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公开(公告)号：US20210088446A1
公开(公告)日：2021-03-25
申请号：US16629202
申请日：2018-04-18
Applicant: HAMAMATSU PHOTONICS K.K.
Inventor： Norikazu SUGIYAMA , Masanori MATSUBARA , Satoshi YAMAMOTO
Abstract: A sample observation device includes an irradiation unit that irradiates a sample with planar light, a scanning unit that scans the sample in one direction with respect to an irradiation surface of the planar light, an image formation unit that forms images of fluorescent light and scattered light from the sample, an imaging unit that outputs first image data based on a light image of the fluorescent light and second image data based on a light image of the scattered light, an image processing unit that generates a fluorescent light image on the basis of a plurality of pieces of first image data and generates a scattered light image on the basis of a plurality of pieces of second image data, and an analysis unit that specifies an area in which there is the sample in the fluorescent light image on the basis of the scattered light image, and sets an analysis area in the fluorescent light image on the basis of the area in which there is the sample.
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公开(公告)号：US20200158633A1
公开(公告)日：2020-05-21
申请号：US16631927
申请日：2018-05-30
Applicant: HAMAMATSU PHOTONICS K.K.
Inventor： Satoshi YAMAMOTO , Masanori MATSUBARA , Norikazu SUGIYAMA , Masanori KOBAYASHI
Abstract: A sample observation device includes a flow cell in which a fluid containing samples flows, an irradiation unit configured to irradiate the samples flowing in the flow cell with planar light, an image formation unit having an observation axis inclined with respect to an irradiation surface for the planar light, and configured to form an image of observation light generated in the sample due to the irradiation with the planar light, a two-dimensional imaging element configured to capture a light image including at least a cross section of the fluid among light images according to the observation light formed by the image formation unit, and outputs image data, and an analysis unit configured to analyze a light intensity profile of the sample in a flow direction of the fluid on the basis of the image data.
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公开(公告)号：US20200041776A1
公开(公告)日：2020-02-06
申请号：US16340797
申请日：2017-08-15
Applicant: HAMAMATSU PHOTONICS K.K.
Inventor： Satoshi YAMAMOTO , Masanori MATSUBARA , Norikazu SUGIYAMA
Abstract: A sample observation device (1) includes: an emission optical system (3) for emitting planar light (L2) onto a sample (S); a scanning unit (4) for scanning the sample (S) with respect to an emission face (R) of the planar light (L2); an imaging optical system (5) having an observation axis (P2) inclined with respect to the emission face (R) and for forming an image from observation light (L3) generated in the sample (S) in accordance with the emission of the planar light (L2); an image acquiring unit (6) for acquiring a plurality of partial image data corresponding to a part of an optical image according to the observation light (L3) formed as an image by the imaging optical system (5); and an image generating unit (8) for generating observation image data of the sample S based on the plurality of partial image data generated by the image acquiring unit (6).
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公开(公告)号：US20230222753A1
公开(公告)日：2023-07-13
申请号：US17928992
申请日：2021-06-14
Applicant: HAMAMATSU PHOTONICS K.K.
Inventor： Satoshi YAMAMOTO , Masanori MATSUBARA
IPC: G06V10/143 , G06T7/70 , G06V10/28 , G06V10/60
CPC classification number: G06V10/143 , G06T7/70 , G06V10/28 , G06V10/60 , G06T2207/10152
Abstract: In a sample observation device, an image acquisition unit 6 acquires a plurality of pieces of image data of a sample in a Y-axis direction, and an image generation unit generates luminance image data on luminance of the sample on the basis of the plurality of pieces of image data, binarizes luminance values of each of the plurality of pieces of image data to generate a plurality of pieces of binarized image data, and generates area image data on an existing area of the sample on the basis of the plurality of pieces of binarized image data.
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公开(公告)号：US20230184681A1
公开(公告)日：2023-06-15
申请号：US17925131
申请日：2021-03-17
Applicant: HAMAMATSU PHOTONICS K.K.
Inventor： Satoshi YAMAMOTO
IPC: G01N21/64
CPC classification number: G01N21/6456 , G01N21/6452 , G01N2201/103 , G02B21/06
Abstract: In this sample observation device, a reference table in which an optimum light amount of planar light at a measurement sensitivity represented by the product of a light amount of the planar light and a scanning speed is set according to the scanning speed is referred to, and the scanning speed of a scanning unit and the optimum light amount of the planar light that is applied to a sample are determined on the basis of the measurement sensitivity selected by a user.
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Patent Agency Ranking
公开(公告)号：US20230176352A1
公开(公告)日：2023-06-08
申请号：US17924160
申请日：2021-03-17
Applicant: HAMAMATSU PHOTONICS K.K.
Inventor： Masanori KOBAYASHI , Satoshi YAMAMOTO
CPC classification number: G02B21/0032 , G01N21/6456 , G01N2201/06113
Abstract: A light irradiation device includes: a light source configured to output light having coherence; a light focusing element having a focusing axis and a non-focusing axis intersecting with the focusing axis and configured to focus the light on a focusing line so as to generate planar light; and an aperture mask having an opening part that limits a part of luminous fluxes of the light transmitted from the light source to the light focusing element. The opening part of the aperture mask has opening edges disposed to extend in a direction along the focusing axis of the light focusing element, and, in a case in which the opening edges are projected onto the focusing line, corresponding projected portions have linear spreads.
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公开(公告)号：US20210382286A1
公开(公告)日：2021-12-09
申请号：US17411533
申请日：2021-08-25
Applicant: HAMAMATSU PHOTONICS K.K.
Inventor： Satoshi YAMAMOTO , Masanori MATSUBARA , Norikazu SUGIYAMA
Abstract: A sample observation device (1) includes: an emission optical system (3) for emitting planar light (L2) onto a sample (S); a scanning unit (4) for scanning the sample (S) with respect to an emission face (R) of the planar light (L2); an imaging optical system (5) having an observation axis (P2) inclined with respect to the emission face (R) and for forming an image from observation light (L3) generated in the sample (S) in accordance with the emission of the planar light (L2); an image acquiring unit (6) for acquiring a plurality of partial image data corresponding to a part of an optical image according to the observation light (L3) formed as an image by the imaging optical system (5); and an image generating unit (8) for generating observation image data of the sample S based on the plurality of partial image data generated by the image acquiring unit (6).
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18.发明申请公开(公告)号：US20150369790A1
公开(公告)日：2015-12-24
申请号：US14766238
申请日：2014-02-05
Applicant: HAMAMATSU PHOTONICS K.K.
Inventor： Hidenao IWAI , Takuji KATAOKA , Satoshi YAMAMOTO , Norikazu SUGIYAMA , Toyohiko YAMAUCHI , Kentaro GOTO
IPC: G01N33/483 , G01N21/47
CPC classification number: G01N33/4833 , G01B11/00 , G01N21/47 , G01N21/49 , G01N2021/4707 , G01N2021/479
Abstract: An aggregated cell evaluation apparatus includes a laser light source, a speckle image acquisition unit, an SC calculation unit, an evaluation unit, and a memory unit. The speckle image acquisition unit acquires a two-dimensional speckle image by forward scattered light generated in aggregated cells by irradiation of the aggregated cells with laser light output from the laser light source. The SC calculation unit calculates a speckle contrast value Kn of a speckle image In at each time tn, determines a maximum value Kmax among the speckle contrast values K1 to KN, and normalizes the speckle contrast value Kn at each time tn by the maximum value Kmax to obtain a normalized speckle contrast value Kn′. The evaluation unit evaluates motion of the aggregated cells, based on the normalized speckle contrast value Kn′ at each time tn.
Abstract translation: 聚合单元评估装置包括激光光源，散斑图像获取单元，SC计算单元，评估单元和存储单元。 斑点图像获取单元通过从激光光源输出的激光照射聚集单元，在聚集单元中产生的前向散射光获取二维散斑图像。 SC计算单元计算每次tn时的散斑图像In的散斑对比度值Kn，确定散斑对比度值K 1〜K N的最大值Kmax，并将每个时间tn处的散斑对比度值Kn标准化最大值Kmax 以获得归一化散斑对比度值Kn'。 评估单元基于每个时刻tn处的归一化散斑对比度值Kn'评估聚集单元的运动。
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公开(公告)号：US20250035901A1
公开(公告)日：2025-01-30
申请号：US18911797
申请日：2024-10-10
Applicant: HAMAMATSU PHOTONICS K.K.
Inventor： Masanori KOBAYASHI , Satoshi YAMAMOTO
Abstract: A light irradiation device includes: a light source configured to output light having coherence; a light focusing element having a focusing axis and a non-focusing axis intersecting with the focusing axis and configured to focus the light on a focusing line so as to generate planar light; and an aperture mask having an opening part that limits a part of luminous fluxes of the light transmitted from the light source to the light focusing element. The opening part of the aperture mask has opening edges disposed to extend in a direction along the focusing axis of the light focusing element, and, in a case in which the opening edges are projected onto the focusing line, corresponding projected portions have linear spreads.
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公开(公告)号：US20240210319A1
公开(公告)日：2024-06-27
申请号：US18382177
申请日：2023-10-20
Applicant: HAMAMATSU PHOTONICS K.K.
Inventor： Satoshi YAMAMOTO
IPC: G01N21/64
CPC classification number: G01N21/6456 , G01N2201/11 , G01N2201/127
Abstract: In a sample observation device, an image capturing unit includes an area image sensor that performs image capturing by the rolling shutter method in which a start of an exposure period of pixel columns in the pixel region is shifted by predetermined time, and a control unit controls the image capturing unit so that an exposure order in each of the pixel columns is reversed between a period in which a scanning unit scans a sample in a first direction and a period in which the scanning unit scans the sample in a second direction.
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