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    IMPROVED RADIOTHERAPY
    11.
    发明申请
    IMPROVED RADIOTHERAPY 审中-公开
    改进的放射治疗

    公开(公告)号：WO1989010158A1

    公开(公告)日：1989-11-02

    申请号：PCT/US1989001692

    申请日：1989-04-26

    Applicant: IMMUNOMEDICS, INC.

    Inventor： IMMUNOMEDICS, INC. ,  GOLDENBERG, Milton, David

    IPC: A61N01/30

    CPC classification number: A61K38/193 ,  A61K38/2006 ,  A61K38/2013 ,  A61K38/202

    Abstract: External beam radiation therapy of cancer and other abnormal proliferative processes, and immunosuppression of transplant candidates, is improved using cytokines to prevent, mitigate or reverse adverse radiation-induced toxicity, especially to hematopoietic cells. A preferred cytokine is IL-1. Higher doses of radiation can be administered and tolerated by the patient and dose-limiting marrow toxicity can be prevented, palliated or reversed using adjunct cytokine therapy.

    INTRAOPERATIVE AND ENDOSCOPIC TUMOR DETECTION AND THERAPY
    14.
    发明申请
    INTRAOPERATIVE AND ENDOSCOPIC TUMOR DETECTION AND THERAPY 审中-公开
    内分泌和内镜肿瘤检测和治疗

    公开(公告)号：WO1988004537A1

    公开(公告)日：1988-06-30

    申请号：PCT/US1987003384

    申请日：1987-12-17

    Applicant: IMMUNOMEDICS, INC.

    Inventor： IMMUNOMEDICS, INC. ,  GOLDENBERG, Milton, David

    IPC: A61B06/00

    CPC classification number: A61K51/1045 ,  A61B6/4258 ,  A61K2123/00

    Abstract: Methods for short-range intraoperative and endoscopic detection and therapy of tumors using radiolabeled antibodies and, in some cases, techniques for reducing or correcting for non-specific background radiation to improve resolution. Therapy using external radiation and/or laser or mechanical endoscopically introduced tumor removal means can be combined with the detection methods to increase precision of the tumor removal operations.

    Abstract translation: 使用放射性标记的抗体的短程术中和内窥镜检测和肿瘤治疗的方法，以及在一些情况下用于减少或校正非特异性背景辐射以提高分辨率的技术。 使用外部辐射和/或激光或机械内窥镜引入的肿瘤去除手段的治疗可以与检测方法组合以提高肿瘤去除操作的精度。

    IMPROVED DETECTION AND THERAPY OF LESIONS WITH BIOTIN-CHELATE CONJUGATES
    16.
    发明申请
    IMPROVED DETECTION AND THERAPY OF LESIONS WITH BIOTIN-CHELATE CONJUGATES 审中-公开
    改进的生物柴油凝胶的检测和治疗

    公开(公告)号：WO1998004293A1

    公开(公告)日：1998-02-05

    申请号：PCT/US1997013285

    申请日：1997-07-31

    Applicant: IMMUNOMEDICS, INC. ,  GRIFFITHS, Gary, L. ,  HANSEN, Hans, J. ,  KARACAY, Habibe

    Inventor： IMMUNOMEDICS, INC.

    IPC: A61K51/00

    CPC classification number: A61K49/10 ,  A61K49/085 ,  A61K49/14 ,  A61K51/0497 ,  B82Y5/00

    Abstract: An improved method of detecting and/or treating lesions in a patient in which a pre-targeting approach is used wherein the total amount of radionuclide delivered to a target cell, tissue, or pathogen is dramatically increased. In this method, the chelate conjugate may be purified by chromatography after chelate formation, may contain multiple chelates or a blood transit-modifying linker or added within the chelate conjugate, or both; or a combination of these. The improved chelate conjugates can be used as detection of therapeutic agents to detect or treat the targeted cell, tissue, or pathogen.

    Abstract translation: 一种用于检测和/或治疗患者中的损伤的改进方法，其中使用预靶向方法，其中递送至靶细胞，组织或病原体的放射性核素的总量显着增加。 在该方法中，螯合物形成后可以通过色谱法纯化螯合物缀合物，可以含有多个螯合物或血液转运修饰接头或加入到螯合缀合物内，或两者都可以。 或这些的组合。 改进的螯合物可用作检测或治疗靶细胞，组织或病原体的治疗剂的检测。

    RADIOMETAL-BINDING ANALOGUES OF LEUTENIZING HORMONE RELEASING HORMONE
    17.
    发明申请
    RADIOMETAL-BINDING ANALOGUES OF LEUTENIZING HORMONE RELEASING HORMONE 审中-公开
    去除激素释放激素的放射线结合模拟

    公开(公告)号：WO1996040756A1

    公开(公告)日：1996-12-19

    申请号：PCT/US1996008695

    申请日：1996-06-07

    Applicant: IMMUNOMEDICS, INC.

    Inventor： IMMUNOMEDICS, INC. ,  McBRIDE, William, J. ,  KARACAY, Habibe ,  GRIFFITHS, Gary, L.

    IPC: C07K07/23

    CPC classification number: C07K7/23 ,  A61K38/00 ,  A61K51/088

    Abstract: Peptide derivatives of leutenizing hormone releasing hormone that are capable of binding radionuclides are provided. The peptide derivatives are readily labeled with isotopes of rhenium or technetium, while retaining their ability to tightly bind LHRH receptors. Methods for preparing the labeled peptides and their use in methods of radiodiagnosis and radiotherapy are described.

    Abstract translation: 提供了能够结合放射性核素的促黄体激素释放激素的肽衍生物。 肽衍生物容易用铼或锝的同位素标记，同时保持其紧密结合LHRH受体的能力。 描述了制备标记肽的方法及其在放射诊断和放射治疗方法中的应用。

    THIOLATION OF PEPTIDES FOR RADIONUCLIDE-BASED RADIODETECTION AND RADIOTHERAPY
    18.
    发明申请
    THIOLATION OF PEPTIDES FOR RADIONUCLIDE-BASED RADIODETECTION AND RADIOTHERAPY 审中-公开
    基于放射性核素的放射治疗和放射治疗的肽的断裂

    公开(公告)号：WO1996040289A1

    公开(公告)日：1996-12-19

    申请号：PCT/US1996008693

    申请日：1996-06-07

    Applicant: IMMUNOMEDICS, INC. ,  GOVINDAN, Serengulam, V. ,  GRIFFITHS, Gary, L. ,  HANSEN, Hans, L.

    Inventor： IMMUNOMEDICS, INC.

    IPC: A61K51/00

    CPC classification number: A61K51/088 ,  A61K51/083

    Abstract: A method of radiolabeling a peptide, e.g., somatostatin or an analogue thereof or vasoactive intestinal peptide, with a radioisotope of technetium or rhenium, comprises the steps of: (a) reacting the peptide with an acetyl-protected t -thiol-containing, amine-reactive bifunctional chelating agent; (b) deprotecting the acetyl- t -thiol group to generate a free t -thiol group; and either (c) admixing the peptide- t -thiol-containing conjugate with a stannous salt; and (d) reacting the mixture of step (c) with pertechnetate or perrhenate, or (c') adding reduced pertechnetate or perrhenate to said peptide- t -thiol-containing conjugate, thereby forming a radiolabeled peptide. Kits for effecting the radiolabeling method, and methods of tumor detection/imaging or therapy are provided.

    Abstract translation: 将肽，例如生长抑素或其类似物或血管活性肠肽与锝或铼的放射性同位素放射标记的方法包括以下步骤：（a）使肽与乙酰基保护的u 含硫醇的胺反应性双功能螯合剂; （b）使乙酰基-t硫醇基脱保护以产生游离叔硫醇基团; 并且（c）将含有肽-TH-硫醇的缀合物与亚锡盐混合; 和（d）使步骤（c）的混合物与高锝酸盐或高铼酸盐反应，或（c'）向所述含有肽-TH-硫醇的缀合物加入减少的高锝酸盐或高铼酸盐，由此形成放射性标记的肽 。 提供了用于实现放射性标记方法的试剂盒，以及肿瘤检测/成像或治疗方法。

    THIOLATION OF PROTEINS FOR RADIONUCLIDE-BASED RADIOIMMUNODETECTION AND RADIOIMMUNOTHERAPY
    20.
    发明申请
    THIOLATION OF PROTEINS FOR RADIONUCLIDE-BASED RADIOIMMUNODETECTION AND RADIOIMMUNOTHERAPY 审中-公开
    基于放射性核素的放射性免疫球蛋白的测定和放射免疫学

    公开(公告)号：WO1995033495A1

    公开(公告)日：1995-12-14

    申请号：PCT/US1995005539

    申请日：1995-05-08

    Applicant: IMMUNOMEDICS, INC.

    Inventor： IMMUNOMEDICS, INC. ,  GOVINDAN, Seregulam, V. ,  GREBENAU, Ruth ,  GRIFFITHS, Gary, L. ,  HANSEN, Hans, J.

    IPC: A61K51/08

    CPC classification number: A61K51/1093 ,  A61K51/1048 ,  A61K2121/00 ,  A61K2123/00

    Abstract: A method of radiolabeling a protein with a radionuclide including contacting the protein with a protected tertiary thiol-containing bifunctional chelating agent that is capable of reacting with the protein at one end of the agent and is capable of complexing with a radionuclide at the other end of the agent, to form a protein-acetyl- t -thiol-containing conjugate. The protein-acetyl- t -thiol-containing conjugate then is deprotected and admixed with a reducing agent for the radionuclide, where the radionuclide is added in a subsequent step, to form a mixture of reducing agent and protein- t -thiol-containing conjugate. This mixture then is reacted with a radionuclide whereby the radionuclide reacts with pendant sulfhydryl groups present on the protein- t -thiol-containing conjugate. Methods of radioimmunotherapy and diagnostic kits suitable for forming a composition to be administered to a human patient also are disclosed.

    Abstract translation: 一种用放射性核素放射性标记蛋白质的方法，包括使蛋白质与受保护的含叔硫醇的双功能螯合剂接触，所述螯合剂能够在所述试剂的一端与蛋白质反应，并且能够与另一端的放射性核素络合 该试剂形成含蛋白质 - 乙酰基 - 硫醇的缀合物。 然后将含蛋白质 - 乙酰基 - 硫醇的缀合物脱保护并与用于放射性核素的还原剂混合，其中放射性核素在随后的步骤中加入以形成还原剂和蛋白质的混合物 - 含硫醇的缀合物。 然后将该混合物与放射性核素反应，由此放射性核素与存在于含有蛋白质 - 硫醇的缀合物上的侧链巯基反应。 还公开了放射免疫治疗方法和适合于形成待给予人类患者的组合物的诊断试剂盒。

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