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    SYSTEM AND METHOD FOR SPECTROSCOPY AND IMAGING
    11.
    发明申请
    SYSTEM AND METHOD FOR SPECTROSCOPY AND IMAGING 审中-公开
    用于光谱和成像的系统和方法

    公开(公告)号：WO2006007064A2

    公开(公告)日：2006-01-19

    申请号：PCT/US2005/016141

    申请日：2005-05-06

    Applicant: CHEMIMAGE CORPORATION ,  STEWART, Shona ,  NELSON, Matthew, P. ,  DEMUTH, Joseph, E. ,  TREADO, Patrick, J.

    Inventor： STEWART, Shona ,  NELSON, Matthew, P. ,  DEMUTH, Joseph, E. ,  TREADO, Patrick, J.

    IPC: G01J3/44 ,  G01N21/65

    CPC classification number: G01J3/44 ,  G01J3/0297 ,  G01N21/65

    Abstract: The disclosure relates to a substrate material for the improved detection, resolution and imaging of biological material for spectroscopic characterization by Raman of optical imaging spectroscopy. The substrate provides a uniform, optically flat, highly reflective surface which can be made hydrophobic to prevent spreading of the sample and facilitating its optical evaluation. Moreover, the substrate can be coated with a material that does not emit Raman scattered photons when exposed to said illuminating photons. The principles disclosed herein allow a low spectroscopic background particularly suitable for examining small samples or samples having low concentrations of the suspected component.

    Abstract translation: 本公开涉及用于通过光学成像光谱的拉曼的光谱表征的生物材料的改进的检测，分辨和成像的基底材料。 衬底提供均匀的光学平坦的高反射表面，其可以被制成疏水性以防止样品的扩散并且便于其光学评估。 此外，当暴露于所述照射光子时，衬底可以涂覆有不发射拉曼散射光子的材料。 本文公开的原理允许低光谱背景特别适合于检查具有低浓度可疑成分的小样品或样品。

    AUTOMATED ACQUISITION OF SPECTRAL DATA AND IMAGE DATA
    15.
    发明申请
    AUTOMATED ACQUISITION OF SPECTRAL DATA AND IMAGE DATA 审中-公开
    自动采集光谱数据和图像数据

    公开(公告)号：WO2007050602A2

    公开(公告)日：2007-05-03

    申请号：PCT/US2006/041471

    申请日：2006-10-24

    Applicant: CHEMIMAGE CORPORATION ,  MAIER, John, S. ,  TREADO, Patrick, J. ,  NELSON, Matthew ,  MCCLELLAND, Lindy ,  STEWART, Shona

    Inventor： MAIER, John, S. ,  TREADO, Patrick, J. ,  NELSON, Matthew ,  MCCLELLAND, Lindy ,  STEWART, Shona

    IPC: H04B10/08 ,  H04B17/00

    CPC classification number: G01N21/65 ,  G01J3/28 ,  G01J3/2823 ,  G01J3/44 ,  G01N21/274 ,  G01N2021/656

    Abstract: A system and method to automatically obtain spectra for samples. The method involves a two phase process including a photobleaching phase and a spectral acquisition phase. In the photobleaching phase, a series of spectral data sets of a sample are collected. A relative difference is determined between the background of subsequent spectral data sets is determined and compared to a predetermined threshold value. If threshold difference is less than the relative difference between the background of subsequent spectral data sets, the steps of collecting a series of spectra data sets is automatically repeated. In the spectrum acquisition phase, a series of Raman data sets of the sample are collected until a target SNR is obtained.

    Abstract translation: 自动获取样品光谱的系统和方法。 该方法涉及包括光漂白相和光谱采集阶段的两相过程。 在漂白漂白阶段，收集样品的一系列光谱数据集。 在确定后续光谱数据集的背景并将其与预定阈值进行比较之间确定相对差。 如果阈值差小于随后的光谱数据集的背景之间的相对差，则自动重复收集一系列光谱数据集的步骤。 在频谱采集阶段，收集样本的一系列拉曼数据集，直到获得目标SNR。

    SYSTEMS AND METHODS FOR DETECTING EDEMA
    19.
    发明申请
    SYSTEMS AND METHODS FOR DETECTING EDEMA 审中-公开
    用于检测EDEMA的系统和方法

    公开(公告)号：WO2018009670A1

    公开(公告)日：2018-01-11

    申请号：PCT/US2017/040910

    申请日：2017-07-06

    Applicant: CHEMIMAGE CORPORATION

    Inventor： STEWART, Shona ,  POST, J. Christopher ,  TREADO, Patrick ,  COHEN, Jeffrey

    IPC: A61B5/00 ,  A61B5/05 ,  A61B5/1455 ,  G01J3/28 ,  G01N21/17 ,  G02F1/1335

    Abstract: System and method for detecting and monitoring edema in a patient are described. Initially, a patient's tissue is irradiated with light by a light source. A detector collects reflected light from the patient's tissue and generates data associated with the reflected light. A processing device receives the data and reflected light and calculates an intensity of the reflected light. The processing device then determined, based upon the intensity of the reflected light, whether the patient's tissue exhibits any symptoms of edema. Additionally, the processing device can compare a current intensity of the reflected light against historic information to monitor for any changes in a patient's edema level or severity.

    Abstract translation: 描述了用于检测和监测患者水肿的系统和方法。 最初，患者的组织用光源照射光线。 检测器收集来自患者组织的反射光并生成与反射光相关的数据。 处理装置接收数据和反射光并计算反射光的强度。 处理装置然后基于反射光的强度来确定患者的组织是否表现出任何水肿症状。 另外，处理设备可以将反射光的当前强度与历史信息进行比较，以监测患者水肿水平或严重程度的任何变化。

    RAMAN-BASED IMMUNOASSAY SYSTEMS AND METHODS
    20.
    发明申请
    RAMAN-BASED IMMUNOASSAY SYSTEMS AND METHODS 审中-公开
    基于拉曼的免疫系统和方法

    公开(公告)号：WO2017087574A1

    公开(公告)日：2017-05-26

    申请号：PCT/US2016/062361

    申请日：2016-11-16

    Applicant: CHEMIMAGE CORPORATION

    Inventor： TREADO, Patrick ,  STEWART, Shona ,  SMITH, Aaron ,  GOMER, Heather

    IPC: G01J3/44 ,  A61B6/00 ,  G01N21/17 ,  G01N21/65 ,  G01N33/53

    CPC classification number: G01N21/65 ,  G01J3/44 ,  G01N2201/0833

    Abstract: This disclosure is directed to systems and methods for fusing Raman data with biomarker data to identify a disease and/or the progression of the disease. The system disclosed herein may include an illumination source for generating interacted photons from a biological sample and a detector for detecting the interacted photons to generate a Raman data set. A processor is included to fuse the Raman data set with a biomarker data set to identify a disease and/or a disease progression. The instant disclosure further includes a method comprising illuminating a biological sample to generate interacted photons, and detecting the interacted photons to generate a Raman data set. A biomarker data set is obtained from the biological sample, and the Raman data set is fused with the biomarker data set to generate an index score. The index score correlates with one or more of a disease and a disease progression.

    Abstract translation: 本公开涉及用于将拉曼数据与生物标志数据融合以鉴定疾病和/或疾病进展的系统和方法。 本文公开的系统可以包括用于生成来自生物样本的相互作用的光子的照射源和用于检测相互作用的光子以生成拉曼数据集的检测器。 包括处理器以将拉曼数据组与生物标志物数据组融合以识别疾病和/或疾病进展。 本公开还包括一种方法，该方法包括照射生物样本以生成相互作用的光子，并且检测相互作用的光子以生成拉曼数据集。 从生物样品获得生物标记数据集，并将拉曼数据集与生物标记数据集融合以产生指数分数。 指数评分与一种或多种疾病和疾病进展相关。

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