公开(公告)号：PH11206A

公开(公告)日：1977-10-28

申请号：PH17445

申请日：1975-08-04

Applicant: HOFFMANN LA ROCHE

Inventor： HAJOS Z ,  PARRISH D

IPC: C07C69/716 ,  C07C20060101 ,  C07C45/00 ,  C07C45/73 ,  C07C49/385 ,  C07C49/395 ,  C07C49/493 ,  C07C49/623 ,  C07C51/00 ,  C07C59/205 ,  C07C67/00 ,  C07D263/52 ,  C07D317/46 ,  C07D317/54 ,  C07D325/00 ,  C07J1/00

Abstract: Optically active organic compounds are prepared starting from optically inactive reactants by means of an optically active agent which influences the course of the reaction. In particular optically active compounds having a "meso" type carbon atom undergo an intramolecular ring closure in the presence of an optically active agent to yield an optically active product having one additional ring. The present process is particularly useful in the preparation of optically active bicyclic diketones which are important intermediates in the total synthesis of steroids.

公开(公告)号：DK129282B

公开(公告)日：1974-09-23

申请号：DK525169

申请日：1969-10-02

Applicant: HOFFMANN LA ROCHE

Inventor： HAJOS Z

IPC: C07C225/12 ,  C07C49/513 ,  C07C49/557 ,  C07C49/613 ,  C07C49/653 ,  C07C49/753 ,  C07C61/13 ,  C07C62/18 ,  C07C62/24 ,  C07C62/26 ,  C07C62/38 ,  C07C67/00 ,  C07C225/00 ,  C07C233/12 ,  C07C301/00 ,  C07C303/28 ,  C07C309/65 ,  C07C317/00 ,  C07D317/26 ,  C07D317/30 ,  C07J1/00 ,  C07J75/00 ,  C07C49/36

公开(公告)号：PH11762A

公开(公告)日：1978-06-27

申请号：PH19750

申请日：1977-05-09

Applicant: HOFFMANN LA ROCHE

Inventor： HAJOS Z ,  BARRISH D

IPC: C07C5/22

公开(公告)号：ZA7120B

公开(公告)日：1971-10-27

申请号：ZA7120

申请日：1971-01-04

Applicant: HOFFMANN LA ROCHE

Inventor： HAJOS Z ,  PARRISH D

IPC: C07C69/716 ,  C07C20060101 ,  C07C45/00 ,  C07C45/73 ,  C07C49/385 ,  C07C49/395 ,  C07C49/493 ,  C07C49/623 ,  C07C51/00 ,  C07C59/205 ,  C07C67/00 ,  C07D263/52 ,  C07D317/46 ,  C07D317/54 ,  C07D325/00 ,  C07J1/00

Abstract: Optically active organic compounds are prepared starting from optically inactive reactants by means of an optically active agent which influences the course of the reaction. In particular optically active compounds having a "meso" type carbon atom undergo an intramolecular ring closure in the presence of an optically active agent to yield an optically active product having one additional ring. The present process is particularly useful in the preparation of optically active bicyclic diketones which are important intermediates in the total synthesis of steroids.