公开(公告)号：US3761464A

公开(公告)日：1973-09-25

申请号：US3761464D

申请日：1971-01-25

Applicant: HOECHST AG

Inventor： RADSCHEIT K ,  HAEDE W ,  LINDNER E ,  STACHE U ,  FRITSCH W

IPC: A61K31/585 ,  C07D20060101 ,  C07J19/00 ,  C07C173/00

Abstract: CARDIO-ACTIVE PYRANOSIDES OF 3B-HYDROXY-4-CHLORO-CARDA-4,20(22)-DIENOLIDES AND PROCESS FOR THEIR MANUFACTURE BY REACTING CORRESPONDING 3B-HYDROXY STEROIDS WITH ACYLATED-1-HALOGENO-PYRANOSES IN THE PRESENCE OF SILVER CARBONATE.

公开(公告)号：US3741955A

公开(公告)日：1973-06-26

申请号：US3741955D

申请日：1971-04-06

Applicant: HOECHST AG

Inventor： FRITSCH W ,  HAEDE W ,  RADSCHEIT K ,  STACHE U ,  LINDNER E

IPC: A61K31/70 ,  C07J71/00 ,  C07C173/00

CPC classification number: A61K31/70 ,  C07J71/00

Abstract: CARDIOACTIVE 3B - HYDROXY-14,15B-OXIDO-14B-BUFA-4,20, 22-TRIENOLIDE-3B-(A-L-RHAMNOPYRANOSIDE). METHOD OF MAKING THIS COMPOUND BY ACYLATING AND DEHYDRATING PROSCILLARDIN, FORMING A HALOHYDRIN FROM THE RESULTING $14-OLEFIN, DEHYDROGALOGENATING TO FORM THE 14,15B-EPOXIDE, AND HYDROLYZING TO FORM THE FREE LRHAMNOPYRANOSIDE.

公开(公告)号：US3725393A

公开(公告)日：1973-04-03

申请号：US3725393D

申请日：1971-10-18

Applicant: HOECHST AG

Inventor： STACHE U ,  FRITSCH W ,  HAEDE W ,  RADSCHEIT K ,  LINDNER E

IPC: A61K20060101 ,  C07D20060101 ,  C07J19/00 ,  C07C173/02

CPC classification number: C07J75/00

Abstract: 3-N-alkyl-amino-cardenolides of the general formula

Abstract translation: 其中R 1表示氢或β-羟基的通式的3-N-烷基 - 氨基 - 己烯酸烯; R 2和R 3各自表示氢或羟基，或者R 2和R 3一起代表另外的C-C键或α或β-氧代基; R4，R5，R6和R7各自表示氢或可被酯化的羟基 - R6的OH-基团也可以醚化 - ; R8代表氢或羟基; 并且R 9表示可以含有一个或多个OH-基团的碳原子数1〜6的烷基或芳脂肪族基团，及其与无机酸或有机酸的盐。 这些化合物具有有价值的药理学性质，特别是正或负性肌力作用，并且在脂质中具有显着改善的溶解性。

公开(公告)号：DK225382A

公开(公告)日：1982-11-20

申请号：DK225382

申请日：1982-05-18

Applicant: HOECHST AG

Inventor： LESSENICH H ,  KUNSTMANN R ,  LINDNER E

IPC: C07D409/12 ,  A61K20060101 ,  A61K31/38 ,  A61K31/40 ,  A61K31/4433 ,  A61K31/445 ,  A61P9/08 ,  A61P9/10 ,  C07D20060101 ,  C07D

Abstract: Racemic and optically active substituted tryptamine derivatives of thienyloxypropanolamines of the general formula I and their salts, process for the preparation of these compounds, their use in the treatment of cardiovascular diseases, and pharmaceutical compositions containing these compounds.

公开(公告)号：AU511704B2

公开(公告)日：1980-09-04

申请号：AU2543477

申请日：1977-05-24

Applicant: HOECHST AG

Inventor： FRITSCH W ,  STACHE U ,  LINDNER E

IPC: C07D295/08 ,  A61K31/13 ,  A61K31/135 ,  A61K31/19 ,  A61K31/215 ,  A61K31/275 ,  A61K31/34 ,  A61K31/357 ,  A61K31/435 ,  A61K31/495 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12 ,  C07C67/00 ,  C07C213/00 ,  C07C217/32 ,  C07C253/00 ,  C07C255/37 ,  C07D211/14 ,  C07D211/22 ,  C07D213/36 ,  C07D213/74 ,  C07D241/04 ,  C07D295/092 ,  C07D295/112 ,  C07D317/58 ,  C07C121/80 ,  A61K31/165 ,  A61K31/40 ,  A61K31/44 ,  A61K31/445 ,  A61K31/50 ,  A61K31/535 ,  C07C101/30 ,  C07D295/14 ,  C07D295/18 ,  C07D295/22 ,  C07D401/04

公开(公告)号：PH12212A

公开(公告)日：1978-11-29

申请号：PH12440

申请日：1971-05-10

Applicant: HOECHST AG

Inventor： SCHORR M ,  RUSCHIG H ,  RIPPEL R ,  LINDNER E

IPC: C07C49/30

公开(公告)号：DK227177A

公开(公告)日：1977-11-26

申请号：DK227177

申请日：1977-05-24

Applicant: HOECHST AG

Inventor： FRITSCH W ,  STACHE U ,  LINDNER E

IPC: C07D295/08 ,  A61K31/13 ,  A61K31/135 ,  A61K31/19 ,  A61K31/215 ,  A61K31/275 ,  A61K31/34 ,  A61K31/357 ,  A61K31/435 ,  A61K31/495 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12 ,  C07C67/00 ,  C07C213/00 ,  C07C217/32 ,  C07C253/00 ,  C07C255/37 ,  C07D211/14 ,  C07D211/22 ,  C07D213/36 ,  C07D213/74 ,  C07D241/04 ,  C07D295/092 ,  C07D295/112 ,  C07D317/58 ,  C07C

公开(公告)号：SE390107B

公开(公告)日：1976-12-06

申请号：SE212172

申请日：1972-02-22

Applicant: HOECHST AG

Inventor： GROEBEL A ,  LINDNER E

IPC: A61K20060101 ,  A61K36/00 ,  A61K36/24 ,  C07C20060101 ,  C07G5/00 ,  C07G99/00 ,  A61K35/78

公开(公告)号：SE7502213L

公开(公告)日：1975-09-03

申请号：SE7502213

申请日：1975-02-27

Applicant: HOECHST AG

Inventor： STACHE U ,  FRITSCH W ,  HAEDE W ,  LINDNER E

IPC: C07J19/00 ,  C07J17/00

Abstract: 1499908 12-Dehydrodigoxin ethers HOECHST AG 28 Feb 1975 [2 March 1974] 8562/75 Heading C2U The invention comprises the 3 111 - and 4 111 - (C 1-4 alkyl) monoethers of 12-dehydrodigoxin, and their preparation (i) by oxidizing the corresponding digoxin ethers (e.g. with CrO 3 ), and (ii) by reacting 12-dehydrodigoxin with dialkyl sulphate/DMF/Ba(OH) 2 in the presence of aluminium oxide (to obtain 4 111 -ethers) or of aluminium isopropylate (to obtain 3 111 -ethers), 12-Dehydrodigoxin is prepared by CrO 3 / AcOH oxidation of digoxin. Cardiotonic and diuretic compositions for oral and parenteral administration comprise a carrier and an inventive compound. Reference has been directed by the Comptroller to Specification 1,168,970.

公开(公告)号：DK131573B

公开(公告)日：1975-08-04

申请号：DK416173

申请日：1973-07-27

Applicant: HOECHST AG

Inventor： FRITSCH W ,  HAEDE W ,  LINDNER E ,  STACHE U

IPC: C07J19/00 ,  A61K20060101 ,  A61K31/585 ,  A61K31/704 ,  A61P7/10 ,  A61P9/04 ,  C07C20060101 ,  C07D20060101

Abstract: The invention relates to 3', 4'-anhydro- beta , L-talomethylosides of the general formula I wherein R1 is methyl or formyl and R2 stands for beta -H or beta -OH, if there is no double bond in 4,5-position, and R3 is a butenolide or cumalin ring, a process for preparing them and their use in the treatment of cardiac and circulatory disturbances. The compounds are especially suitable for treating cardiac insufficiency, tachycardia and conduction defects.