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    11.
    发明专利
    未知

    公开(公告)号：SE330170B

    公开(公告)日：1970-11-09

    申请号：SE626567

    申请日：1967-05-03

    Applicant: HOECHST AG

    Inventor： EHRHART G ,  SCHMITT K ,  HOFFMAN I ,  OTT H

    IPC: C07D217/02 ,  C07D217/04 ,  C07D217/14 ,  C07D217/16 ,  C07D35/10

    Abstract: 1,164,192. 4-Phenyl-tetrahydroquinoline derivatives. FARBWERKE HOECHST A.G. 5 May, 1967 [5 May, 1966; 12 Aug., 1966; 15 April, 1967 (2)], No. 21016/67. Heading C2C. Novel compounds of the Formula (I) wherein R is H or alkyl, R 1 is H, acyl of a saturated or unsaturated C 2-6 aliphatic, aromatic or araliphatic carboxylic acid, C 1-5 alkyl, C 7-10 aralkyl; R 2 and R 2 1 may be the same or different and each represent H, halogen, OH, CF 3 , C 1-5 alkyl or alkoxy, C 7-10 aralkoxy, or R 2 and R 2 1 together represent C 1-2 alkylenedioxy; R 3 and R 4 are identical or different and represent H, C 1-5 alkyl, phenyl, or C 7-10 aralkyl, and R 5 is H, halogen, OH, CF 3 , NO 2 , C 1-4 alkyl or alkoxy, or C 7-10 aralkoxy; or a salt thereof, are obtained by (a) effecting ring closure in a compound of the Formula (II) where X is -CHOH, optionally esterified by a sulphonic or carboxylic acid, or a CH-halogen group, by treating it with an acid condensing agent, or (b) treating a compound of the Formula I above (but where R 1 is H and R 4 is not H) with an agent for introducing the acyl radical of a saturated or unsaturated aliphatic carboxylic acid of up to 6 carbon atoms, an aromatic or araliphatic carboxylic acid, or (c) reducing by means of a complex metal hydride, a compound of general Formula IV in which R, R 1 , R 2 , R 2 1, R 4 and R 5 have the meanings given above and R 4 may also represent hydrogen, and, if desired, treating with an alkylating agent a compound of the general Formula I, in which R 1 and/or R 4 represent a hydrogen atom, or by separating in known manner benzyl radicals from a compound of the general Formula I, in which the R 1 and/or R 4 represents benzyl radicals, and/or treating with an ether splitting agent a compound of the general Formula I, in which R 2 , R 2 1 and/or R 5 represent alkoxy or aralkoxy groups, and, if desired, converting the salt obtained into the free base or converting the free base obtained into a physiologically tolerable salt by a treatment with an acid. The following intermediates are also described:- (a) N - (2 - Amino - benzyl) - 1 - phenyl - 2 - methylamino-propanol- (1) is obtained (1) by reducing N - (2 - aminobenzyl) - 2 - methylamino-propiophenone with NaBH 4 , or (ii) by reacting 2-nitrobenzyl chloride with 1-phenyl-2- methylamino-propanol-(1) to yield N-(2-nitrobenzyl) - 1 - phenyl - 2 - methylamino - propanol - (1) and reducing the nitro group with Raney nickel; (b) N - (2 - acetamino - benzyl) - 1 - phenyl - 2 - methylamino - propanol - (1) is obtained by acetylating compound (a) above; (c) 1,2,3,4 - tetrahydro - 2 - methyl - 4 - phenyl - 8-amino -isoquinolone is obtained by condensation of N-methyl-N-(2-aminobenzyl)-mandelic acid amide with H 2 SO 4 ; (d) N - (2 - amino - benzyl) - 1 - (3,4 - dimethylphenyl) - 2 - methylamino - propanol - 1 is obtained by reacting α-bromo-3,4-dimethyl-propiophenone with (2-nitrobenzyl)-methylamine then hydrogenating the NO 2 group and then reducing the CO group; (e) N - (2 - aminobenzyl) - 1 - phenyl - 2 - amino-propanol.(1) is obtained by hydrogenating a mixture of α-acetyl-benzyl alcohol and benzylamine to form 1-phenyl-2-aminopropanol-(1) which is reacted with 2-nitrobenzaldehyde and the product reduced at the nitro and azo-methine groups to form the above compound (e). Pharmaceutical compositions, having a centrally stimulating and thymoleptic action, comprise compounds of Formula I or physiologically tolerable salts thereof, together with a pharmaceutically suitable carrier, in forms suitable for oral or parenteral administration.

    14.
    发明专利
    未知

    公开(公告)号：NO117860B

    公开(公告)日：1969-10-06

    申请号：NO16330466

    申请日：1966-06-04

    Applicant: HOECHST AG

    Inventor： EHRHART G ,  OTT H ,  LINDNER E ,  HAERTFELDER G

    IPC: C07C217/62 ,  C07D213/38

    Abstract: Compounds of the general Formula (I) (wherein R1 represents a phenyl, methoxyphenyl or 2-pyridyl group, R2 represents a hydrogen atom or a methyl group and R3 and R4 each represent a C1- 4 alkyl group) and their acid addition salts are prepared by standard methods, e.g. reducing a compound of the Formula (II) (wherein R represents a hydrogen atom) or a salt thereof, or condensing a compound of the Formula (III) with a compound of the Formula (IV) (wherein X represents and reducing the product, optionally followed in either case by salt formation. The preparation of starting materials of Formulae (II) and (IV) is described. The compounds of the invention are useful in the treatment of hypertonia, and may be administered in the form of pharmaceutical preparations containing them in association with a carrier.

    16.
    发明专利
    未知

    公开(公告)号：FI44617B

    公开(公告)日：1971-08-31

    申请号：FI140566

    申请日：1966-05-27

    Applicant: HOECHST AG

    Inventor： EHRHART G ,  LINDNER E ,  OTT H

    IPC: A61K31/195 ,  C07C101/18

    Abstract: The invention comprises compounds of formula wherein R represents an alkyl radical containing from 1 to 4 carbon atoms, and R1 and R2, which may be the same or different, each represent hydrogen, an alkyl radical containing from 1 to 4 carbon atoms or halogen, and salts thereof. The compounds may be made by (a) reacting with in which R1 represents a hydrogen atom or an alkyl group containing from 1 to 4 carbon atoms and reducing, simultaneously or subsequently, the reaction product, or (b) reacting in the presence of aldehyde of formula (C6H2)2CH-CH2-CHO or (C6H5)2C=CH-CHO and reducing, simultaneously or subsequently, the reaction product and hydrogenating any aliphatic C-C double linkage present, or (c) reacting (C6H5)2CH-CH2-CH2-Hal with wherein Hal represents a halogen atom and R3 represents a hydrogen atom or the benzyl radical, if desired or required in the presence of agents splitting off hydrogen halide, or (d) reacting diphenyl methane or diphenyl acetonitrile with a compound of formula in the presence of agents splitting off hydrogen halide and replacing the nitrile group which may be present in the reaction products by a hydrogen atom by heating with sodium amide in an inert organic solvent, and removing by catalytic hydrogenation the N-benzyl group which may be present, and if compounds of the general Formulae III, IV, VIII, and IX are used, in which R1 represents a hydrogen atom, esterifying the free carboxyl group by reaction with an alcohol containing from 1 to 4 carbon atoms, and, if desired, converting the basic compounds thus obtained into their salts by means of mineral or organic acids. Pharmaceutical compositions, for use in curing cardiac and circulatory disorders, comprise the above compounds, or salts, in admixture with a pharmaceutically suitable carrier. The compositions may be made up in the usual dosage unit forms for oral or parenteral administration, such as tablets, dragees, capsules, ampoules, solutions, emulsions or suspensions.

    17.
    发明专利
    未知

    公开(公告)号：SE321217B

    公开(公告)日：1970-03-02

    申请号：SE754466

    申请日：1966-06-02

    Applicant: HOECHST AG

    Inventor： EHRHART G ,  LINDNER E ,  OTT H

    IPC: A61K31/135 ,  C07C87/02

    Abstract: Novel 1-phenyl-3-aminopropane derivatives of the formula wherein R is hydrogen or methyl and each of R1 and R2 is hydrogen or C1- 4 alkyl, and their physiologically tolerable, acid-addition salts, are prepared by (a) reacting 1-phenyl-1-cyclohexen-(11)-yl-3-aminopropane with a ketone of the formula and simultaneously or subsequently reducing the C-N double bond in the condensation product obtained, or (b) reacting a 1-phenyl-1-cyclohexen - (11) - yl - 3 - aminopropane of the formula with a 1-phenyl-2-halopropane of the formula or (c) reacting a 1-phenyl-1-cyclohexen-(11)-yl-3-halopropane of the formula with a 1-phenyl-2-aminopropane of the formula or (d) reacting 3-phenyl-3-cyclohexen-(11)-yl-propionaldehyde with a 1-phenyl-2-aminopropane of the Formula (VI) wherein R is a hydrogen atom, and simultaneously or subsequently reducing the C-N double linkage in the condensation product obtained, or (e) reacting phenyl-cyclohexylidene-acetonitrile with a 1-phenyl - N - haloethyl - 2 - aminopropane of the formula wherein R1 is methyl, in the presence of an agent capable of binding a hydrohalic acid, and replacing the nitrile group in the compound obtained by a hydrogen atom either by heating the compound with sodium amide in an inert organic solvent or by hydrolysing it with a strong acid and heating the carboxy compound obtained, or (f) reducing a carboxylic acid amide of the formula by means of a complex metal hydride, and, if desired, methylating a compound obtained by any one of the methods (a) to (d) or (f) at the nitrogen atom by reacting it with a methylating agent and/or converting it into an acid addition salt by reaction with an acid. 3 - Phenyl - 3 - cyclohexen - (11) - yl - propionaldehyde is prepared by reacting phenyl-cyclohexylidene-acetonitrile with chloroacetal to form 3 - phenyl - 3 - cyclohexen - (11) - yl - 3-cyanopropionaldehyde-diethylacetal and treating this compound with sodium amide. Pharmaceutical compositions, having an action on the cardiac and vascular blood circulation, for oral or parenteral administration, comprise a compound of the invention together with a carrier.

    18.
    发明专利
    未知

    公开(公告)号：FI40805B

    公开(公告)日：1969-02-28

    申请号：FI72663

    申请日：1963-04-10

    Applicant: HOECHST AG

    Inventor： OTT H ,  EHRHART G ,  LINDNER E

    IPC: C07C69/732 ,  C07C93/20

    Abstract: The invention comprises compounds of the general formula (wherein AC represents a formyl, acetyl or propionyl group) and physiologically tolerable acid addition salts thereof, their preparation by acylating one of the four stereoisomers of 4, 4-diphenyl-6-dimethylaminoheptanol-(3) with a reactive derivative of mandelic acid, the free hydroxy group of which is converted into a formyloxy, acetyloxy or propionyloxy group either before or after the acylation, optionally followed by acid addition salt formation, and pharmaceutical preparations containing them. The compounds of the invention have a beneficial action on the heart and the blood circulation and some of them possess analgesic properties. They may be administered parenterally or orally in the form of pharmaceutical preparations (e.g. tablets or dragees) containing them in admixture or conjunction with a carrier.

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