公开(公告)号：EP2663641B1

公开(公告)日：2018-03-28

申请号：EP12703604.4

申请日：2012-01-10

Applicant: InteRNA Technologies B.V.

Inventor： WEIJZEN, Sanne ,  SCHAAPVELD, Roeland Quirinus Jozef ,  BOURAJJAJ, Meriem ,  VAN HAASTERT, Rick Jan ,  GRIFFIOEN, Arjan Willem ,  VAN BEIJNUM, Judith Rosina ,  CUPPEN, Edwin Pieter Johan Gerard ,  BEREZIKOV, Eugene ,  VAN PUIJENBROEK, Andreas Alphons Franciscus Ludovicus ,  GOMMANS, Willemijn Maria ,  BABAE, Negar ,  VAN NOORT, Petronella Innocentia

IPC: C12N15/113 ,  A61K31/7105 ,  A61K31/713 ,  A61P35/00

CPC classification number: C12N15/1135 ,  A61P35/00 ,  C12N7/00 ,  C12N15/113 ,  C12N2310/141 ,  C12N2320/10 ,  C12N2320/11 ,  C12N2320/30 ,  C12N2320/31 ,  C12N2710/10043 ,  C12N2740/15043 ,  C12Q1/6883 ,  C12Q1/6886

Abstract: The invention relates to the diagnostic and therapeutic uses of a miRNA-574 molecule, an equivalent or a source thereof in a disease and condition associated with neo-angiogenesis.

公开(公告)号：EP2663641A1

公开(公告)日：2013-11-20

申请号：EP12703604.4

申请日：2012-01-10

Applicant: InteRNA Technologies B.V.

Inventor： WEIJZEN, Sanne ,  SCHAAPVELD, Roeland Quirinus Jozef ,  BOURAJJAJ, Meriem ,  VAN HAASTERT, Rick Jan ,  GRIFFIOEN, Arjan Willem ,  VAN BEIJNUM, Judith Rosina ,  CUPPEN, Edwin Pieter Johan Gerard ,  BEREZIKOV, Eugene ,  VAN PUIJENBROEK, Andreas Alphons Franciscus Ludovicus ,  GOMMANS, Willemijn Maria ,  BABAE, Negar ,  VAN NOORT, Petronella Innocentia

IPC: C12N15/113 ,  A61K31/7105 ,  A61K31/713 ,  A61P35/00

CPC classification number: C12N15/1135 ,  A61P35/00 ,  C12N7/00 ,  C12N15/113 ,  C12N2310/141 ,  C12N2320/10 ,  C12N2320/11 ,  C12N2320/30 ,  C12N2320/31 ,  C12N2710/10043 ,  C12N2740/15043 ,  C12Q1/6883 ,  C12Q1/6886

Abstract: The invention relates to the diagnostic and therapeutic uses of a miRNA-574 molecule, an equivalent or a source thereof in a disease and condition associated with neo-angiogenesis.

Abstract translation: 本发明涉及在与新血管生成相关的疾病和病症中的miRNA-574分子，其等同物或来源的诊断和治疗用途。

公开(公告)号：EP4110917A1

公开(公告)日：2023-01-04

申请号：EP21706991.3

申请日：2021-02-26

Applicant: InteRNA Technologies B.V.

Inventor： YAHYANEJAD, Sanaz ,  TELFORD, Bryony ,  VAN DEN BOSCH, Marion ,  ALEMDEHY, Mir Farshid ,  DE GUNST, Matheus Maria ,  VAN PINXTEREN, Laurens Adrianus Hendricus ,  SCHAAPVELD, Roeland Quirinus Jozef ,  JANICOT, Michel

IPC: C12N15/113

公开(公告)号：EP4013869A1

公开(公告)日：2022-06-22

申请号：EP20707290.1

申请日：2020-03-06

Applicant: InteRNA Technologies B.V.

Inventor： YAHYANEJAD, Sanaz ,  TELFORD, Bryony Jane ,  VAN DEN BOSCH, Marion Tina Jolien ,  ALEMDEHY, Mir Farshid ,  DE GUNST, Matheus Maria ,  VAN PINXTEREN, Laurens Adrianus Hendricus ,  SCHAAPVELD, Roeland Quirinus Jozef ,  JANICOT, Michel

IPC: C12N15/113

公开(公告)号：EP3704250A1

公开(公告)日：2020-09-09

申请号：EP18795661.0

申请日：2018-11-02

Applicant: InteRNA Technologies B.V.

Inventor： VAN BATTUM, Eljo Y. ,  VANGOOR, Vamshi R. ,  DERIJCK, Alwin A.H.A ,  SCHAAPVELD, Roeland Quirinus Jozef ,  PASTERKAMP, R. Jeroen

IPC: C12N15/113 ,  A61K31/713 ,  C12Q1/68

公开(公告)号：EP3158083A1

公开(公告)日：2017-04-26

申请号：EP15738759.8

申请日：2015-06-19

Applicant: Stichting VU-VUmc ,  InteRNA Technologies B.V.

Inventor： MEIJER, Gerrit Albert ,  DIOSDADO, Begoña ,  TIMMER, Lisette M. ,  CUPPEN, Edwin Pieter Johan Gerard ,  BEREZIKOV, Eugene ,  CERISOLI, Francesco ,  SCHAAPVELD, Roeland Quirinus Jozef

IPC: C12Q1/68

CPC classification number: C12Q1/6886 ,  C12Q2600/158 ,  C12Q2600/16 ,  C12Q2600/178

Abstract: Methods of diagnosing colorectal cancer and precursors thereof using miRNA biomarkers are disclosed, together with kits and devices for detecting the biomarkers, and uses of the biomarkers. The biomarkers described are reliably detected in stool and demonstrate significantly different expression levels in colorectal cancer patients when compared to colorectal cancer negative patients.

Abstract translation: 公开了使用miRNA生物标志物诊断结肠直肠癌及其前体的方法，以及用于检测生物标志物的试剂盒和设备以及生物标志物的用途。 所描述的生物标志物在大便中可靠地检测到，并且与结肠直肠癌阴性患者相比在结肠直肠癌患者中表现出显着不同的表达水平。

公开(公告)号：EP2917348A1

公开(公告)日：2015-09-16

申请号：EP13788743.6

申请日：2013-11-06

Applicant: InteRNA Technologies B.V.

Inventor： VAN HAASTERT, Rick Jan ,  VAN NOORT, Petronella Innocentia ,  PREVOST, Grégoire Pierre André ,  GOMMANS, Willemijn Maria ,  SCHAAPVELD, Roeland Quirinus Jozef ,  DE GUNST, Matheus Maria ,  SCHULTZ, Iman Johannes ,  BEREZIKOV, Eugene

IPC: C12N15/113 ,  A61P35/00 ,  A61K31/713

CPC classification number: A61K31/713 ,  A61K31/4184 ,  A61K31/437 ,  A61K31/506 ,  A61K31/519 ,  C12N15/1135 ,  C12N2310/113 ,  C12N2310/141 ,  C12N2320/10 ,  C12N2320/31 ,  C12N2330/10 ,  A61K2300/00

Abstract: The invention relates to the therapeutic use of a combination in a disease and condition associated with melanoma or a disease or a condition associated with activated BRAF pathway.

Abstract translation: 本发明涉及与黑素瘤或疾病或与活化的BRAF途径相关的病症有关的疾病和病症的治疗用途的组合。

公开(公告)号：EP2542678A1

公开(公告)日：2013-01-09

申请号：EP11708936.7

申请日：2011-03-04

Applicant: InteRNA Technologies B.V.

Inventor： SCHAAPVELD, Roeland Quirinus Jozef ,  VERHAEGH, Gerardus Wilhelmus Christiaan Theodoor ,  SCHALKEN, Jacobus Antonius ,  VAN PUIJENBROEK, Andreas Alphons Franciscus Ludovicus ,  GOMMANS, Willemijn Maria ,  WEIJZEN, Sanne

IPC: C12N15/113 ,  A61K31/7105 ,  A61P35/04

CPC classification number: C12N15/1138 ,  A61K31/7088 ,  A61K31/7105 ,  A61K31/713 ,  A61K45/06 ,  A61N5/10 ,  C12N15/113 ,  C12N2310/141 ,  C12N2320/31 ,  C12N2330/10

Abstract: The invention relates to the diagnostic and therapeutic uses of a miRNA molecule or an equivalent thereof wherein a source of said miRNA molecule or equivalent thereof comprises at least 80 nucleotides and comprises a motif having at least 98% identity with the motif represented by SEQ ID NO:1 or a source thereof in a disease and condition associated with EMT (Epithelial to Mesenchymal Transition).