公开(公告)号：CL2015000015A1

公开(公告)日：2015-03-06

申请号：CL2015000015

申请日：2015-01-05

Applicant: BASF SE ,  WINTERSHALL HOLDING GMBH

Inventor： BROCKMANN BEATA ,  HEROLD ANDREA ,  ZELDER OSKAR ,  HAEFNER STEFAN ,  FLECK CHRISTIAN ,  SCHRÖDER HARTWIG ,  GRANSTRÖM MARI ,  SCHMIDT JULIA KRISTIANE

IPC: C12N9/10 ,  C12P19/04

公开(公告)号：BRPI0618080A2

公开(公告)日：2012-02-22

申请号：BRPI0618080

申请日：2006-10-23

Applicant: BASF SE

Inventor： ZELDER OSKAR ,  HEROLD ANDREA ,  KLOPPROGGE CORINNA ,  SCHROEDER HARTWIG ,  HAEFNER STEFAN ,  HEINZLE ELMAR ,  WITTMANN CHRISTOPH ,  KROEMER JENS ,  PERO JANICE G ,  YOCUM R ROGERS ,  PATTERSON THOMAS A ,  WILLIAMS MARK ,  HERMANN THERON

IPC: A23K1/00 ,  C12N15/52 ,  C12P13/12

Abstract: The present invention relates to microorganisms and processes for the efficient preparation of L-amino acids such as L-methionine. In particular, the present invention relates to microorganisms and processes in which the formation and/or accumulation of homolanthionine in the methionine pathway is reduced and/or prevented.

公开(公告)号：AU2022342359A1

公开(公告)日：2024-03-21

申请号：AU2022342359

申请日：2022-09-09

Applicant: BASF SE

Inventor： MAY TOBIAS ,  HEROLD ANDREA ,  HEINRICH DANIEL CHRISTOPH ,  HEUSCHKEL INGEBORG ,  SENDROWSKI HEIKO

IPC: C07K14/195 ,  A01N63/00 ,  C12P19/00

Abstract: The invention is concerned with genes involved in Firmicutes exopolysaccharide production. The invention provides mutations to those genes and corresponding mutated proteins to increase or stabilise exopolysaccharide production or prevent exopolysaccharide autodegradation, in particular over the course of a fermentation. The invention also provides suitable fermentation methods and uses of the mutated genes and proteins, of the microorganisms and the exopolysaccharides.

公开(公告)号：AR127735A1

公开(公告)日：2024-02-21

申请号：ARP220103202

申请日：2022-11-22

Applicant: BASF SE

Inventor： MAY TOBIAS ,  ZIMMERMANN JUDITH ,  TOKOVENKO BOGDAN ,  HEINRICH DANIEL CHRISTOPH ,  STIERL REINHARD ,  HEROLD ANDREA

IPC: C12N1/20 ,  A01N63/25 ,  A01P3/00

Abstract: Cepas de especies de Paenibacillus que producen bajas cantidades de compuestos que requieren L-2,4-diaminobutanoato como precursor y exopolisacáridos que comprenden bajas cantidades de compuestos que requieren L-2,4-diaminobutanoato como precursor, así como mezclas, composiciones y métodos que comprenden estas cepas de especies de Paenibacillus y/o exopolisacáridos.

公开(公告)号：CA3230902A1

公开(公告)日：2023-03-16

申请号：CA3230902

申请日：2022-09-09

Applicant: BASF SE

Inventor： MAY TOBIAS ,  HEROLD ANDREA ,  HEINRICH DANIEL CHRISTOPH ,  HEUSCHKEL INGEBORG ,  SENDROWSKI HEIKO

Abstract: The invention is concerned with genes involved in Firmicutes exopolysaccharide production. The invention provides mutations to those genes and corresponding mutated proteins to increase or stabilise exopolysaccharide production or prevent exopolysaccharide autodegradation, in particular over the course of a fermentation. The invention also provides suitable fermentation methods and uses of the mutated genes and proteins, of the microorganisms and the exopolysaccharides.

公开(公告)号：HUE025440T2

公开(公告)日：2016-04-28

申请号：HUE07821516

申请日：2007-10-18

Applicant: BASF SE

Inventor： HEROLD ANDREA ,  KLOPPROGGE CORINNA ,  SCHROEDER HARTWIG ,  ZELDER OSKAR ,  JEONG WEOL KYU

IPC: C12N15/77

公开(公告)号：CA2875603A1

公开(公告)日：2014-01-09

申请号：CA2875603

申请日：2013-07-03

Applicant: WINTERSHALL HOLDING GMBH ,  BASF SE

Inventor： BROCKMANN BEATA ,  HEROLD ANDREA ,  ZELDER OSKAR ,  HAEFNER STEFAN ,  FLECK CHRISTIAN ,  SCHRODER HARTWIG ,  GRANSTROM MARI ,  SCHMIDT JULIA KRISTIANE

IPC: C12N9/10 ,  C12P19/04

Abstract: The present invention relates to genetically modified microorganisms capable of producing beta-glucans, characterized in that said genetically modified microorganism overexpresses (i) a polynucleotide encoding a polypeptide having 1,3-ß-D-glucan synthase-activity, and/or (ii) a polypeptide having 1,3-ß-glucan synthase-activity, compared to a corresponding non-modified control microorganism of the same strain. The present invention also relates to the use of a polynucleotide encoding a polypeptide having 1,3-ß-D-glucan synthase-activity or the use of such a polypeptide for producing ß-glucans. Furthermore, the present invention relates to methods for producing ß-glucans comprising the introduction of a promoter upstream of a polynucleotide encoding a polypeptide having 1,3-ß-D-glucan synthase-activity thereby increasing the expression of said polynucleotide, or a polynucleotide encoding a polypeptide having 1,3-ß-D-glucan synthase-activity into a microorganism being able to synthesize ß-glucans.

公开(公告)号：ES2380000T3

公开(公告)日：2012-05-07

申请号：ES07123772

申请日：2005-12-21

Applicant: BASF SE

Inventor： HAEFNER STEFAN ,  SCHROEDER HARTWIG ,  ZELDER OSKAR ,  KLOPPROGGE CORINNA ,  HEROLD ANDREA

IPC: C12N15/77 ,  C07K14/34

Abstract: Bacteria corineforme genéticamente modificada, transformada con al menos un vector que contiene al menos un casete de expresión, en cuyo caso el casete de expresión comprende en dirección 5' -3' un módulo de secuencia de la siguiente fórmula general II: 5' -P1-(-Ax-Px-)n-Ay-Py-G-3' (II) Donde n representa un valor de número entero de 0 a 10, Ax y Ay son iguales o diferentes y representan un enlace químico o una secuencia de ácido nucleico enlazante; P1, Px y Py codifican secuencias de promotores iguales o diferentes derivadas de bacterias corineformes iguales o diferentes, que comprenden al menos un segmento que enlaza polimerasa de ARN; y al menos Py comprende un segmento de secuencia terminal 3' que facilita el enlace ribosómico, G representa al menos una secuencia de ácido nucleico codificante que está enlazada funcionalmente con la secuencia regulatoria ubicada corriente arriba de 5'.

公开(公告)号：BRPI0709628A2

公开(公告)日：2011-07-19

申请号：BRPI0709628

申请日：2007-03-23

Applicant: BASF SE

Inventor： ZELDER OSKAR ,  JEONG WEOL KYU ,  KLOPPROGGE CORINNA ,  HEROLD ANDREA ,  SCHROEDER HARTWIG

IPC: C12P13/00 ,  C12P13/02 ,  C12R1/15

Abstract: Process for the production of cadaverine by constructing a recombinant microorganism which has a deregulated lysine decarboxylase gene and at least one deregulated gene selected from the group (i) which consists of aspartokinase, aspartatesemialdehyde dehydrogenase, dihydrodipicolinate synthase, dihydrodipicolinate reductase, tetrahydrodipicolinate succinylase, succinyl-amino-ketopimelate transaminase, succinyl-diamino-pimelate desuccinylase, diaminopimelate epimerase, diaminopimelate dehydrogenase, arginyl-tRNA synthetase, diaminopimelate decarboxylase, pyruvate carboxylase, phosphoenolpyruvate carboxylase, glucose-6-phosphate dehydrogenase, transketolase, transaldolase, 6-phosphogluconolactonase, fructose 1,6-biphosphatase, homoserine dehydrogenase, phophoenolpyruvate carboxykinase, succinyl-CoA synthetase, methylmalonyl-CoA mutase, provided that if aspartokinase is deregulated as gene (i) at least a second gene (i) other than aspartokinase has to be deregulated, and cultivating said microorganism.

公开(公告)号：CA2712427A1

公开(公告)日：2009-08-13

申请号：CA2712427

申请日：2009-02-04

Applicant: BASF SE

Inventor： ZELDER OSKAR ,  JEONG WEOL KYU ,  KLOPPROGGE CORINNA ,  HEROLD ANDREA ,  SCHROEDER HARTWIG

IPC: C12P17/12 ,  C12N9/02

Abstract: The present invention relates to a novel method for the fermentative production of dipicolinate by cultivating a recombinant microorganism expressing an enzyme having dipicolinate synthetase activity. The present invention also relates to corresponding recombinant hosts, recombinant vectors, expression cassettes and nucleic acids suitable for preparing such hosts as well as a method of preparing polyester or polyamide copolymers making use of dipicolinate as obtained by fermentative production.