公开(公告)号：MC1195A1

公开(公告)日：1979-02-23

申请号：MC1305

申请日：1978-05-26

Applicant: HOFFMANN LA ROCHE

Inventor： MONTAVON M ,  REINER R

IPC: A61K20060101 ,  A61K31/54 ,  A61K31/545 ,  A61K31/546 ,  A61P31/04 ,  C07B20060101 ,  C07D20060101 ,  C07D279/08 ,  C07D499/00 ,  C07D501/04 ,  C07D501/20 ,  C07D501/36 ,  C07D501/40 ,  C07D501/46 ,  C07B ,  C07D

公开(公告)号：DK606074A

公开(公告)日：1975-07-21

申请号：DK606074

申请日：1974-11-21

Applicant: HOFFMANN LA ROCHE

Inventor： REINER R

IPC: C07C315/04 ,  A61K31/095 ,  A61K31/10 ,  A61K31/16 ,  A61K31/22 ,  C07C20060101 ,  C07C67/00 ,  C07C313/00 ,  C07C317/32 ,  C07C

公开(公告)号：NZ198507A

公开(公告)日：1985-02-28

申请号：NZ19850781

申请日：1981-09-30

Applicant: HOFFMANN LA ROCHE

Inventor： REINER R

IPC: C07D253/06 ,  A61K31/545 ,  A61K31/546 ,  A61P31/04 ,  C07D253/075 ,  C07D501/00 ,  C07D501/18 ,  C07D501/36

Abstract: There is presented compounds of the formula I wherein X represents the 1,2,5,6-tetrahydro-2-methyl-5,6-dioxo-as-triazin-3-yl group or its corresponding tautomeric form, the 2,5-dihydro-6-hydroxy-2-methyl-5-oxo-as-triazin-3-yl group, and the readily hydrolyzable esters, readily hydrolyzable ethers and salts of the compounds and hydrates of the compounds of formula I or of their esters, ethers and salts. Also provided is a method of their manufacture and intermediates therefor as well as corresponding pharmaceutical preparations.

公开(公告)号：NZ198191A

公开(公告)日：1985-02-28

申请号：NZ19819181

申请日：1981-08-27

Applicant: HOFFMANN LA ROCHE

Inventor： MONTAVON M ,  REINER R

IPC: A61K31/546 ,  C07D249/12 ,  C07D501/36 ,  C07D501/00 ,  A61K31/545

公开(公告)号：SE431755B

公开(公告)日：1984-02-27

申请号：SE7506908

申请日：1975-06-16

Applicant: HOFFMANN LA ROCHE

Inventor： MONTAVON M ,  REINER R

IPC: C07D501/20 ,  A61K31/545 ,  A61K31/546 ,  A61P31/04 ,  C07D239/54 ,  C07D239/553 ,  C07D239/56 ,  C07D253/075 ,  C07D501/04 ,  C07D501/06 ,  C07D501/36 ,  C07D501/57 ,  F02C7/00

公开(公告)号：NZ195547A

公开(公告)日：1983-05-10

申请号：NZ19554780

申请日：1980-11-14

Applicant: HOFFMANN LA ROCHE

Inventor： MONTAVON M ,  REINER R

IPC: C07D501/00 ,  A61K31/545 ,  A61K31/546 ,  A61P31/04 ,  C07C20060101 ,  C07D20060101 ,  C07D501/04 ,  C07D501/16 ,  C07D501/36 ,  C07D501/46

Abstract: For the Contracting States : BE, CH, DE, FR, GB, IT, LI, LU, NL, SE 1. A process for the manufacture of acyl derivatives of general formula I see diagramm : EP0030294,P12,F1 in which R represents hydrogen or a readily hydrolyzable ester group, as well as of salts of these compounds and hydrates of these compounds or of their salts by reating a halide of general formula II see diagramm : EP0030294,P12,F2 in which R has the significance given above and Y represents a halogen atom, or a salt of this compound with thiourea and, if desired, converting a compound of formula I obtained into a salt or hydrate or into a hydrate of this salt, characterized in that X signifies one of the groups see diagramm : EP0030294,P13,F3 in which R' represents hydrogen or a readily hydrolysable ether group.

公开(公告)号：AU518648B2

公开(公告)日：1981-10-15

申请号：AU3658878

申请日：1978-05-29

Applicant: HOFFMANN LA ROCHE

Inventor： MONTAVON M ,  REINER R

IPC: A61K20060101 ,  A61K31/54 ,  A61K31/545 ,  A61K31/546 ,  A61P31/04 ,  C07B20060101 ,  C07D20060101 ,  C07D279/08 ,  C07D499/00 ,  C07D501/04 ,  C07D501/20 ,  C07D501/36 ,  C07D501/40 ,  C07D501/46

公开(公告)号：ZA7904083B

公开(公告)日：1980-08-27

申请号：ZA7904083

申请日：1979-08-07

Applicant: HOFFMANN LA ROCHE

Inventor： REINER R

IPC: A61K31/165 ,  A61P31/04 ,  A61K

CPC classification number: A61K31/165 ,  Y02A50/473

Abstract: The compositions contain fluoramphenicol and are prepared in a conventional manner.

公开(公告)号：ZA7903501B

公开(公告)日：1980-07-30

申请号：ZA7903501

申请日：1979-07-12

Applicant: HOFFMANN LA ROCHE

Inventor： MONTAVON M ,  REINER R

IPC: A61K20060101 ,  A61K31/545 ,  A61K31/546 ,  A61P31/04 ,  C07D20060101 ,  C07D501/36 ,  C07D501/46 ,  C07D501/56 ,  C07D ,  A61K

CPC classification number: C07D501/36

公开(公告)号：MC1259A1

公开(公告)日：1980-01-14

申请号：MC1376

申请日：1979-04-25

Applicant: HOFFMANN LA ROCHE

Inventor： MONTAVON M ,  REINER R

IPC: C07D501/04 ,  A61K20060101 ,  A61K31/545 ,  A61K31/546 ,  A61P31/04 ,  C07C20060101 ,  C07D20060101 ,  C07D501/00 ,  C07D501/16 ,  C07D501/22 ,  C07D501/36 ,  C07D501/46 ,  C07D501/56 ,  C07D501/60 ,  C07D ,  A61K