PETER ,  SCHWARZ HANS-PETER

    IPC: G01N33/58 ,  G01N33/68 ,  G01N33/543

    CPC classification number: G01N33/582 ,  G01N33/6896 ,  G01N2800/28

    Abstract: The invention relates to a method for the detection of neurological disorders in patient comprising (a) measuring the concentration of PrP protein in a biological fluid sample of said patient; and (b) determining whether said concentration of said PrP protein is above or below a predetermined threshold value, whereby the concentration above said predetermined threshold value identifies a patient with a neurological disorder, a method for the detection and quantification of PrP protein and pathogenic PrP protein in a sample, and a kit comprising a set of reagents to determine the concentration of PrP protein and pathogenic PrP protein in a sample.

    Abstract translation: 本发明涉及一种用于检测患者神经系统疾病的方法，包括（a）测量所述患者的生物流体样品中PrP蛋白的浓度; 和（b）确定所述PrP蛋白的所述浓度是否高于或低于预定阈值，由此超过所述预定阈值的浓度识别具有神经障碍的患者，用于检测和定量PrP蛋白和致病性PrP的方法 样品中的蛋白质和包含一组试剂以测定样品中PrP蛋白和致病性PrP蛋白的浓度的试剂盒。

    GLYCOPOLYSIALYLATION OF NON-BLOOD COAGULATION PROTEINS
    20.
    发明申请
    GLYCOPOLYSIALYLATION OF NON-BLOOD COAGULATION PROTEINS 审中-公开
    非血液凝聚蛋白的糖苷化

    公开(公告)号：WO2011012850A2

    公开(公告)日：2011-02-03

    申请号：PCT/GB2010001422

    申请日：2010-07-26

    Applicant: LIPOXEN TECHNOLOGIES LTD ,  JAIN SANJAY ,  GREGORIADIS GREGORY ,  DWIVEDI ARCHANA ,  NATH SRIJIT ,  SIEKMANN JUERGEN ,  HAIDER STEFAN ,  ROTTENSTEINER HANSPETER ,  TURECEK PETER ,  BAXTER INT ,  BAXTER HEALTHCARE SA

    Inventor： JAIN SANJAY ,  GREGORIADIS GREGORY ,  DWIVEDI ARCHANA ,  NATH SRIJIT ,  SIEKMANN JUERGEN ,  HAIDER STEFAN ,  ROTTENSTEINER HANSPETER ,  TURECEK PETER

    IPC: A61K47/48

    CPC classification number: A61K47/6455 ,  A61K47/4823 ,  A61K47/60 ,  A61K47/61 ,  A61K47/65

    Abstract: A water soluble polymer, in particular polysialic acid (PSA) or a modified PSA (mPSA), is conjugated to an oxidized carbohydrate moiety of a glycoprotein other than a blood coagulation protein or to a ganglioside or drug delivery system by contacting the oxidized carbohydrate moiety with the water soluble polymer, wherein said water soluble polymer contains an aminooxy group and an oxime linkage is formed between the oxidized carbohydrate moiety and the aminooxy group on the water soluble polymer or wherein said water soluble polymer contains a hydrazide group and a hydrazone linkage is formed between the oxidized carbohydrate moiety and the hydrazide group on the water soluble polymer. Conjugates of aminooxy- or hydrazide-water soluble polymer, such as PSA and mPSA, are thus obtained in which the PSA or mPSA is attached via a carbohydrate moiety.

    Abstract translation: 将水溶性聚合物，特别是聚唾液酸（PSA）或修饰的PSA（mPSA）与不同于凝血蛋白的糖蛋白的氧化碳水化合物部分或通过使氧化的碳水化合物部分接触而与神经节苷脂或药物递送系统结合 其中所述水溶性聚合物含有氨基氧基，并且在水溶性聚合物上的氧化碳水化合物部分和氨基氧基之间形成肟键，或者其中所述水溶性聚合物含有酰肼基，腙键是 形成在水溶性聚合物上的氧化碳水化合物部分和酰肼基团之间。 因此得到氨基氧基或酰肼 - 水溶性聚合物如PSA和mPSA的结合物，其中PSA或mPSA通过碳水化合物部分连接。

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