MEDICINAL COMPOSITIONS AND ITS USE AS ANTIDEPRESSIVE AGENT

    公开(公告)号:ZA783123B

    公开(公告)日:1979-06-27

    申请号:ZA783123

    申请日:1978-05-30

    Applicant: HOECHST AG

    Abstract: What is disclosed are medicinal compositions, useful as anti-depressive agents, containing a compound of the formula; (I) in which R1, R3 and R4, which may be identical or different, and represent hydrogen atoms or lower alkyl or aralkyl groups, and R2 and R2', which may be identical or different, represent hydrogen or halogen atoms, hydroxy or trifluoromethyl groups or lower alkyl, alkoxy or aralkoxy groups, it also being possible that two adjacent radicals form an alkylene-dioxy radical, and R5 represents a hydrogen or halogen atom, a hydroxy, trifluoromethyl or nitro group or a lower alkyl, alkoxy or aralkoxy radical, and their salts with acids (active substance A) together with 7-chloro-1-methyl-5-phenyl-1H-1,5-benzodiazepine-2,4 (3H,5H)-dione (active substance B), and their use as antidepressive agent.

    ORALLY ADMINISTRABLE DRUG DOSAGE FORM HAVING DELAYED ACTION

    公开(公告)号:ZA711412B

    公开(公告)日:1971-11-24

    申请号:ZA711412

    申请日:1971-03-04

    Applicant: HOECHST AG

    Abstract: Process for the manufacture of an orally administrable, delayed-action drug dosage form having the form of small globules which are provided with a release-delaying coating, wherein the active substance is applied onto small inert, essentially round globules, the globules so coated are provided with a release-delaying coating which is suitable as dialysis membrane and which contains as film former polyvinyl acetate, preferably in admixture with ethyl cellulose, and filling the globules so obtained in dosage units.

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