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    BEAD READER
    13.
    发明公开
    BEAD READER 有权
    光学检测单元与珠测试系统

    公开(公告)号：EP2507620A2

    公开(公告)日：2012-10-10

    申请号：EP10795779.7

    申请日：2010-11-29

    Applicant: Bio-Rad Laboratories, Inc.

    Inventor： RAN, Boaz ,  SLUSZNY, Chanan ,  NIMRI, Shay

    IPC: G01N21/64

    CPC classification number: G01N21/76 ,  G01N15/0612 ,  G01N15/1463 ,  G01N21/6428 ,  G01N21/6452 ,  G01N21/6456 ,  G01N21/78 ,  G01N35/0098 ,  G01N2015/1486 ,  G01N2021/6419 ,  G01N2021/6421 ,  G01N2035/1046 ,  Y10T436/25

    Abstract: A method of determining a normalized quantity of an analyte adhering to beads ( 310 ) in a detection area ( 312 ) of a bead-based assaying system ( 300 ), the method comprising: a) causing a complex of the analyte to fluorescently or chemically emit a first light ( 2 ), or to release a dye; b) measuring an integrated intensity of the first light emitted from the beads in the detection area, or a concentration of the dye released from the beads in the detection area, or both; c) causing light ( 1 ) to interact with the beads in the detection area, the interaction not depending on whether or how much analyte is adhering to the beads; d) measuring a second light ( 1 ) resulting from the interaction with the beads which does not depend on the analyte; and e) determining the normalized quantity of analyte from the integrated intensity of the first light or concentration of the dye or both, and from the measured second light.

    NON-DESTRUCTIVE READ OPERATIONS WITH DYNAMICALLY GROWING IMAGES
    15.
    发明公开
    NON-DESTRUCTIVE READ OPERATIONS WITH DYNAMICALLY GROWING IMAGES 审中-公开
    动态生长图像的非破坏性阅读操作

    公开(公告)号：EP2989443A1

    公开(公告)日：2016-03-02

    申请号：EP14869916.8

    申请日：2014-12-09

    Applicant: Bio-rad Laboratories, Inc.

    Inventor： SWIHART, Steve ,  THRUSH, Evan ,  RAN, Boaz

    IPC: G01N21/27

    CPC classification number: H04N5/2355 ,  G01N21/272 ,  G01N21/6408 ,  G01N21/6456 ,  G01N21/76 ,  H04N5/2173 ,  H04N5/2353 ,  H04N5/35545 ,  H04N5/361 ,  H04N5/365

    Abstract: Methods and digital imaging devices disclosed herein are adapted to capture images of a specimen in a chemical reaction using a series of short exposures of light emissions from the specimen over a period of time. The series of short exposures is captured using an array of pixels of an image sensor in the digital imaging device that are configured for performing continuous non-destructive read operations to read out a set of non-destructive read images of the specimen from the pixel array. In one embodiment, images are captured by delaying the read out until at or near the end of the chemical reaction to reduce read noise in the images. The signals read out from the image sensor can be continuously monitored and the capturing of images can be discontinued either automatically or based on a command from a user. The captured images can then be displayed in a graphical display.

    Abstract translation: 本文公开的方法和数字成像装置适于在一段时间内使用来自样本的一系列短时间曝光来捕获化学反应中的样本的图像。 该系列短暴露是使用在数字成像设备的图像传感器，其被配置用于执行连续的非破坏性读操作，以从所述像素阵列读出的一组试样的非破坏性读出的图像中的像素的阵列捕获 。 在一个实施例中，通过延迟读出直到在化学反应结束或接近结束时捕获图像以减少图像中的读取噪声。 从图像传感器读取的信号可以连续监测，并且图像的捕获可以自动地或基于来自用户的命令而中断。 捕获的图像可以显示在图形显示中。

    DIGITAL IMAGING WITH MASKED PIXELS
    19.
    发明公开
    DIGITAL IMAGING WITH MASKED PIXELS 有权
    用遮罩像素进行数字成像

    公开(公告)号：EP2987181A1

    公开(公告)日：2016-02-24

    申请号：EP14869552.1

    申请日：2014-12-09

    Applicant: Bio-Rad Laboratories, Inc.

    Inventor： RAN, Boaz ,  SWIHART, Steve ,  THRUSH, Evan ,  BARAK, Itay

    IPC: H01L23/552

    CPC classification number: H04N5/361 ,  H01L2924/0002 ,  H04N5/365 ,  H01L2924/00

    Abstract: One embodiment of the invention is directed to an imaging device comprising an image sensor comprising an array of pixels, and a mask coupled with the image sensor, the mask configured to darken at least one pixel in the array of pixels.

    Abstract translation: 本发明的一个实施例针对包括图像传感器的成像装置，该图像传感器包括像素阵列以及与该图像传感器耦合的掩模，该掩模被配置为使像素阵列中的至少一个像素变暗。

    SURFACE PLASMON RESONANCE SENSOR
    20.
    发明授权
    SURFACE PLASMON RESONANCE SENSOR 有权
    表面等离子体共振传感器

    公开(公告)号：EP1581800B1

    公开(公告)日：2009-06-17

    申请号：EP02808314.5

    申请日：2002-12-25

    Applicant: Bio-Rad Laboratories, Inc.

    Inventor： RAN, Boaz ,  NOTCOVICH, Ariel, G. ,  LIPSON, Ariel ,  NIMRI, Shay ,  LIPSON, Stephen, G. ,  LIPSON, Doron

    IPC: G01N21/55 ,  G01J3/30

    CPC classification number: G01N21/55 ,  G01N21/553 ,  G01N2021/058

    Abstract: An SPR sensor comprising: a thin conducting layer comprising at least one conductive element formed on a surface of a transparent substrate; an illumination system controllable to illuminate an interface between the conducting layer and the substrate; a photosensitive surface that generates signals responsive to light from the light source that is reflected from a region of the interface; a flow cell formed with at least one flow channel having a lumen defined by a wall at least a portion of which is formed from an elastic material and a portion of which is formed by a region of the conducting layer; and at least one hollow needle having an exit orifice communicating with the needle's lumen and wherein fluid flow is enabled between the flow channel and the needle's lumen by puncturing the elastic material with the at least one needle so that the exit orifice communicates with the flow channel lumen.

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