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公开(公告)号:GB2323162A
公开(公告)日:1998-09-16
申请号:GB9804445
申请日:1998-03-04
Applicant: HOWARD FOUNDATION
Inventor: BONE RICHARD ANDREW , LANDRUM JOHN THOMAS , HUANG WENLUE , ORTA CARLOS MANUEL
Abstract: In a flicker photometer to measure the level of macular pigment in the eye of a subject, a light source 1 produces two beams of light of different wavelengths that are alternately directed to the eyepiece 2 via a rotating chopper 18. The intensity of one of the beams is adjusted by the subject until no or minimal flicker is observed by the subject. The intensity adjustment means comprises a wedge-shaped attenuation filter 20 that is positioned in the path of one of the beams by an electric motor 22. In a further embodiment the light source, filter and chopper are located on a table 60 so that is moveable by means of motor 80 or handle 68 so that the photometer can be used with both short and long sighted subjects. The chopper 18 alternately allows transmission 2 of attenuated light via window 6 to the eyepiece or reflects light via its bevelled edge (186,188,figure 18) to the eyepiece. Use of the bevelled edge of the chopper leads to a compact layout.
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公开(公告)号:GB2323163B
公开(公告)日:2001-08-08
申请号:GB9804448
申请日:1998-03-04
Applicant: HOWARD FOUNDATION
Inventor: BONE RICHARD ANDREW , LANDRUM JOHN THOMAS , HUANG WENLUE , ORTA CARLOS MANUEL
Abstract: A flicker photometer comprises generating means (1, 8, 4) for generating two beams of light of different colours. Both beams are directed to a viewing means (190), and a subject can vary the intensity of light from one beam relative to the other. The colour of the light seen by the subject is caused to alternate. The performance of the photometer is improved by screens which scatter light before it reaches the subject. A first of the screens (186, 188) reflects light from one beam, whilst a second screen (b) is translucent, and thus transmits light from the other. If light of wavelengths to which the eye is less sensitive is passed through the second screen, whilst light of a wavelength to which the eye is more sensitive passes through the first screen, the screens help to make it practicable for the generating means to use a single lamp (1) to produce the light for both beams.
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公开(公告)号:NZ309130A
公开(公告)日:2001-06-29
申请号:NZ30913096
申请日:1996-06-07
Applicant: HOWARD FOUNDATION
Inventor: HOWARD ALAN NORMAN , LANDRUM JOHN THOMAS , BONE RICHARD ANDREW
IPC: A23L33/00 , A23L33/15 , A23L33/155 , A61K31/045 , A61K31/047 , A61K31/07 , A61K31/12 , A61K31/22 , A61K31/23 , A61K31/355 , A61K31/375 , A61K33/04 , A61K33/24 , A61K33/34
Abstract: A pharmaceutical composition contains meso-zeaxanthin "(3R, 3'S)-b,b-carotene-3,3'-diol" and a pharmaceutical carrier or diluent optionally with another biologically active antioxidant such as vitamin A, C or E, selenium, copper, zinc, Co enzyme Q10, lycopene or lutein useful in the treatment of macular depreciation of the yellow pigment in the macula of the eye of a human. A vegetable food containing meso-zeaxanthin optionally with lutein, which is from a genetically engineered plant, is disclosed.
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公开(公告)号:AU719671B2
公开(公告)日:2000-05-18
申请号:AU5907896
申请日:1996-06-07
Applicant: HOWARD FOUNDATION
Inventor: HOWARD ALAN NORMAN , LANDRUM JOHN THOMAS , BONE RICHARD ANDREW
IPC: A23L33/00 , A23L33/15 , A23L33/155 , A61K31/045 , A61K31/047 , A61K31/07 , A61K31/12 , A61K31/22 , A61K31/23 , A61K31/355 , A61K31/375 , A61K33/04 , A61K33/24 , A61K33/34
Abstract: The carotenoids lutein and zeaxanthin are used either separately or in combination to treat age-related macular degeneration (AMD). The carotenoids are administered in the form of a pharmaceutical preparation, e.g. a capsule or alternatively as a food e.g. a genetically engineered tomato producing enhanced levels of carotenoid. High dosages of lutein and zeaxanthin are needed to ensure high serum levels necessary for take up of the carotenoids by the macula.
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公开(公告)号:ZA982014B
公开(公告)日:1999-09-10
申请号:ZA982014
申请日:1998-03-10
Applicant: HOWARD FOUNDATION
Inventor: BONE RICHARD ANDREW , LANDRUM JOHN THOMAS , HUANG WENLUE , ORTA CARLOS MANUEL
Abstract: A flicker photometer has beam generating means (1, 8 and 4) for generating two beams of light of different colors. Light from the beams is viewed at the viewing means, and the intensity of light of one beam relative to that of the other beam can be adjusted by adjustment means comprising an attenuating filter (20) which is movably mounted in the path of one beam. Movement of the filter relative to the beam alters the degree to which the beam is attenuated, and is achieved using an electric motor (22). The motor provides a relatively easy means of adjusting the filter position, and can be used to provide coarse and fine adjustments in response to suitable signals from an optical encoder. The motor also enables the filter, along with the beam generating means, to be mounted on a movable table for use in enabling the photometer to accommodate both short and long-sighted subjects.
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公开(公告)号:CA2224217A1
公开(公告)日:1996-12-19
申请号:CA2224217
申请日:1996-06-07
Applicant: HOWARD FOUNDATION
Inventor: BONE RICHARD ANDREW , LANDRUM JOHN THOMAS , HOWARD ALAN NORMAN
IPC: A23L33/00 , A23L33/15 , A23L33/155 , A61K31/045 , A61K31/047 , A61K31/07 , A61K31/12 , A61K31/22 , A61K31/23 , A61K31/355 , A61K31/375 , A61K33/04 , A61K33/24 , A61K33/34 , A61K35/78 , A23L1/29
Abstract: The carotenoids lutein and zeaxanthin are disclosed for pharmaceutical use in the treatment of advanced macular degeneration. High dosages are deployed to produce the high serum carotenoid levels needed to cause take-up by the macula.
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公开(公告)号:CA2224217C
公开(公告)日:2010-04-13
申请号:CA2224217
申请日:1996-06-07
Applicant: HOWARD FOUNDATION
Inventor: HOWARD ALAN NORMAN , LANDRUM JOHN THOMAS , BONE RICHARD ANDREW
IPC: A61K31/047 , A23L33/00 , A23L33/15 , A23L33/155 , A61K31/01 , A61K31/015 , A61K31/045 , A61K31/07 , A61K31/12 , A61K31/22 , A61K31/23 , A61K31/355 , A61K31/375 , A61K33/04 , A61K33/24 , A61K33/30 , A61K33/32 , A61K33/34 , A61K36/185 , A61P27/00
Abstract: The carotenoids lutein and zeaxanthin are disclosed for pharmaceutical use in the treatment of advanced macular degeneration. High dosages are deployed to produce the high serum carotenoid levels needed to cause take-up by the macula.
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公开(公告)号:CA2283778C
公开(公告)日:2007-08-21
申请号:CA2283778
申请日:1998-03-04
Applicant: HOWARD FOUNDATION
Inventor: BONE RICHARD ANDREW , ORTA CARLOS MANUEL , LANDRUM JOHN THOMAS , HUANG WENLUE
Abstract: A flicker photometer comprises generating means for generating two beams of light of different colours. Both beams are directed to a viewing means and a subject can vary the intensity of light from one beam relative to other. The colour of the light seen by the subject is caused to alternate by a shutter which is rotated about an axis by a motor, the shutter having a portion which extends non-perpendicularly relative to the axis to facilitate a compact construction of photometer. The performance of the photometer is improved by screens which scatter light before it reaches the subject. A first of the screens reflects light from one beam, whilst a second screen transmits light from the other. If light of wavelengths to which the eye is less sensitive is passed through the second screen, whilst light of a wavelength to which the eye is more sensitive passes through the first screen, the screens help to make it practicable for the generating means to use a single lamp to produce the light for both beams.
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公开(公告)号:DK0831797T3
公开(公告)日:2007-04-02
申请号:DK96916256
申请日:1996-06-07
Applicant: HOWARD FOUNDATION
Inventor: HOWARD ALAN NORMAN , LANDRUM JOHN THOMAS , BONE RICHARD ANDREW
IPC: A61K31/045 , A23L33/00 , A23L33/15 , A23L33/155 , A61K31/047 , A61K31/07 , A61K31/12 , A61K31/22 , A61K31/23 , A61K31/355 , A61K31/375 , A61K33/04 , A61K33/24 , A61K33/34 , A61P27/00
Abstract: The carotenoids lutein and zeaxanthin are used either separately or in combination to treat age-related macular degeneration (AMD). The carotenoids are administered in the form of a pharmaceutical preparation, e.g. a capsule or alternatively as a food e.g. a genetically engineered tomato producing enhanced levels of carotenoid. High dosages of lutein and zeaxanthin are needed to ensure high serum levels necessary for take up of the carotenoids by the macula.
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公开(公告)号:AT355832T
公开(公告)日:2007-03-15
申请号:AT96916256
申请日:1996-06-07
Applicant: HOWARD FOUNDATION
Inventor: HOWARD ALAN NORMAN , LANDRUM JOHN THOMAS , BONE RICHARD ANDREW
IPC: A23L33/00 , A23L33/15 , A23L33/155 , A61K31/045 , A61K31/047 , A61K31/07 , A61K31/12 , A61K31/22 , A61K31/23 , A61K31/355 , A61K31/375 , A61K33/04 , A61K33/24 , A61K33/34 , A61P27/00
Abstract: The carotenoids lutein and zeaxanthin are used either separately or in combination to treat age-related macular degeneration (AMD). The carotenoids are administered in the form of a pharmaceutical preparation, e.g. a capsule or alternatively as a food e.g. a genetically engineered tomato producing enhanced levels of carotenoid. High dosages of lutein and zeaxanthin are needed to ensure high serum levels necessary for take up of the carotenoids by the macula.
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