公开(公告)号：ZA9209826B

公开(公告)日：1993-09-08

申请号：ZA929826

申请日：1992-12-18

Applicant: GLAXO INC

Inventor： FRYE STEPHEN VERNON ,  CRIBBS CYNTHIA MARKET ,  MALONEY PATRICK REED ,  ANDREWS ROBERT CARL ,  HAFFNER CURT DALE

IPC: A61K20060101 ,  C07J20060101 ,  C07J ,  A61K

公开(公告)号：MX9308015A

公开(公告)日：1994-08-31

申请号：MX9308015

申请日：1993-12-15

Applicant: GLAXO INC

Inventor： HAFFNER CURT DALE ,  MALONEY PATRICK REED ,  ANDREWS ROBERT CARL ,  CRIBBS CYNTHIA MARKERT ,  FRYE STEPHEN VERNON

IPC: A61K31/58 ,  A61K20060101 ,  A61P37/08 ,  C07C20060101 ,  C07C211/41 ,  C07C211/45 ,  C07D309/14 ,  C07D317/58 ,  C07D335/02 ,  C07J20060101 ,  C07J3/00 ,  C07J63/00 ,  C07J73/00 ,  C07J75/00 ,  C07C49/603

公开(公告)号：CA2152053A1

公开(公告)日：1994-07-07

申请号：CA2152053

申请日：1993-12-17

Applicant: GLAXO INC

Inventor： ANDREWS ROBERT CARL ,  CRIBBS CYNTHIA MARKERT ,  FRYE STEPHEN VERNON ,  HAFFNER CURT DALE ,  MALONEY PATRICK REED

IPC: A61K31/58 ,  A61K20060101 ,  A61P37/08 ,  C07C20060101 ,  C07C211/41 ,  C07C211/45 ,  C07D309/14 ,  C07D317/58 ,  C07D335/02 ,  C07J20060101 ,  C07J3/00 ,  C07J63/00 ,  C07J73/00 ,  C07J75/00 ,  C07C211/40 ,  C07C211/52

Abstract: The present invention relates to certain substituted 17.beta.-substituted carbonyl-6-azaandrost-4-en-3-ones of formula (I). wherein R1 and R2 i) are independently hydrogen or lower alkyl and the bond between the carbons bearing R1 and R2 is a single or a double bond, or ii) taken together are a -CH2- group forming a cyclopropane ring, and the bond between the carbons bearing R1 and R2 is a single bond; R3 is preferably hydrogen, halogen or lower alkyl, R4 is preferably hydrogen or lower alkyl, X is preferably CH2, Y is preferably hydrogen and Z is preferably CONR14R15 and R14 and R15 are a variety of organic groups, and pharmaceutically acceptable salts thereof, preparation, medical use and pharmaceutical formulations.