公开(公告)号：AR192762A1

公开(公告)日：1973-03-14

申请号：AR24144572

申请日：1972-04-13

Applicant: HOECHST AG

Inventor： KUCH H ,  HOFFMANN I

IPC: C07D243/12 ,  C07F9/53 ,  C07F9/645

Abstract: Dialkylphosphinylalkylene-substituted 1,5-benzodiazepines useful as medicaments in the treatment of psychic diseases are obtainable by reacting the corresponding benzodiazepines with a dialkyl-phosphinylalkyl halide or by reacting a 2-dialkyl-phosphinylalkylaminodiphenylamine with a malonic acid dihalide or alkylmalonic acid dihalide.

公开(公告)号：ZA7202518B

公开(公告)日：1973-01-31

申请号：ZA7202518

申请日：1972-04-14

Applicant: HOECHST AG

Inventor： KUCH H ,  HOFFMANN I

IPC: C07D243/12 ,  C07F9/53 ,  C07F9/645 ,  C07D

CPC classification number: C07F9/645 ,  C07F9/5304

公开(公告)号：SE329620B

公开(公告)日：1970-10-19

申请号：SE1601767

申请日：1967-11-22

Applicant: HOECHST AG

Inventor： KUCH H ,  SCHMITT K ,  SEIDL G ,  HOFFMANN I

IPC: C07D265/18 ,  C07D87/20

Abstract: 2-Amino-4,4-di-substituted benzoxazine derivatives and the salts thereof with a physiologically compatible acid have an action on the central nervous system. These benzoxazines have the formula IN WHICH R is hydrogen, alkyl of one to four carbon atoms, cyclohexyl, phenyl or benzyl, R1 is hydrogen, halogen, trifluoromethyl, R2 is alkyl of one to four carbon atoms and R3 is phenyl or halophenyl.

公开(公告)号：NO119681B

公开(公告)日：1970-06-22

申请号：NO16327566

申请日：1966-06-02

Applicant: HOECHST AG

Inventor： KUCH H ,  SEIDL G ,  HOFFMANN I

IPC: B02C18/06 ,  C07D219/02 ,  C07D219/04 ,  C07D219/06 ,  C07D219/14 ,  C07D265/18 ,  C07D265/38

Abstract: (A) 3,1-Benzothiazines and 3,1-benzoxazines of gen. formula (I), where A = O or S R = H, alkyl, cycloalkyl, alkenyl, cycloalkenyl aryl, aralkyl, or lower dialkylaminoalkyl in which the dialkylamino group can also be cyclized via O, S, or methyl- or benzylimino, R1 = H, halogen, methoxy, CF3, NO2 R2 = alkyl, aralkyl, or aryl, in which the benzene rings of the last two can be substituted by halogen, methoxy, CF3, NO2. (B) Salts of I formed with organic and inorganic acids. Compounds (1) combine valuable pharmacological properties with very low toxicity. They are central depressants, as well as stimulants, sedatives, noradrenaline potentiators, analgesics and spasmolytics, and they prolong narcosis. They are useful in the treatment of mental diseases, e.g. depression, psychioneuroses, disturbances and anxiety states of neurotic and psychotic patients.

公开(公告)号：DK162682A

公开(公告)日：1982-10-10

申请号：DK162682

申请日：1982-04-07

Applicant: HOECHST AG

Inventor： KUCH H ,  KRUSE H

IPC: A61K31/40 ,  A61K31/403 ,  A61K31/404 ,  A61P25/28 ,  C07D209/34 ,  C07D209/36 ,  C07D209/38 ,  C07D295/185 ,  C07D

Abstract: Oxindole derivatives of the general formula I (I) are described, and also processes for their preparation and drugs containing them. The new compounds exhibit a neuroanabolic action in various animal models.

公开(公告)号：CH572066A5

公开(公告)日：1976-01-30

申请号：CH1345375

申请日：1972-04-12

Applicant: HOECHST AG

Inventor： KUCH H ,  HOFFMANN I

IPC: C07D243/12 ,  C07F9/53 ,  C07F9/645

Abstract: Dialkylphosphinylalkylene-substituted 1,5-benzodiazepines useful as medicaments in the treatment of psychic diseases are obtainable by reacting the corresponding benzodiazepines with a dialkyl-phosphinylalkyl halide or by reacting a 2-dialkyl-phosphinylalkylaminodiphenylamine with a malonic acid dihalide or alkylmalonic acid dihalide.

公开(公告)号：CH570414A5

公开(公告)日：1975-12-15

申请号：CH535772

申请日：1972-04-12

Applicant: HOECHST AG

Inventor： KUCH H ,  HOFFMANN I

IPC: C07D243/12 ,  C07F9/53 ,  C07F9/645

Abstract: Dialkylphosphinylalkylene-substituted 1,5-benzodiazepines useful as medicaments in the treatment of psychic diseases are obtainable by reacting the corresponding benzodiazepines with a dialkyl-phosphinylalkyl halide or by reacting a 2-dialkyl-phosphinylalkylaminodiphenylamine with a malonic acid dihalide or alkylmalonic acid dihalide.

公开(公告)号：FI48595B

公开(公告)日：1974-07-31

申请号：FI316967

申请日：1967-11-24

Applicant: HOECHST AG

Inventor： KUCH H ,  SCHMITT K ,  SEIDL G ,  HOFFMANN I

IPC: C07D265/18 ,  C07D87/20

Abstract: 2-Amino-4,4-di-substituted benzoxazine derivatives and the salts thereof with a physiologically compatible acid have an action on the central nervous system. These benzoxazines have the formula IN WHICH R is hydrogen, alkyl of one to four carbon atoms, cyclohexyl, phenyl or benzyl, R1 is hydrogen, halogen, trifluoromethyl, R2 is alkyl of one to four carbon atoms and R3 is phenyl or halophenyl.

公开(公告)号：ZA722518B

公开(公告)日：1973-01-31

申请号：ZA722518

申请日：1972-04-14

Applicant: HOECHST AG

Inventor： KUCH H ,  HOFFMANN I

IPC: C07F9/53 ,  C07D243/12 ,  C07F9/645 ,  C07D

Abstract: Dialkylphosphinylalkylene-substituted 1,5-benzodiazepines useful as medicaments in the treatment of psychic diseases are obtainable by reacting the corresponding benzodiazepines with a dialkyl-phosphinylalkyl halide or by reacting a 2-dialkyl-phosphinylalkylaminodiphenylamine with a malonic acid dihalide or alkylmalonic acid dihalide.

公开(公告)号：FR2133751A1

公开(公告)日：1972-12-01

申请号：FR7213212

申请日：1972-04-14

Applicant: HOECHST AG

Inventor： KUCH H ,  HOFFMANN I

IPC: C07F9/53 ,  C07F9/645 ,  C07D243/12 ,  A61K27/00 ,  C07F9/00

Abstract: Dialkylphosphinylalkylene-substituted 1,5-benzodiazepines useful as medicaments in the treatment of psychic diseases are obtainable by reacting the corresponding benzodiazepines with a dialkyl-phosphinylalkyl halide or by reacting a 2-dialkyl-phosphinylalkylaminodiphenylamine with a malonic acid dihalide or alkylmalonic acid dihalide.