公开(公告)号：USD414272S

公开(公告)日：1999-09-21

申请号：US25174

申请日：1994-07-06

Applicant: Raymond E. O'Bear ,  Bruno Colin ,  Garry R. Tegeler ,  John Staples

Designer： Raymond E. O'Bear ,  Bruno Colin ,  Garry R. Tegeler ,  John Staples

公开(公告)号：US5869005A

公开(公告)日：1999-02-09

申请号：US681310

申请日：1996-07-22

Applicant: Raymond E. O'Bear ,  Bruno Colin ,  G. R. Tegeler ,  John L. Staples

Inventor： Raymond E. O'Bear ,  Bruno Colin ,  G. R. Tegeler ,  John L. Staples

IPC: G01N33/52 ,  B01L3/00 ,  B29C45/00 ,  G01N1/28 ,  G01N21/03 ,  G01N35/00 ,  G01N35/02 ,  G01N21/01

CPC classification number: B01L3/502715 ,  B01L3/502 ,  B01L3/5025 ,  B01L3/502723 ,  B29C45/0025 ,  B01L2200/025 ,  B01L2200/0684 ,  B01L2200/0689 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2400/049 ,  G01N2035/00148 ,  Y10T436/111666 ,  Y10T436/112499 ,  Y10T436/113332

Abstract: An improved sample card is provided. The improved card, typically used in biochemical analysis, achieves high sample well capacity and improved fluid flow, including by means of a plurality of through-channels which route the fluid flow of samples along both the front and back surfaces of the card. Elevated bubble traps are provided, as are integral interrupt slots for sensing card position and alignment. A bezeled leading edge facilitates insertion.

Abstract translation: 提供了一个改进的样品卡。 通常用于生物化学分析的改进的卡片实现了高的样品孔容量和改进的流体流动，包括借助于多个通道，其沿着卡的前表面和后表面引导样品的流体流。 提供了高气泡陷阱，作为用于感测卡位置和对准的整体中断槽。 带边缘的前缘有助于插入。

公开(公告)号：US10907190B2

公开(公告)日：2021-02-02

申请号：US13808485

申请日：2011-07-07

Applicant: Vincent Atrache ,  Bruno Colin ,  Aurelie Lafay ,  Bouchra Makrouf ,  Pascal Montes ,  David Mosticone ,  Jean-Claude Raymond ,  Thierry Sofia ,  Antoine Vimont

Inventor： Vincent Atrache ,  Bruno Colin ,  Aurelie Lafay ,  Bouchra Makrouf ,  Pascal Montes ,  David Mosticone ,  Jean-Claude Raymond ,  Thierry Sofia ,  Antoine Vimont

IPC: G01N33/569 ,  C12Q1/04 ,  G01N33/543 ,  G01N33/02

Abstract: The present invention generally relates to the field of analysis for example biological analysis. More specifically, the present invention relates to a process of detecting at least one microorganism present in a sample placed in a closed container, said method comprising essentially the following steps: a) Place said sample in contact in the container with at least one culture medium and a support capable of capturing the microorganism(s) to be detected, b) Close the container, c) Place the container under conditions capable of allowing the growth of the microorganism(s), d) Detect, inside said closed container, using detection means, the presence of the microorganism(s) fixed onto the capture support.

公开(公告)号：US09562260B2

公开(公告)日：2017-02-07

申请号：US12924351

申请日：2010-09-24

Applicant: Bryan W. Kluttz ,  Geoff A. McKinley ,  Fabio Gennari ,  Michel Guy ,  Christopher Cotter ,  Luigi Catazariti ,  Louis Graziano ,  Bruno Colin ,  Cecile Paris ,  Jacque Dachaud

Inventor： Bryan W. Kluttz ,  Geoff A. McKinley ,  Fabio Gennari ,  Michel Guy ,  Christopher Cotter ,  Luigi Catazariti ,  Louis Graziano ,  Bruno Colin ,  Cecile Paris ,  Jacque Dachaud

IPC: B01L3/00 ,  A01B1/00 ,  C12Q1/68 ,  B01L7/00 ,  G01N35/02 ,  G01N35/04

CPC classification number: C12Q1/6848 ,  B01L3/502 ,  B01L7/52 ,  B01L7/525 ,  B01L2200/026 ,  B01L2200/16 ,  B01L2300/044 ,  B01L2300/0809 ,  B01L2300/0825 ,  B01L2300/0861 ,  B01L2300/087 ,  B01L2300/1822 ,  B01L2400/0487 ,  B01L2400/049 ,  B01L2400/0633 ,  B01L2400/0644 ,  B01L2400/0655 ,  G01N35/026 ,  G01N2035/0436

Abstract: An instrument for conducting nucleic acid amplification reactions in a disposable test device. The test device includes a first reaction chamber containing a first nucleic acid amplification reagent (e.g., primers and nucleotides) and a second reaction chamber either containing, or in fluid communication, with a second nucleic acid amplification reagent (e.g., an amplification enzyme such as RT). The instrument includes a support structure receiving the test device. A temperature control system maintains the first reaction chamber at a first elevated temperature but simultaneously maintains the second nucleic acid amplification reagent at a second temperature lower than the first temperature so as to preserve the second nucleic acid amplification reagent. An actuator operates on a fluid conduit in the test device to place the first and second reaction chambers in fluid communication with each other after a reaction has occurred in the first reaction chamber at the first temperature. A pneumatic system is also provided that assists in fluid transfer of a reaction solution from the first chamber to the second chamber.

Abstract translation: 用于在一次性测试装置中进行核酸扩增反应的仪器。 测试装置包括含有第一核酸扩增试剂（例如引物和核苷酸）的第一反应室和含有或与第二核酸扩增试剂（例如，扩增酶如 RT）。 仪器包括接收测试装置的支撑结构。 温度控制系统将第一反应室保持在第一升高温度，同时将第二核酸扩增试剂保持在低于第一温度的第二温度，以便保留第二核酸扩增试剂。 致动器在测试装置中的流体导管上操作，以在第一温度下在第一反应室中发生反应之后使第一和第二反应室彼此流体连通。 还提供了一种有助于将反应溶液从第一室流体转移到第二室的气动系统。

公开(公告)号：US20130236883A1

公开(公告)日：2013-09-12

申请号：US13808485

申请日：2011-07-07

Applicant: Vincent Atrache ,  Bruno Colin ,  Aurelie Lafay ,  Bouchra Makrouf ,  Pascal Montes ,  David Mosticone ,  Jean Claude Raymond ,  Sofia Thierry ,  Antoine Vimont

Inventor： Vincent Atrache ,  Bruno Colin ,  Aurelie Lafay ,  Bouchra Makrouf ,  Pascal Montes ,  David Mosticone ,  Jean Claude Raymond ,  Sofia Thierry ,  Antoine Vimont

IPC: C12Q1/04 ,  G01N33/02

CPC classification number: C12Q1/04 ,  G01N27/026 ,  G01N33/02 ,  G01N33/12 ,  G01N33/5438 ,  G01N33/569

Abstract: The present invention generally relates to the field of analysis for example biological analysis. More specifically, the present invention relates to a process of detecting at least one microorganism present in a sample placed in a closed container, said method comprising essentially the following steps: a) Place said sample in contact in the container with at least one culture medium and a support capable of capturing the microorganism(s) to be detected, b) Close the container, c) Place the container under conditions capable of allowing the growth of the microorganism(s), d) Detect, inside said closed container, using detection means, the presence of the microorganism(s) fixed onto the capture support.

Abstract translation: 本发明一般涉及例如生物分析的分析领域。 更具体地，本发明涉及一种检测放置在密闭容器中的样品中存在的至少一种微生物的方法，所述方法基本上包括以下步骤：a）将所述样品与容器中的至少一种培养基接触 和能够捕获要检测的微生物的载体，b）关闭容器，c）将容器放在能够允许微生物生长的条件下，d）在所述密闭容器内检测使用 检测手段，固定在捕获载体上的微生物的存在。

公开(公告)号：US08518342B2

公开(公告)日：2013-08-27

申请号：US11597867

申请日：2005-06-24

Applicant: David Mosticone ,  Pascal Montes ,  Jean-Claude Raymond ,  Bruno Colin ,  Cecile Paris

Inventor： David Mosticone ,  Pascal Montes ,  Jean-Claude Raymond ,  Bruno Colin ,  Cecile Paris

IPC: G01N21/75

CPC classification number: B01L3/505 ,  B01L2300/044 ,  B01L2300/0663 ,  B01L2300/0672 ,  B01L2300/0825 ,  B01L2400/0406 ,  Y10T436/110833 ,  Y10T436/112499

Abstract: The present invention relates generally to the field of analysis, for example biological analysis. More specifically, the present invention relates to an analysis device (10, 40, 501, 60) designed to be associated with a container (22, 50, 70) containing a sample (28) to be analyzed, said device comprising essentially: a first impervious membrane (12, 42, 52, 62); a second impervious membrane (14, 44, 54, 64) superposed on the first membrane (12, 42, 52, 62); said first and second membranes being fixedly attached over at least a part of their surface, defining a peripheral zone, in order to define an interstitial space forming an internal reaction cavity (16, 46, 56, 66), with no means of fluid communication with the outside of said analysis device (10, 40, 501, 60); at least one analysis means (18, 47, 57, 67), placed inside said internal reaction cavity (16, 46, 56, 66), designed to be placed in contact with the sample (28); at least one means designed to create a way for the sample to enter said internal reaction cavity. The present invention also relates to a container (22, 50, 70) comprising such an analysis device.The present invention also relates to a method of analyzing a sample contained in a container, in which an analysis device according to the invention is used.

Abstract translation: 本发明一般涉及分析领域，例如生物分析。 更具体地说，本发明涉及一种设计成与容纳待分析样品（28）的容器（22,50,70）相关联的分析装置（10,40,501,60），所述装置基本上包括： 第一不透水膜（12,42,52,62）; 叠置在第一膜（12,42,52,62）上的第二不透水膜（14,44,54,64）; 所述第一和第二膜固定地附接在其表面的至少一部分上，限定了周边区域，以便限定形成内部反应腔（16,46,56,66）的间隙空间，没有任何流体连通 与所述分析装置的外部（10,40,501,60）; 放置在与所述样品（28）接触的所述内部反应腔（16,46,56,66）内的至少一个分析装置（18,47,57,67）; 至少一种设计用于创建样品进入所述内部反应腔的方式的装置。 本发明还涉及包括这种分析装置的容器（22,50,70）。 本发明还涉及一种分析包含在容器中的样品的方法，其中使用了根据本发明的分析装置。

公开(公告)号：US07807449B2

公开(公告)日：2010-10-05

申请号：US11438938

申请日：2006-05-22

Applicant: Bryan W. Kluttz ,  Geoff A. McKinley ,  Fabio Gennari ,  Michel Guy ,  Christopher Cotter ,  Luigi Catazariti ,  Louis Graziano ,  Bruno Colin ,  Cecile Paris ,  Jacque Dachaud

Inventor： Bryan W. Kluttz ,  Geoff A. McKinley ,  Fabio Gennari ,  Michel Guy ,  Christopher Cotter ,  Luigi Catazariti ,  Louis Graziano ,  Bruno Colin ,  Cecile Paris ,  Jacque Dachaud

IPC: C12M1/34 ,  C12M3/00 ,  C12M1/36 ,  C12M1/38

CPC classification number: C12Q1/6848 ,  B01L3/502 ,  B01L7/52 ,  B01L7/525 ,  B01L2200/026 ,  B01L2200/16 ,  B01L2300/044 ,  B01L2300/0809 ,  B01L2300/0825 ,  B01L2300/0861 ,  B01L2300/087 ,  B01L2300/1822 ,  B01L2400/0487 ,  B01L2400/049 ,  B01L2400/0633 ,  B01L2400/0644 ,  B01L2400/0655 ,  G01N35/026 ,  G01N2035/0436

Abstract: An instrument for conducting nucleic acid amplification reactions in a disposable test device. The test device includes a first reaction chamber containing a first nucleic acid amplification reagent (e.g., primers and nucleotides) and a second reaction chamber either containing, or in fluid communication, with a second nucleic acid amplification reagent (e.g., an amplification enzyme such as RT). The instrument includes a support structure receiving the test device. A temperature control system maintains the first reaction chamber at a first elevated temperature but simultaneously maintains the second nucleic acid amplification reagent at a second temperature lower than the first temperature so as to preserve the second nucleic acid amplification reagent. An actuator operates on a fluid conduit in the test device to place the first and second reaction chambers in fluid communication with each other after a reaction has occurred in the first reaction chamber at the first temperature. A pneumatic system is also provided that assists in fluid transfer of a reaction solution from the first chamber to the second chamber.

Abstract translation: 用于在一次性测试装置中进行核酸扩增反应的仪器。 测试装置包括含有第一核酸扩增试剂（例如引物和核苷酸）的第一反应室和含有或与第二核酸扩增试剂（例如，扩增酶如 RT）。 仪器包括接收测试装置的支撑结构。 温度控制系统将第一反应室保持在第一升高温度，同时将第二核酸扩增试剂保持在低于第一温度的第二温度，以便保留第二核酸扩增试剂。 致动器在测试装置中的流体导管上操作，以在第一温度下在第一反应室中发生反应之后使第一和第二反应室彼此流体连通。 还提供了一种有助于将反应溶液从第一室流体转移到第二室的气动系统。

公开(公告)号：US07587977B2

公开(公告)日：2009-09-15

申请号：US10585356

申请日：2005-01-20

Applicant: Patrick Broyer ,  Bruno Colin ,  Denis Roller

Inventor： Patrick Broyer ,  Bruno Colin ,  Denis Roller

IPC: F15B15/19

CPC classification number: F16K99/0001 ,  F15B15/19 ,  F15C5/00 ,  F16K99/0015 ,  F16K99/0067 ,  F16K2099/008 ,  F42B3/04 ,  F42C19/06 ,  F42C19/12 ,  Y10T428/261 ,  Y10T428/31

Abstract: The invention relates to a microsystem and a method for fabricating a microsystem. The pyrotechnic microsystem (7, 1′) comprises a substrate having at least two separate electrical initiation zones, each of which provides separate electrical initiation of a pyrotechnic material deposited on the substrate. This microsystem (7, 1′) is characterized in that the same pyrotechnic material deposit (721, 721′, 13) covers both initiation zones, said deposit (721, 721′, 13) produced on the substrate having a thickness sufficiently small for the initiation of the pyrotechnic material in the initiation zone to remain localized and not propagate to the other initiation zone, but sufficient to generate a specific gas quantity.

Abstract translation: 本发明涉及微系统和微系统的制造方法。 烟火微系统（7,1'）包括具有至少两个分开的电引发区的衬底，每个电引发区提供沉积在衬底上的烟火材料的单独的电引发。 该微系统（7,1'）的特征在于，相同的烟火材料沉积物（721,721'，13）覆盖两个起始区域，所述沉积物（721,721'，13）在基板上产生的厚度足够小， 起始区域中的烟火材料的起始保持局部化并且不会传播到另一个起始区，但足以产生特定的气体量。

公开(公告)号：US07396690B2

公开(公告)日：2008-07-08

申请号：US10483121

申请日：2002-07-09

Applicant: Bruno Colin

Inventor： Bruno Colin

IPC: G01N33/553

CPC classification number: B03C1/288 ,  B03C1/035 ,  G01N35/0098

Abstract: A method for treating magnetic particles present in a solution in a container by redispersion, rinsing or displacement, the particles having novel characteristics under the effect of a specific magnet and being associated or not with biological entities. The magnetic particles undergo at least one low-intensity magnetization where they are disposed in filaments oriented according to the north-south axis of the magnet; the magnetization source and/or container is/are displaced while the magnetic effect is maintained on the magnetic particles; the magnetization source and/or container is/are displaced or the, magnetization is stopped, in order to suppress the magnetic field on the magnetic particles. Preferably, the invention can be used in the field of biology.

Abstract translation: 用于通过再分散，漂洗或置换来处理存在于容器中的溶液中的磁性颗粒的方法，所述颗粒在特定磁体的作用下具有新特性并且与生物实体相关联。 磁性颗粒经历至少一个低强度磁化，其中它们设置在根据磁体的南北轴线取向的长丝中; 当磁效应保持在磁性颗粒上时，磁化源和/或容器被移位; 磁化源和/或容器被移位或磁化被停止，以便抑制磁性颗粒上的磁场。 优选地，本发明可以用于生物学领域。

公开(公告)号：US07270059B2

公开(公告)日：2007-09-18

申请号：US10552583

申请日：2004-04-09

Applicant: Denis Roller ,  Patrick Broyer ,  Bruno Colin

Inventor： Denis Roller ,  Patrick Broyer ,  Bruno Colin

IPC: F42B3/10

CPC classification number: F42B3/10 ,  F41A19/65 ,  F42B3/006 ,  F42C19/12

Abstract: The invention relates to a device for the electrical initiation of at least one pyrotechnic microcharge (3), this device being characterized in that it comprises a support element having at least one conductive finger (6) connected to a first terminal of a central control unit (8), a second terminal of said central control unit (8) being intended to be electrically connected to an electrically conductive support for the pyrotechnic microcharge (3). The invention also relates to a microactuator (1, 1a, . . . , 1h) and a microsystem (1′) that use such an initiation device.

Abstract translation: 本发明涉及一种用于电启动至少一个烟火微电池（3）的装置，该装置的特征在于其包括具有至少一个导电指状物（6）的支撑元件，该导电指状物（6）连接到中央控制单元 （8），所述中央控制单元（8）的第二端子旨在电连接到用于烟火微电池（3）的导电支撑件。 本发明还涉及使用这种引发装置的微致动器（1,1a，...，1h）和微系统（1'）。