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公开(公告)号：EP2981308A4
公开(公告)日：2016-11-16
申请号：EP14779243
申请日：2014-03-31
Applicant: CYTOSORBENTS CORP
Inventor： GOLOBISH THOMAS D , CAPPONI VINCENT J , CLAY DAVID R
CPC classification number: A61M1/3679 , A01N1/02 , A01N1/0215 , A61M1/0272 , A61M1/34 , A61M1/36 , B01J20/261 , B01J20/267 , B01J20/28069 , B01J20/28078 , B01J20/28092 , B01J20/3208 , B01J20/3246 , B01J20/3248 , B01J20/3251 , B01J20/3272 , B01J20/3282 , B01J20/3285 , B01J2220/62
Abstract: The invention concerns methods of treating blood, blood product, or physiologic fluid to provide at least one of (i) increasing shelf life of the blood, blood product or physiologic fluid, (ii) maintaining freshness of new blood, blood product or physiologic fluid, and (iii) removing undesirable molecules from the blood, blood product or physiologic fluid; said method comprising contacting said blood, blood product or physiologic fluid with a sorbent, said sorbent being primarily in a plurality of solid forms and comprising a cross-linked polymeric material having a plurality of at least one of (1) zwitterionic moieties and (2) oligo(ethylene glycol) moieties attached to the surface of said cross-linked polymeric material.
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公开(公告)号：CA2823772C
公开(公告)日：2019-03-12
申请号：CA2823772
申请日：2012-01-06
Applicant: CYTOSORBENTS CORP
Inventor： CHAN PHILLIP P , CAPPONI VINCENT J , GOLOBISH THOMAS D , ALI HUMAYRA BEGUM
Abstract: The invention concerns polymer systems comprising at least one polymer with a plurality of pores where the polymer is initially functionalized on substantially all surfaces followed by a stepwise surface specific functionalization such that a different functional group resides on the external or internal pore surface of the bead. The invention also concerns use of such polymer systems in blood, blood product, or physiologic fluid purification.
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公开(公告)号：AU2013282320B2
公开(公告)日：2017-10-19
申请号：AU2013282320
申请日：2013-06-28
Applicant: CYTOSORBENTS CORP
Inventor： CHAN PHILLIP P , CAPPONI VINCENT J , GOLOBISH THOMAS D , ALI HUMAYRA BEGUM
Abstract: Provided herein are materials and methods of reducing contamination in a biological substance or treating contamination in a subject by one or more toxins comprising contacting the biological substance with an effective amount of a sorbent capable of sorbing the toxin, wherein the sorbent comprises a plurality of pores ranging from 50Å to 40,000Å with a pore volume of 0.5 cc/g to 5.0 cc/g and a size of 0.05 mm to 2 cm and sorbing the toxin. Also provided are kits to reduce contamination by one or more toxins in a biological substance comprising a sorbent capable of sorbing a toxin, wherein the sorbent comprises a plurality of pores ranging from 50Å to 40,000Å with a pore volume of 0.5 cc/g to 5.0 cc/g and a size of 0.05 mm to 2 cm and a vessel to store said sorbent when not in use together with packaging for same.
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公开(公告)号：AU2012295350B2
公开(公告)日：2016-09-22
申请号：AU2012295350
申请日：2012-08-10
Applicant: CYTOSORBENTS CORP
Inventor： CHAN PHILLIP P , CAPPONI VINCENT J , GOLOBISH THOMAS D , ALI HUMAYRA BEGUM
Abstract: The invention concerns methods of treating stored blood and blood products maximizing shelf life and/or minimizing transfusion related complications such as non¬ hemolytic transfusion reactions such as fever, transfusion-related acute lung injury (TRALI), transfusion associated dyspnea (TAD), and allergic reactions by removing undesirable molecules in the blood and blood products milieu through use of a sorbent.
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公开(公告)号：CA2823772A1
公开(公告)日：2012-07-12
申请号：CA2823772
申请日：2012-01-06
Applicant: CYTOSORBENTS CORP
Inventor： CHAN PHILLIP P , CAPPONI VINCENT J , GOLOBISH THOMAS D , ALI HUMAYRA BEGUM
IPC: B32B5/16
Abstract: The invention concerns polymer systems comprising at least one polymer with a plurality of pores where the polymer is initially functionalized on substantially all surfaces followed by a stepwise surface specific functionalization such that a different functional group resides on the external or internal pore surface of the bead. The invention also concerns use of such polymer systems in blood, blood product, or physiologic fluid purification.
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Patent Agency Ranking
公开(公告)号：EP2866854A4
公开(公告)日：2016-03-30
申请号：EP13810619
申请日：2013-06-28
Applicant: CYTOSORBENTS CORP
Inventor： CHAN PHILLIP P , CAPPONI VINCENT J , GOLOBISH THOMAS D , ALI HUMAYRA BEGUM
CPC classification number: A61M1/3679 , A61K9/16 , A61K31/765 , A61M2202/0057 , A61M2202/0405 , A61M2202/0413 , A61M2202/0415 , A61M2202/0423 , A61M2202/0464 , A61M2202/0466 , A61M2202/049 , A61M2202/0492 , A61M2202/0496 , A61M2202/20 , A61M2202/203 , A61M2202/206 , B01J20/261 , B01J20/28069 , B01J20/28078 , C08F299/00 , C08J9/26 , C08J2201/0444 , C08J2207/10 , C08J2353/00
Abstract: Provided herein are materials and methods of reducing contamination in a biological substance or treating contamination in a subject by one or more toxins comprising contacting the biological substance with an effective amount of a sorbent capable of sorbing the toxin, wherein the sorbent comprises a plurality of pores ranging from 50 Å to 40,000 Å with a pore volume of 0.5 cc/g to 5.0 cc/g and a size of 0.05 mm to 2 cm and sorbing the toxin. Also provided are kits to reduce contamination by one or more toxins in a biological substance comprising a sorbent capable of sorbing a toxin, wherein the sorbent comprises a plurality of pores ranging from 50 Å to 40,000 Å with a pore volume of 0.5 cc/g to 5.0 cc/g and a size of 0.05 mm to 2 cm and a vessel to store said sorbent when not in use together with packaging for same.
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公开(公告)号：CA2795177C
公开(公告)日：2018-07-03
申请号：CA2795177
申请日：2011-04-01
Applicant: CYTOSORBENTS CORP
Inventor： CHAN PHILLIP P , YOUNG WEI-TAI , CAPPONI VINCENT J , GOLOBISH THOMAS D , BARTLETT ROBERT H , ALI HUMAYRA BEGUM
IPC: A61K31/74 , A61K31/717 , A61P29/00
Abstract: The present invention concerns methods of treating systemic, regional, or local inflammation from a patient suffering or at risk of inflammation comprising administration of a therapeutically effective dose of a sorbent that sorbs an inflammatory mediator in said patient. In some preferred embodiments, the sorbent is a biocompatible organic polymer.
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公开(公告)号：CA2963458A1
公开(公告)日：2016-04-07
申请号：CA2963458
申请日：2015-10-02
Applicant: CYTOSORBENTS CORP
Inventor： ALI HUMAYRA BEGUM , GOLOBISH THOMAS D , CAPPONI VINCENT J , CHAN PHILLIP P , YOUNG WEI-TAI , SCHEIRER ANDREW ROBERT
IPC: A61K31/74 , A61K31/745 , A61K31/75 , C08F236/20
Abstract: Disclosed herein are compositions and methods for preventing or treating acute or chronic oral mucositis, esophagitis, enteritis, colitis, or gastrointestinal acute radiation syndrome (GI-ARS) caused by radiation exposure, using one or more enteron sorbent polymers administered gastrointestinally (e.g. orally, via feeding or gastric tube, via ostomy, or rectally).
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公开(公告)号：AU2011234978A1
公开(公告)日：2012-10-18
申请号：AU2011234978
申请日：2011-04-01
Applicant: CYTOSORBENTS CORP
Inventor： CHAN PHILLIP P , YOUNG WEI-TAI , CAPPONI VINCENT J , GOLOBISH THOMAS D , BARLETT ROBERT H
IPC: A61K31/74
Abstract: The present invention concerns methods of treating systemic, regional, or local inflammation from a patient suffering or at risk of inflammation comprising administration of a therapeutically effective dose of a sorbent that sorbs an inflammatory mediator in said patient. In some preferred embodiments, the sorbent is a biocompatible organic polymer.
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公开(公告)号：CA2823953C
公开(公告)日：2023-01-03
申请号：CA2823953
申请日：2012-01-06
Applicant: CYTOSORBENTS CORP
Inventor： CHAN PHILLIP P , CAPPONI VINCENT J , GOLOBISH THOMAS D , ALI HUMAYRA BEGUM
Abstract: Methods of treating blood, blood products or physiologic fluid maximize shelf life and/or minimize transfusion related complications such as non-hemolytic transfusion reactions such as fever, transfusion-related acute lung injury (TRALI), transfusion associated dyspnea (TAD), and allergic reactions by removing undesirable molecules in the blood, blood product or physiologic fluid milieu through use of a sorbent. The blood purification devices comprise: (a) a compliant container suitable for the storage of blood, blood product or physiologic fluid; (b) sorbent comprising hemocompatible material suitable for treating blood, blood product or physiologic fluid, the sorbent performing at least one of (i) increasing shelf life of the blood, blood product or physiologic fluid, (ii) maintaining freshness of new blood, blood product or physiologic fluid, and (iii) removing undesirable molecules from the blood, blood product or physiologic fluid; where the sorbent is contained within the compliant container.
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