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公开(公告)号：EP3417472A1
公开(公告)日：2018-12-26
申请号：EP17752799.1
申请日：2017-02-15
Applicant: Convergent R.N.R Ltd
Inventor： BAR-DAVID, Aharon , BURSHTEIN, Zeev , KELLER, Avigail , HAREL, Zeev
CPC classification number: A61N5/1071 , A61B6/542 , A61N5/1075
Abstract: A method of evaluating a maximal dose deposited by an X-ray beam within a medium comprises the steps of: (a) irradiating said medium by said X-rays beam penetrating into a depth of said medium along an axis of said X-ray beam; (b) measuring a dose distribution along said axis. The step of measuring said dose distribution further comprises measuring cross-sectional distributions with a predetermined incremental shift thereof along said beam axis, and calculating a 1-dimensional function of said maximal dose in dependence on said depth taken from maximum dose at each cross-sectional distribution at each depth.
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公开(公告)号：EP3180085A1
公开(公告)日：2017-06-21
申请号：EP15832565.4
申请日：2015-08-12
Applicant: Convergent R.N.R Ltd
Inventor： HAREL, Zeev , BURSHTEIN ZEEV, Zeev , BAR-DAVID, Aharon , MARKOVICH, Miri
CPC classification number: A61M37/00 , A61K9/0009 , A61K41/00 , A61K41/0052 , A61M2037/0007 , A61N5/10 , A61N2005/1091 , A61N2005/1098
Abstract: The present invention provides a method for activating a pro-drug in vivo comprising the steps of: (a) administering a pro-drag to a subject; (b) locating a target site which has been at least partially dosed with the pro-drug at a predetermined concentration; and (d) exposing the target site to X-ray radiation. The step of exposing the target site to X-ray radiation is characterized by providing a converging X-ray of a controllable waist, substantially uniform at the target site, sufficient to convert the pro-drug to an active drug, while the X-ray photon dosage at the target site is higher than the X-ray photon dosage at an adjacent non target site.
Abstract translation: 本发明提供了一种活体内激活前体药物的方法，其包括以下步骤：（a）将前体药物施用于受试者; （b）将已经至少部分用前药给药的靶位点定位在预定浓度; 和（d）将目标部位暴露于X射线辐射。 使目标部位暴露于X射线辐射的步骤的特征在于提供可控腰部的会聚X射线，其在目标部位基本均匀，足以将前药转化为活性药物，而X射线 目标部位的光子剂量高于相邻非目标部位的X射线光子剂量。
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公开(公告)号：EP2898361A1
公开(公告)日：2015-07-29
申请号：EP13839717.9
申请日：2013-09-01
Applicant: Convergent R.N.R Ltd
Inventor： BAR-DAVID, Aharon , BURSHTEIN, Zeev , HAREL, Zeev
CPC classification number: G21K1/062 , A61N5/1042 , A61N5/1084 , A61N2005/1091 , A61N2005/1095 , G21K5/04 , G21K2201/064
Abstract: An X-ray lens arrangement for forming a radiation pattern as a focal track is disclosed. The pattern comprises at least one 3-dimensional focal track of radiation. The aforesaid lens arrangement has a main axis passing through intensity weighted centroids of the X-ray source and the pattern. The lens arrangement includes at least one reflecting surface of continuously varying Rowland arcs. Each point belonging to the focal track is linked to each elemental point composing an emitting surface of said source by a corresponding Rowland arc.
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公开(公告)号：EP4035186A1
公开(公告)日：2022-08-03
申请号：EP20867660.1
申请日：2020-09-23
Applicant: Convergent R.N.R Ltd
Inventor： BORUKHIN, Shirly , KLECKNER, Michael , BAR-DAVID, Aharon , HAREL, Zeev
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Patent Agency Ranking
公开(公告)号：EP2814573B1
公开(公告)日：2018-03-21
申请号：EP13749498.5
申请日：2013-02-10
Applicant: Convergent R.N.R Ltd
Inventor： BURSHTEIN, Zeev , HAREL, Zeev , BAR-DAVID, Aharon , KORN, Donald M.
CPC classification number: A61N5/1049 , A61B6/06 , A61B6/4021 , A61B6/4035 , A61B6/483 , A61N5/1065 , A61N5/1077 , A61N5/1084 , A61N2005/1054 , A61N2005/1061 , A61N2005/1091 , A61N2005/1095 , G21K1/04 , G21K1/065 , G21K1/067 , G21K2201/064 , H05G1/70
Abstract: An X-ray system comprises: (a) a source providing an X-ray diverging beam having treatment and imaging angular portions; (b) one or more lenses transforming the treatment portion of the X-ray beam into a converging beam directed to a target; (c) a first shutter located between the X-ray source and the target in the imaging portion of the X-ray radiation; the first shutter being selectively openable such that imaging portion of X-ray beam reaches the target; and (d) a detector configured to detect at least a portion of the imaging radiation after the imaging radiation has interacted with the target to provide imaging information of the target.
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公开(公告)号：EP3952987A1
公开(公告)日：2022-02-16
申请号：EP20787593.1
申请日：2020-04-07
Applicant: Convergent R.N.R Ltd.
Inventor： ZUCK, Asaf , BURSHTEIN, Zeev , BAR-DAVID, Aharon , HAREL, Zeev , KLECKNER, Michael , BORUKHIN, Shirly
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公开(公告)号：EP3180085B1
公开(公告)日：2020-10-07
申请号：EP15832565.4
申请日：2015-08-12
Applicant: Convergent R.N.R Ltd
Inventor： HAREL, Zeev , BURSHTEIN ZEEV, Zeev , BAR-DAVID, Aharon , MARKOVICH, Miri
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公开(公告)号：EP3646346A1
公开(公告)日：2020-05-06
申请号：EP18823905.7
申请日：2018-06-28
Applicant: Convergent R.N.R Ltd.
Inventor： BAR-DAVID, Aharon , MARKOVICH, Miri , KELLER, Avigail , BURSHTEIN, Zeev , HAREL, Zeev
IPC: G21K1/06 , A61N5/00 , G01N23/083
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公开(公告)号：EP2814573A1
公开(公告)日：2014-12-24
申请号：EP13749498.5
申请日：2013-02-10
Applicant: Convergent R.N.R Ltd
Inventor： BURSHTEIN, Zeev , HAREL, Zeev , BAR-DAVID, Aharon , KORN, Donald M.
CPC classification number: A61N5/1049 , A61B6/06 , A61B6/4021 , A61B6/4035 , A61B6/483 , A61N5/1065 , A61N5/1077 , A61N5/1084 , A61N2005/1054 , A61N2005/1061 , A61N2005/1091 , A61N2005/1095 , G21K1/04 , G21K1/065 , G21K1/067 , G21K2201/064 , H05G1/70
Abstract: An X-ray system comprises: (a) a source providing an X-ray diverging beam having treatment and imaging angular portions; (b) one or more lenses transforming the treatment portion of the X-ray beam into a converging beam directed to a target; (c) a first shutter located between the X-ray source and the target in the imaging portion of the X-ray radiation; the first shutter being selectively openable such that imaging portion of X-ray beam reaches the target; and (d) a detector configured to detect at least a portion of the imaging radiation after the imaging radiation has interacted with the target to provide imaging information of the target.
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