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公开(公告)号：US09783775B2
公开(公告)日：2017-10-10
申请号：US15432737
申请日：2017-02-14
Applicant: FloDesign Sonics, Inc.
Inventor： Bart Lipkens , Louis Masi , Stanley Kowalski, III , Walter M. Presz, Jr. , Jason Dionne , Brian Dutra , Ari Mercado , Thomas J. Kennedy, III , Arthur Martin
CPC classification number: C12M47/02 , B01D17/04 , B01D17/06 , B01D21/283 , B01J19/10 , B01J19/18 , B06B1/0644 , C02F1/36 , C02F3/00 , C12M23/14 , C12M23/22 , C12M27/02 , C12M29/10 , C12M29/18 , C12M33/08 , C12M33/14 , C12M35/04 , C12M47/10
Abstract: A perfusion bioreactor includes at least one ultrasonic transducer that can acoustically generate a multi-dimensional standing wave. The standing wave can be used to retain cells in the bioreactor, and can also be utilized to dewater or further harvest product from the waste materials produced in a bioreactor.
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公开(公告)号：US20170217794A1
公开(公告)日：2017-08-03
申请号：US15490878
申请日：2017-04-18
Applicant: FLODESIGN SONICS, INC.
Inventor： Bart Lipkens , Walter M. Presz, JR. , Kedar Chitale , Brian McCarthy , Benjamin Ross-Johnsrud , Thomas J. Kennedy, III , Dane Mealey , Brian Dutra , David Sokolowski
CPC classification number: C02F1/36 , B01D17/04 , B01D17/041 , B01D17/044 , B01D19/0078 , B01D21/28 , B06B1/0622 , B06B1/0644 , C02F1/40 , C12M35/04 , C12M47/02 , C12N1/02 , C12N13/00 , G10K11/28 , H01L41/0913
Abstract: Separation of particles or droplets from a host fluid may be achieved using a transducer and/or reflector that is a thin, non-planar structure. The thin non-planar structure improves operation of an acoustic standing wave generated by an acoustic transducer. The structure may operate as a pressure release boundary and may be constructed as plastic film.
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公开(公告)号：US20170175073A1
公开(公告)日：2017-06-22
申请号：US15453582
申请日：2017-03-08
Applicant: FloDesign Sonics, Inc.
Inventor： Bart Lipkens , Louis Masi , Stanley Kowalski, III , Walter M. Presz, JR. , Jason Dionne , Brian Dutra , Ari Mercado , Thomas J. Kennedy, III , Arthur Martin , John Rozembersky
IPC: C12M1/00
CPC classification number: C12M47/10 , B01D17/04 , B01D17/06 , B01D21/283 , B01J19/10 , B01J19/18 , B01J2219/00094 , B06B1/0644 , C12M23/14 , C12M23/22 , C12M27/02 , C12M29/10 , C12M29/18 , C12M33/08 , C12M33/14 , C12M35/04 , C12M47/02
Abstract: A perfusion bioreactor includes at least one ultrasonic transducer that can acoustically generate a multi-dimensional standing wave. The standing wave can be used to retain cells in the bioreactor, and can also be utilized to dewater or further harvest product from the waste materials produced in a bioreactor.
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公开(公告)号：US09272234B2
公开(公告)日：2016-03-01
申请号：US13943529
申请日：2013-07-16
Applicant: FloDesign Sonics Inc.
Inventor： Bart Lipkens , Jason Dionne , Ari Mercado , Brian Dutra , Walter M. Presz, Jr. , Thomas J. Kennedy, III , Louis Masi
CPC classification number: B01D17/04 , B01D43/00 , B06B1/0644 , C12M47/02
Abstract: An acoustic standing wave is utilized to separate components from a multi-component fluid, such as oil from an oil-water mixture, in a fluid flow scheme with an acoustophoresis device. For example, the flow scheme and device allows for trapping of the oil as the oil coalesces, agglomerates, and becomes more buoyant than the water.
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公开(公告)号：US20150274550A1
公开(公告)日：2015-10-01
申请号：US14711627
申请日：2015-05-13
Applicant: FloDesign Sonics Inc.
Inventor： Bart Lipkens , Jason Dionne , Ari Mercado , Brian Dutra , Walter M. Presz, JR. , Thomas J. Kennedy, III , Louis Masi
CPC classification number: C02F1/36 , B01D17/045 , B01D17/12 , B01D21/283 , B01D43/00 , B06B1/0644 , C02F1/40 , C02F2103/007 , C02F2103/10
Abstract: An acoustic standing wave is utilized to separate components from a multi-component fluid, such as oil from an oil-water mixture, in a fluid flow scheme with an acoustophoresis device. For example, the flow scheme and device allows for trapping of the oil as the oil coalesces, agglomerates, and becomes more buoyant than the water.
Abstract translation: 使用声驻波在具有声流装置的流体流动方案中将组分与多组分流体（例如来自油 - 水混合物的油）分离。 例如，流动方案和装置允许在油聚结，聚集并且变得比水更浮力时捕获油。
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Patent Agency Ranking
公开(公告)号：US20140154795A1
公开(公告)日：2014-06-05
申请号：US14175766
申请日：2014-02-07
Applicant: FloDesign Sonics, Inc.
Inventor： Bart Lipkens , Louis Masi , Stanley Kowalski, III , Walter M. Presz, JR. , Jason Dionne , Brian Dutra , Ari Mercado , Thomas J. Kennedy, III , Arthur Martin
IPC: C12M1/12
CPC classification number: C12M25/00 , B01D17/04 , B01D17/06 , B01D21/283 , B06B1/0644 , C12M29/10 , C12M33/08 , C12M35/04 , C12M47/02 , H01L41/0973
Abstract: A perfusion bioreactor includes at least one ultrasonic transducer that can acoustically generate a multi-dimensional standing wave. The standing wave can be used to retain cells in the bioreactor, and can also be utilized to dewater or further harvest product from the waste materials produced in a bioreactor.
Abstract translation: 灌注生物反应器包括至少一个可声学地产生多维驻波的超声换能器。 驻波可用于将细胞保留在生物反应器中，并且也可用于从生物反应器中生产的废物中脱水或进一步收获产品。
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公开(公告)号：US20220379310A1
公开(公告)日：2022-12-01
申请号：US17804211
申请日：2022-05-26
Applicant: FloDesign Sonics, Inc.
Inventor： Brian Dutra , Christopher Jurkiewicz , Brian McCarthy , Richard Grant , Jeffrey King , Bart Lipkens , Yasser Ali , Stefano Berti Perez
Abstract: A workstation for processing particles entrained in a fluid includes a consumable portion and a reusable portion. The consumable portion is mounted to the reusable portion to form a fluid chamber in which an acoustic wave can be generated. The consumable portion implements a closed, isolated fluid environment that is managed using components of the reusable portion, such as valves, sensors and pumps. The workstation can be operated to retain particles from the fluid via the acoustic wave and provide a new fluid media to the retained particles. Following processing, the consumable portion can be removed and discarded.
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公开(公告)号：US20190276815A1
公开(公告)日：2019-09-12
申请号：US15916270
申请日：2018-03-08
Applicant: FloDesign Sonics, Inc.
Inventor： Bart Lipkens , Rui Tostoes , Brian Dutra , Rudolf Gilmanshin , Jason Dionne , Walter M. Presz, JR. , Benjamin Ross-Johnsrud , Goutam Ghoshal , Kedar Chitale
Abstract: A closed and modular fluidic system composed of one or more acoustic elements and cell processing reagents. The system employs a cellular manufacturing process for producing cell and gene therapy therapeutics.
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公开(公告)号：US20170159007A1
公开(公告)日：2017-06-08
申请号：US15432888
申请日：2017-02-14
Applicant: FloDesign Sonics, Inc.
Inventor： Bart Lipkens , Louis Masi , Stanley Kowalski, III , Walter M. Presz, JR. , Jason Dionne , Brian Dutra , Ari Mercado , Thomas J. Kennedy, III , Arthur Martin
IPC: C12M1/00
CPC classification number: C12M47/10 , B01D17/04 , B01D17/06 , B01D21/283 , B06B1/0644 , C12M23/14 , C12M23/22 , C12M27/00 , C12M27/02 , C12M29/18 , C12M33/08 , C12M33/14 , C12M35/04 , C12M47/02 , C12M47/04 , C12P21/02
Abstract: A perfusion bioreactor includes at least one ultrasonic transducer that can acoustically generate a multi-dimensional standing wave. The standing wave can be used to retain cells in the bioreactor, and can also be utilized to dewater or further harvest product from the waste materials produced in a bioreactor.
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公开(公告)号：US20170159005A1
公开(公告)日：2017-06-08
申请号：US15432737
申请日：2017-02-14
Applicant: FloDesign Sonics, Inc.
Inventor： Bart Lipkens , Louis Masi , Stanley Kowalski, III , Walter M. Presz, JR. , Jason Dionne , Brian Dutra , Ari Mercado , Thomas J. Kennedy, III , Arthur Martin
CPC classification number: C12M47/02 , B01D17/04 , B01D17/06 , B01D21/283 , B01J19/10 , B01J19/18 , B06B1/0644 , C02F1/36 , C02F3/00 , C12M23/14 , C12M23/22 , C12M27/02 , C12M29/10 , C12M29/18 , C12M33/08 , C12M33/14 , C12M35/04 , C12M47/10
Abstract: A perfusion bioreactor includes at least one ultrasonic transducer that can acoustically generate a multi-dimensional standing wave. The standing wave can be used to retain cells in the bioreactor, and can also be utilized to dewater or further harvest product from the waste materials produced in a bioreactor.
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