公开(公告)号：US4093734A

公开(公告)日：1978-06-06

申请号：US734818

申请日：1976-10-22

Applicant: Gerd Kruger ,  Johannes Keck ,  Klaus Reinhold Noll ,  Helmut Pieper ,  Harald Ziegler ,  Helmut Ballhause ,  Joachim Kahling

Inventor： Gerd Kruger ,  Johannes Keck ,  Klaus Reinhold Noll ,  Helmut Pieper ,  Harald Ziegler ,  Helmut Ballhause ,  Joachim Kahling

IPC: C07D295/12 ,  A61K31/165 ,  A61K31/40 ,  A61K31/415 ,  A61K31/4402 ,  A61K31/4406 ,  A61K31/4409 ,  A61K31/4418 ,  A61K31/445 ,  A61K31/535 ,  A61K31/5375 ,  A61P1/04 ,  A61P1/08 ,  A61P25/24 ,  A61P25/26 ,  C07C237/30 ,  C07D207/09 ,  C07D211/26 ,  C07D211/56 ,  C07D211/58 ,  C07D213/40 ,  C07D213/75 ,  C07D233/30 ,  C07D295/13 ,  C07D453/02 ,  C07D207/44

CPC classification number: C07D213/40 ,  C07D207/09 ,  C07D211/26 ,  C07D211/56 ,  C07D233/30 ,  C07D295/13 ,  C07D453/02

Abstract: Compounds of the formula ##STR1## wherein (A) WHEN THE AMINO-SUBSTITUENT IS IN THE P-POSITION WITH RESPECT TO THE CARBONYL GROUP,R.sub.1 is chlorine in the o-position with respect to the carbonyl group,R.sub.2 is hydrogen, andR.sub.3 is ethylamino, cyclopentylamino, cyclohexylamino, cycloheptylamino, N-methyl-cyclohexylamino, benzylamino or 1-ethyl-pyrrolidyl-(2)-aminomethyl, or(b) when the amino-substituent is in the o--, m-- or p-position with respect to the carbonyl group,R.sub.1 is hydrogen, chlorine or bromine,R.sub.2 is trifluoromethyl, nitro or, when R.sub.4 is 1-(alkyl of 1 to 3 carbon atoms)-pyrrolidyl or 1-(alkyl of 1 to 3 carbon atoms)-piperidyl, also fluorine, chlorine, bromine or methyl,R.sub.3 is (alkyl of 1 to 5 carbon atoms)-amino, (cycloalkyl of 3 to 7 carbon atoms)-amino, benzylamino, quinuclidinyl-amino or --NH--(CH.sub.2).sub.n --R.sub.4where R.sub.4 is pyridyl, 1-(alkyl of 1 to 3 carbon atoms)-pyrrolidyl, 1-(alkyl of 1 to 3 carbon atoms)-piperidyl or, when n is 2 or 3, also imidazolonyl, pyrrolidino, piperidino or morpholino, andn is 0, 1, 2 or 3,And non-toxic, pharmacologically acceptable acid addition salts thereof; the compounds as well as their salts are useful as anxiolytics, anticonvulsives, antiemetics and antiulcerogenics.

Abstract translation: 式（A）的化合物其中（A）当氨基取代基位于与碳组相对位置时，R 1为相对于羰基的o位置的氯，R 2为氢，R 3为 是乙基氨基，环戊基氨基，环己基氨基，环庚基氨基，N-甲基 - 环己基氨基，苄基氨基或1-乙基 - 吡咯烷基 - （2） - 氨基甲基，或（B）当氨基取代基位于O-， 对于羰基，R1是氢，氯或溴，R2是三氟甲基，硝基，或当R4是1-（1至3个碳原子的烷基） - 吡咯烷基或1-（1至3个碳原子的烷基）时， - 哌啶基，氟，氯，溴或甲基，R3是（碳原子数1〜5的烷基） - 氨基，（3〜7个碳原子的环烷基） - 氨基，苄基氨基，奎宁环基 - 氨基或-NH-（CH2） n-R4，其中R4是吡啶基，1-（1至3个碳原子的烷基） - 吡咯烷基，1-（1至3个碳原子的烷基） - 哌啶基，或当n是2或3时，也是咪唑啉基，吡咯烷子基，哌啶子基 或mor pholino和N IS 0,1,2或3，以及非毒性，药理学上可接受的酸添加量; 化合物作为它们的有效的有用的ANXIOLYTICS，ANTICONVULSIVES，抗原和抗生素。

公开(公告)号：US4073942A

公开(公告)日：1978-02-14

申请号：US635220

申请日：1975-11-25

Applicant: Johannes Keck ,  Sigfrid Puschmann ,  Gerd Kruger ,  Klaus-Reinhold Noll ,  Matyas Leitold ,  Helmut Pieper

Inventor： Johannes Keck ,  Sigfrid Puschmann ,  Gerd Kruger ,  Klaus-Reinhold Noll ,  Matyas Leitold ,  Helmut Pieper

IPC: A61K31/135 ,  C07C87/29

CPC classification number: A61K31/135 ,  Y10S514/849 ,  Y10S514/925

Abstract: Compounds of the formula ##STR1## wherein X is chlorine or bromine;R.sub.1 is hydrogen, chlorine or bromine;R.sub.2 is isopropyl; tert.butyl; tert.pentyl; mono-, di- or tri-hydroxy-substituted branched alkyl of 3 to 5 carbon atoms; cyclohexyl; or hydroxycyclohexyl; andR.sub.3 is alkyl of 1 to 4 carbon atoms or, when R.sub.2 is other than cyclohexyl, also hydrogen;And non-toxic, pharmacologically acceptable acid addition salts thereof; the compounds as well as their salts are useful as secretolytics, antitussives, anti-ulcerogenics and stimulants for the production of the surfactant or anti-atelectasis factor of the alveoli.

Abstract translation: 其中X是氯或溴的式“IMAGE”的化合物; R1是氢，氯或溴; R2是异丙基; 叔丁基 叔戊基 3至5个碳原子的单，二或三羟基取代的支链烷基; 环己基 或羟基环己基; 并且R 3是1至4个碳原子的烷基，或者当R 2不是环己基时，也是氢; 和非毒性，药理学上可接受的酸添加量; 该化合物作为其生物利用作为秘密，抗生素，抗生素和抗生素用于生产ALVEOLI的表面活性剂或抗原决定因子。

公开(公告)号：US4046547A

公开(公告)日：1977-09-06

申请号：US694863

申请日：1976-06-10

Applicant: Helmut Pieper

Inventor： Helmut Pieper

IPC: C03B5/027 ,  C03B5/187 ,  C03B5/26

CPC classification number: C03B5/26 ,  C03B5/0275 ,  C03B5/1875 ,  Y02P40/57

Abstract: Glass is melted in a furnace having a melting zone and one or more processing zones adjacent to the melting zone. A volume of molten glass is caused to flow from the melting zone to the processing zone in a volume which exceeds the volume of glass withdrawn from the processing zone. The excess volume of glass is returned to the melting zone or to a separate refining zone. The furnace includes a melting section and at least one adjacent processing tank communicating with the melting section through a passage. A recirculating passage is provided between the processing tank and the melting section and additional means are provided to establish a circulating flow of molten glass via the recirculating passage.

Abstract translation: 玻璃在具有熔化区和邻近熔化区的一个或多个处理槽的炉中熔化。 熔融玻璃通过通道从熔化区流到处理槽。 熔融玻璃的一部分从处理槽的顶部排出并再循环到处理槽或单独的精炼区。 熔炉包括熔化部分和至少一个相邻的处理罐，其通过通道与熔化部分连通。 再循环通道连接处理槽的顶部和连接熔化部分和处理槽的通道。 提供附加装置以建立经由再循环通道的熔融玻璃的再循环流。

公开(公告)号：US6085551A

公开(公告)日：2000-07-11

申请号：US54294

申请日：1998-04-02

Applicant: Helmut Pieper ,  Joachim Matthes

Inventor： Helmut Pieper ,  Joachim Matthes

IPC: C03B5/04 ,  C03B5/185 ,  C03B5/193 ,  C03B5/225 ,  C03B5/18 ,  C03B5/00 ,  C03B5/16

CPC classification number: C03B5/193 ,  C03B5/04 ,  C03B5/185 ,  C03B5/225

Abstract: In the manufacturing of high melting point glasses with volatile components, in particular of glasses from the group of boron glasses and borosilicate glasses, a furnace is provided that has a superstructure, fossil fuel burners, and a melting tank. In front of a conditioning zone and a throat leading to an extraction zone, a step-shaped raised area in the bottom is provided which is formed continuously over the complete width of the melting tank. In order to suppress segregation or, respectively, phase separation, to protect the furnace construction materials and to enable problem-free operation, a temperature of at least 1600.degree. C. is produced in the superstructure by means of oxygen-rich oxidation gas, a raised area is provided in the form of a refining bank with a step in front of it, the step being at least 150 mm high and from which at least one row of booster electrodes projects upwards, before the step, the melt flows over at least one row of bubblers located in the bottom, and behind the step, the glass flows in a highly heated state over the refining bank for a distance of 800 mm to 2000 mm, the upper side of said bank being at a maximum distance "T" of 300 mm from the glass bath surface.

Abstract translation: 在具有挥发性成分的高熔点玻璃的制造中，特别是来自硼玻璃和硼硅酸盐玻璃的玻璃中，提供了具有上层结构，化石燃料燃烧器和熔化槽的炉。 在调节区域和通向提取区域的喉管前方，提供了在熔池的整个宽度上连续形成的底部的台阶形凸起区域。 为了抑制偏析或相分离，为了保护炉结构材料并使其无故障运行，通过富氧氧化气体在上层结构中产生至少1600℃的温度， 凸起区域以其前面的台阶形式提供为精制库，该步骤至少为150mm高，并且至少一排增压电极向上突出，在步骤之前，熔体至少流过至少 位于底部的一排起泡器，并且在台阶之后，玻璃在高度加热状态下在精炼库上流动800mm至2000mm的距离，所述堤的上侧处于最大距离“T” 距玻璃浴表面300毫米。

公开(公告)号：US5994356A

公开(公告)日：1999-11-30

申请号：US832259

申请日：1997-04-03

Applicant: Helmut Pieper ,  Gunter Linz ,  Volkhard Austel ,  Frank Himmelsbach ,  Brian Guth ,  Johannes Weisenberger

Inventor： Helmut Pieper ,  Gunter Linz ,  Volkhard Austel ,  Frank Himmelsbach ,  Brian Guth ,  Johannes Weisenberger

IPC: C07D295/08 ,  A61K31/00 ,  A61K31/4427 ,  A61K31/443 ,  A61K31/445 ,  A61K31/495 ,  A61K31/496 ,  A61K31/50 ,  A61K31/501 ,  A61P7/00 ,  A61P7/02 ,  C07D211/22 ,  C07D211/26 ,  C07D211/34 ,  C07D211/46 ,  C07D211/58 ,  C07D295/20 ,  C07D401/04 ,  C07D401/08 ,  C07D401/14 ,  C07D405/14 ,  C07D403/06 ,  C07D403/12 ,  C07D403/14

CPC classification number: C07D211/46 ,  C07D211/22 ,  C07D211/26 ,  C07D211/58

Abstract: The present invention relates to carboxylic acid derivatives of the general formula ##STR1## in which R.sub.a to R.sub.c, A, B, D, E and X.sub.1 to X.sub.3 are as defined in claim 1, their tautomers, their stereoisomers including their mixtures, and their salts, in particular their physiologically tolerated salts with inorganic or organic acids or bases, which have useful pharmacological properties, preferably aggregation-inhibiting inhibiting actions, medicaments containing these compounds, their use and processes for their preparation.

Abstract translation: 本发明涉及下列通式的羧酸衍生物，其中Ra至Rc，A，B，D，E和X 1至X 3如权利要求1所定义，其互变异构体，其立体异构体包括它们的混合物及其盐， 特别是其具有有用的药理学特性，优选聚集抑制抑制作用的无机或有机酸或碱的生理学耐受盐，其含有这些化合物的药物，其用途及其制备方法。

公开(公告)号：US5922717A

公开(公告)日：1999-07-13

申请号：US576528

申请日：1995-12-21

Applicant: Helmut Pieper ,  Volkhard Austel ,  Frank Himmelsbach ,  Gunter Linz ,  Brian Guth ,  Johannes Weisenberger

Inventor： Helmut Pieper ,  Volkhard Austel ,  Frank Himmelsbach ,  Gunter Linz ,  Brian Guth ,  Johannes Weisenberger

IPC: A61K31/495 ,  A61P7/02 ,  C07D207/14 ,  C07D211/34 ,  C07D211/58 ,  A61K31/445 ,  C07D401/06

CPC classification number: C07D211/58 ,  C07D211/34

Abstract: The present invention relates to piperazine derivatives of the general formula ##STR1## in which R.sub.a, Y.sub.1 to Y.sub.3 and E are defined herein, tautomers thereof, stereoisomers thereof, including their mixtures, and salts thereof, and in particular physiologically tolerated salts thereof with inorganic or organic acids or bases. These compounds have valuable pharmacological properties, such as aggregation-inhibiting activity. This invention also relates to medicaments comprising these compounds and to processes for the preparation of these compounds.

Abstract translation: 本发明涉及其中Ra，Y1至Y3和E如本文所定义的通式的哌嗪衍生物，其互变异构体，其立体异构体，包括它们的混合物及其盐，特别是其与无机或有机酸的生理学上可接受的盐 或碱基。 这些化合物具有有价值的药理学性质，例如聚集抑制活性。 本发明还涉及包含这些化合物的药物和制备这些化合物的方法。

公开(公告)号：US5681841A

公开(公告)日：1997-10-28

申请号：US120008

申请日：1993-09-10

Applicant: Frank Himmelsbach ,  Volkhard Austel ,  Gunter Linz ,  Helmut Pieper ,  Brian Guth ,  Thomas Muller ,  Johannes Weisenberger

Inventor： Frank Himmelsbach ,  Volkhard Austel ,  Gunter Linz ,  Helmut Pieper ,  Brian Guth ,  Thomas Muller ,  Johannes Weisenberger

IPC: A61K31/41 ,  A61K31/395 ,  A61K31/415 ,  A61K31/4166 ,  A61K31/435 ,  A61K31/4427 ,  A61K31/445 ,  A61P7/02 ,  A61P9/10 ,  A61P35/00 ,  A61P43/00 ,  C07C281/06 ,  C07D233/02 ,  C07D233/32 ,  C07D233/36 ,  C07D233/44 ,  C07D233/70 ,  C07D233/72 ,  C07D235/26 ,  C07D239/10 ,  C07D249/12 ,  C07D401/04 ,  C07D401/06 ,  C07D401/10 ,  C07D401/14 ,  C07D417/06 ,  C07D453/02 ,  C07D487/08

CPC classification number: C07D401/04 ,  C07D233/36 ,  C07D233/44 ,  C07D233/70 ,  C07D233/72 ,  C07D235/26 ,  C07D239/10 ,  C07D249/12 ,  C07D401/06 ,  C07D401/10 ,  C07D417/06 ,  C07D453/02

Abstract: The invention relates to cyclic urea derivatives of general formula I ##STR1## wherein R.sub.a, R.sub.b, X and Y are defined as in claim 1, the tautomers, stereoisomers and salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases, which have valuable pharmacological properties, preferably aggregation inhibiting effects, and to drugs containing the compounds and processes for preparing them.

Abstract translation: 本发明涉及通式I（I）的环脲衍生物，其中Ra，Rb，X和Y如权利要求1所定义，其互变异构体，立体异构体和盐，特别是其与无机或有机物的生理上可接受的盐 具有有价值的药理学性质，优选聚集抑制作用的酸或碱，以及含有这些化合物的药物及其制备方法。

公开(公告)号：US5600669A

公开(公告)日：1997-02-04

申请号：US570136

申请日：1995-12-11

Applicant: Helmut Pieper

Inventor： Helmut Pieper

IPC: C03B5/027 ,  C03B5/167 ,  H05B3/03

CPC classification number: C03B5/027 ,  H05B3/03

Abstract: An electrode assembly for glass tank furnaces comprises a rod electrode inserted in a cylindrical electrode holder, through which it can be advanced. Along at least part of its length the said electrode holder is fitted with a device for forced cooling and is installed in an electrode block in the furnace. In order to dispense with and in order to operate the electrode holder at a constant temperature the holder is inserted with the bottom face below a filling level determined by the design of the furnace, and provided with a seal between it and the electrode above the filling level. Preferably the electrode holder has an outer tube and an inner tube, which create an annular gap between them for a cooling medium, whereby the inner tube protrudes out of the upper end of the outer tube and a sealing unit is provided between the inner tube and the electrode.

Abstract translation: 用于玻璃罐炉的电极组件包括插入圆柱形电极座中的杆电极，通过该杆电极可推进。 沿着其长度的至少一部分，所述电极保持器装配有用于强制冷却的装置，并且安装在炉中的电极块中。 为了省去并且为了在恒定温度下操作电极保持器，保持器被插入，其底面低于由炉的设计确定的填充水平，并且在其与填充物之上的电极之间设置有密封 水平。 优选地，电极保持器具有外管和内管，其在它们之间形成用于冷却介质的环形间隙，由此内管从外管的上端突出，并且密封单元设置在内管和 电极。

公开(公告)号：US5455348A

公开(公告)日：1995-10-03

申请号：US173603

申请日：1993-12-23

Applicant: Volkhard Austel ,  Wolfgang Eisert ,  Frank Himmelsbach ,  Guenter Linz ,  Thomas Mueller ,  Helmut Pieper ,  Johannes Weisenberger

Inventor： Volkhard Austel ,  Wolfgang Eisert ,  Frank Himmelsbach ,  Guenter Linz ,  Thomas Mueller ,  Helmut Pieper ,  Johannes Weisenberger

IPC: A61K31/44 ,  A61K31/4427 ,  A61K31/47 ,  A61K31/55 ,  A61P7/02 ,  A61P9/10 ,  A61P35/00 ,  C07D207/26 ,  C07D401/04 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D403/06 ,  C07D403/12 ,  C07D405/06 ,  C07D405/12 ,  C07D409/12 ,  C07D417/04 ,  C07D417/06 ,  C07D417/12 ,  C07D417/14 ,  C07D521/00

CPC classification number: C07D207/26 ,  C07D231/12 ,  C07D233/56 ,  C07D249/08 ,  C07D401/04 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D403/06 ,  C07D403/12 ,  C07D405/06 ,  C07D405/12 ,  C07D409/12 ,  C07D417/04 ,  C07D417/06 ,  C07D417/12

Abstract: The invention relates to cyclic imino derivatives of general formulaB--X.sub.5 --X.sub.4 --X.sub.3 --X.sub.2 --X.sub.1 --A--Y--E(I)whereinA, B, E, X.sub.2 to X.sub.5 and Y are defined as in claim 1, the stereoisomers, tautomers, mixtures and salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases, which have valuable pharmacological properties, preferably aggregation-inhibiting effects, pharmaceutical compositions which contain these compounds and processes for preparing them.

Abstract translation: 本发明涉及通式B-X5-X4-X3-X2-X1-AYE（Ⅰ）的环亚氨基衍生物，其中A，B，E，X 2至X 5和Y如权利要求1中所定义，立体异构体，互变异构体， 特别是其与无机或有机酸或碱的生理上可接受的盐，其具有有价值的药理学性质，优选聚集抑制作用，含有这些化合物的药物组合物及其制备方法。

公开(公告)号：US5418233A

公开(公告)日：1995-05-23

申请号：US961135

申请日：1992-10-14

Applicant: Guenter Linz ,  Helmut Pieper ,  Frank Himmelsbach ,  Austel: Volkhard ,  Thomas Mueller ,  Johannes Weisenberger ,  Elke Seewaldt-Becker

Inventor： Guenter Linz ,  Helmut Pieper ,  Frank Himmelsbach ,  Austel: Volkhard ,  Thomas Mueller ,  Johannes Weisenberger ,  Elke Seewaldt-Becker

IPC: A61K31/44 ,  A61K31/4402 ,  A61K31/4406 ,  A61K31/4409 ,  A61K31/4418 ,  A61K31/4425 ,  A61K31/4427 ,  A61K31/445 ,  A61K31/495 ,  A61K31/50 ,  A61K31/505 ,  A61P7/02 ,  A61P29/00 ,  A61P35/00 ,  C07D213/75 ,  C07D213/81 ,  C07D237/14 ,  C07D237/20 ,  C07D237/24 ,  C07D239/28 ,  C07D239/34 ,  C07D239/36 ,  C07D241/20 ,  C07D401/06 ,  C07D401/12 ,  C07D417/12 ,  C07F9/40 ,  C07F9/6509

CPC classification number: C07D239/36 ,  C07D237/14 ,  C07D237/20 ,  C07D237/24 ,  C07D401/06 ,  C07D401/12 ,  C07F9/650941

Abstract: Heterobiaryl derivatives of the formulaR.sub.1 NH--X.sub.1 --X.sub.2 --X.sub.3 --Y.sub.1 --Y.sub.2 --Y.sub.3 --Y.sub.4 --E (I)whereinR.sub.1, X.sub.1 to X.sub.3 and Y.sub.1 to Y.sub.4 are as defined herein, the tautomers, stereoisomers and mixtures thereof, and the salts, particularly the physiologically acceptable salts, thereof with organic or inorganic acids or bases. The derivatives have valuable pharmacological properties, such as inhibiting cell-cell aggregation and cell-matrix interactions.

Abstract translation: 式R1NH-X1-X2-X3-Y1-Y2-Y3-Y4-E（Ⅰ）的杂芳基衍生物其中R1，X1至X3和Y1至Y4如本文所定义，互变异构体，立体异构体及其混合物，以及 盐，特别是其生理上可接受的盐与有机或无机酸或碱反应。 该衍生物具有有价值的药理学性质，例如抑制细胞 - 细胞聚集和细胞 - 基质相互作用。