公开(公告)号：US07021122B1

公开(公告)日：2006-04-04

申请号：US09646348

申请日：1999-03-18

Applicant: Yossef Rosemberg ,  Falk Fish ,  Raphael Levi

Inventor： Yossef Rosemberg ,  Falk Fish ,  Raphael Levi

IPC: G01N11/00

CPC classification number: G01N33/491 ,  G01N11/04 ,  G01N2011/0066

Abstract: A sensor device (10) and a method for measuring a viscosity of a sample of a liquid. The sensor features a chamber (12) for receiving the sample of the liquid, two electrodes (18) disposed either on the surfaces of the chamber, but possibly isolated from contacting the sample, or electrodes located externally to the chamber, and a capacitance measuring circuit (25). The sensor is used by connecting to a measurer for determining a capacitance on the electrodes, such that the capacitance directly reflects a volume occupied by the sample of the liquid. Preferably, the liquid is blood and the capacitance is used to determine the clotting time of the blood. Also preferably, a cover for the chamber is provided with at least one aperture, which more preferably is a mesh. Alternatively, an electrical property such as the amplitude of current passed through the sample is used to determine clotting time. Also preferably, the time period required for the maximum capacitance to be reached could be measured. Alternatively, the capacitance could be measured after a fixed time period (34) had elapsed. Also alternatively, the time period required for the maximum current to be reached could be measured, or the amount of current could be measured after a fixed time period had elapsed. In preferred embodiments of the present invention, a kit for measuring the clotting time of blood is provided. In other preferred embodiments of the present invention, methods are provided for using the kit and device of the present invention.

Abstract translation: 传感器装置（10）和用于测量液体样品的粘度的方法。 传感器具有用于接收液体样品的腔室（12），设置在腔室表面上但可能与接触样品或位于腔室外部的电极隔离的两个电极（18）和电容测量 电路（25）。 传感器通过连接到用于确定电极上的电容的测量器来使用，使得电容直接反映由液体样品占据的体积。 优选地，液体是血液，并且电容用于确定血液的凝血时间。 还优选地，用于腔室的盖设置有至少一个孔，更优选地是网。 或者，使用诸如通过样品的电流的振幅的电特性来确定凝固时间。 还优选地，可以测量达到最大电容所需的时间。 或者，可以在经过固定时间段（34）之后测量电容。 或者，可以测量达到最大电流所需的时间段，或者在固定时间段过去之后可以测量电流量。 在本发明的优选实施方案中，提供了用于测量血液凝血时间的试剂盒。 在本发明的其它优选实施方案中，提供了使用本发明的试剂盒和装置的方法。

公开(公告)号：US4549011A

公开(公告)日：1985-10-22

申请号：US533770

申请日：1983-09-19

Applicant: Max Herzberg ,  Falk Fish

Inventor： Max Herzberg ,  Falk Fish

IPC: G01N33/547 ,  A61F13/00 ,  A61K39/00 ,  B01D15/08 ,  B01D71/10 ,  B01J20/28 ,  C08L1/02 ,  C12Q1/00 ,  G01N33/543 ,  G01N33/558

CPC classification number: B01D71/10 ,  B01D15/3804 ,  B01D61/00 ,  B01D67/0093 ,  B01J20/28033 ,  G01N33/54353 ,  G01N33/558 ,  B01D2311/2626

Abstract: A sheet for separating and retaining biological molecules. The sheet is activated with a compound for covalently binding a ligand to said sheet, and then coated with ligands having an affinity for the substance of interest. A method of using the sheet for isolating and separating substances of interest and methods for forming the sheet.

Abstract translation: 用于分离和保留生物分子的片材。 该片用化合物活化，用于将配体共价结合到所述片材上，然后用对目标物质具有亲和性的配体包被。 用于分离和分离感兴趣物质的片材的方法和用于形成片材的方法。

公开(公告)号：US20110129396A1

公开(公告)日：2011-06-02

申请号：US12790828

申请日：2010-05-30

Applicant: Falk Fish

Inventor： Falk Fish

IPC: B01L3/02

CPC classification number: B01L3/022 ,  B01L2200/0684 ,  B01L2300/123 ,  B01L2400/0481

Abstract: A volumetric micropipette for sampling and dispensing a precise quantity of liquid comprising an elongated hollow tubular body configured to draw liquid by capillary action: a reservoir connected proximate the upper end of the tubular body and a deformable hollow bulb connected to the reservoir and having an opening in a wall thereof to allow liquid to be drawn into the tubular body by capillary action. The reservoir is laterally offset with respect to the tubular body and has at least a portion thereof below the upper end of the tubular body.

Abstract translation: 一种用于取样和分配精确量的液体的体积微量移液器，其包括细长的中空管状体，其构造成通过毛细管作用来拉伸液体：靠近管状体的上端连接的储存器和连接到储存器的可变形的中空球， 在其壁中以允许液体通过毛细管作用被吸入管状体。 储存器相对于管状体侧向偏移，并且其至少一部分在管状体的上端下方。

公开(公告)号：US07004901B2

公开(公告)日：2006-02-28

申请号：US10381704

申请日：2001-09-06

Applicant: Falk Fish

Inventor： Falk Fish

IPC: A61B5/00 ,  G01N33/66

CPC classification number: G01N33/66 ,  Y10T436/144444

Abstract: A method is provided for determining the level of an analyte in the blood of an individual by measuring the level of the analyte in an interstitial fluid or in any other non blood fluid which does not contain red blood cells and adjusting the measurement value by the concentration of at least one reference analyte.

Abstract translation: 提供了一种用于通过测量间质液中的分析物的水平或不含红细胞的任何其它非血液中的分析物的水平并通过浓度调节测量值来确定个体血液中分析物的水平的方法 的至少一种参考分析物。

公开(公告)号：US20050084879A1

公开(公告)日：2005-04-21

申请号：US10885688

申请日：2004-07-08

Applicant: Gennady Rott ,  Fred Samuels ,  Falk Fish

Inventor： Gennady Rott ,  Fred Samuels ,  Falk Fish

IPC: C12Q1/68 ,  G01N33/543 ,  G01N33/80

CPC classification number: G01N33/80

Abstract: A method for the detection and/or visualization of particle agglutination, comprising: placing a volume of a suspension of the particles on a filter, the filter being constructed so as to permit passage of individual particles; placing a volume of a solution or suspension containing an agglutinating agent at the location of the particle suspension; optionally placing a wash solution at the location of the agglutinating agent; and observing the surface at the location for the presence of particles, such presence indicating that agglutination of the particles occurred. There is also provided a method for detection of agglutination reactions in general and hemagglutination reactions, such as used in blood grouping and cross-matching, in particular. The method is comprised of successive vertical additions of whole blood, blood grouping reagent and wash to a filter. In case of hemagglutination a colored, preferably red or reddish dot becomes visible after washing. A device and a kit based on the invention is also claimed and facilitates blood grouping and matching in non-laboratory environment without the need for laboratory instruments.

Abstract translation: 一种用于检测和/或可视化颗粒凝集的方法，包括：将一定体积的所述颗粒的悬浮液放置在过滤器上，所述过滤器被构造成允许单个颗粒通过; 将一定体积的含有凝集剂的溶液或悬浮液放置在颗粒悬浮液的位置; 任选地将洗涤溶液置于凝集剂的位置; 并且在该位置处观察颗粒存在的表面，这种存在表明颗粒的凝集发生。 还提供了一般检测凝集反应的方法，特别是用于血液分组和交叉匹配的血细胞凝集反应。 该方法由连续垂直添加全血，血液分组试剂和洗涤组成。 在血细胞凝集的情况下，洗涤后可见有色的，优选的红色或微红色点。 还要求一种基于本发明的装置和试剂盒，并且便于非实验室环境中的血液分组和匹配，而不需要实验室仪器。

公开(公告)号：US5389338A

公开(公告)日：1995-02-14

申请号：US101965

申请日：1993-08-04

Applicant: Falk Fish

Inventor： Falk Fish

IPC: G01N33/52 ,  G01N33/543 ,  G01N33/00 ,  G01N21/00

CPC classification number: G01N33/54366 ,  G01N33/528

Abstract: Apparatus for dry chemical analysis of fluids comprising a filter, a filter holder apparatus including a base member defining a filter supporting location and a filter retaining apparatus including a mesh arranged to retain the filter at the filter supporting location in spaced relationship with respect to the mesh.

Abstract translation: 用于包括过滤器的流体的干式化学分析的设备，包括限定过滤器支撑位置的基底构件的过滤器保持器装置和包括网格的过滤器保持装置，所述过滤器保持装置被布置成将过滤器保持在过滤器支撑位置处， 。

公开(公告)号：US5126276A

公开(公告)日：1992-06-30

申请号：US113395

申请日：1987-10-19

Applicant: Falk Fish ,  Max Herzberg ,  Menachem Ritterband

Inventor： Falk Fish ,  Max Herzberg ,  Menachem Ritterband

IPC: A61K39/00 ,  B01L3/00 ,  G01N33/543

CPC classification number: B01L3/5085 ,  G01N33/54366 ,  Y10S435/973 ,  Y10S435/975 ,  Y10S436/807 ,  Y10S436/808 ,  Y10S436/809 ,  Y10S436/81 ,  Y10S436/82

Abstract: A solid phase immuno-assay system for assaying at least one analyte, in the form of a solid support having a plurality of receptors bound thereto. At least two of the receptors conjugate with the same analyte.A reaction container comprising a plurality of longitudinally arranged individual compartments, and a longitudinally extending single compartment.A card for assaying a plurality of samples for the same analyte, having a plurality of receptors for the analyte at different locations on the card.A method of performing an assay for the same analyte in more than one sample, by providing a receptor for the analyte at more than a single location on a solid substrate; exposing each of the receptors to different samples; and developing each of the receptor locations to indicate the presence of the analyte in each of the samples.

Abstract translation: 一种用于测定至少一种分析物的固相免疫测定系统，其具有结合有多个受体的固体支持物的形式。 至少两个受体与相同的分析物共轭。 反应容器，其包括多个纵向排列的单个隔室，以及纵向延伸的单个隔室。 用于分析相同分析物的多个样品的卡，其具有用于在卡上不同位置处的分析物的多个受体。 通过在固体基质上超过单个位置提供分析物的受体来对多于一个样品进行相同分析物的测定的方法; 将每个受体暴露于不同的样品; 并开发每个受体位置以指示每个样品中分析物的存在。