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Patent Agency Ranking11.发明申请METHODS OF PRODUCING 7-CARBON CHEMICALS VIA CARBON CHAIN ELONGATION ASSOCIATED WITH CYCLOHEXANE CARBOXYLATE SYNTHESIS 审中-公开通过碳环化合物合成生成碳碳化合物通过碳链延伸的方法
公开(公告)号：WO2014105788A2
公开(公告)日：2014-07-03
申请号：PCT/US2013/077411
申请日：2013-12-23
Applicant: INVISTA NORTH AMERICA S.A.R.L.
Inventor： BOTES, Adriana Leonora , CONRADIE, Alex Van Eck , CHEN, Changlin , PEARLMAN, Paul S.
CPC classification number: C12P13/001 , C12N9/0008 , C12N9/1096 , C12N9/16 , C12P7/18 , C12P7/42 , C12P7/44 , C12P13/002 , C12Y102/99006 , C12Y301/02002
Abstract: This document describes biochemical pathways for producing pimelic acid, 7-aminoheptanoic acid, 7-hydroxyheptanoic acid, heptamethylenediamine or 1,7-heptanediol by forming two terminal functional groups, comprised of carboxyl, amine or hydroxyl group, in a C7 aliphatic backbone substrate. These pathways, metabolic engineering and cultivation strategies described herein rely on the carbon chain elongation enzymes or homologs thereof associated with the cyclohexane carboxylate biosynthesis from Syntrophus aciditrophicus or 2-aminoadipate lysine biosynthesis.
Abstract translation: 该文献描述了通过在C7脂肪族主链基质中形成由羧基，胺或羟基组成的两个末端官能团来生产庚二酸，7-氨基庚酸，7-羟基庚酸，七亚甲基二胺或1,7-庚二醇的生化途径。 本文描述的这些途径，代谢工程和培养策略依赖于与酸性营养不良食物或2-氨基己二酸赖氨酸生物合成的环己烷羧酸盐生物合成相关的碳链延长酶或其同系物。
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公开(公告)号：WO2015017404A1
公开(公告)日：2015-02-05
申请号：PCT/US2014/048606
申请日：2014-07-29
Applicant: INVISTA NORTH AMERICA S.A.R.L.
Inventor： CONRADIE, Alex Van Eck , BOTES, Adriana Leonora
CPC classification number: C12P19/32 , C12N9/1029 , C12P7/26 , C12P7/40 , C12Y203/01016
Abstract: This document describes biochemical pathways that include the production of 3-oxopent-4-enoyl-CoA by condensation of acryloyl-CoA and acetyl-CoA using a β-ketothiolase with a SER-HIS-HIS catalytic triad. These pathways described herein rely on enzymes such as, inter alia, dehydrogenases, dehydratases and β-ketothiolases .
Abstract translation: 本文件描述了生物化学途径，其包括通过使用α-氧化还原酶与SER-HIS-HIS催化三单元组缩合丙烯酰辅酶A和乙酰辅酶A来生产3-氧代-4-烯酰辅酶A。 本文描述的这些途径依赖于酶，例如脱氢酶，脱水酶和β-酮硫解酶。
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13.发明申请METHODS OF PRODUCING 7-CARBON CHEMICALS VIA PYRUVATE AND SUCCINATE SEMIALDEHYDE ALDOL CONDENSATION 审中-公开生产七碳化合物的方法通过吡咯烷酸和己二酸二乙醇醇缩合反应
公开(公告)号：WO2014105797A2
公开(公告)日：2014-07-03
申请号：PCT/US2013/077430
申请日：2013-12-23
Applicant: INVISTA NORTH AMERICA S.A.R.L.
Inventor： BOTES, Adriana Leonora , CONRADIE, Alex Van Eck , CHEN, Changlin , PEARLMAN, Paul S.
CPC classification number: C12P7/40 , C12N9/0006 , C12N15/52 , C12P7/18 , C12P7/24 , C12P7/42 , C12P7/44 , C12P13/001 , C12P13/002
Abstract: This document describes biochemical pathways for producing one or more of pimelic acid, 7-aminoheptanoic acid, 7-hydroxyheptanoic acid, heptamethylenediamine and 1,7-heptanediol by forming one or two terminal functional groups, comprised of carboxyl, amine or hydroxyl groups, in a C7 aliphatic backbone substrate produced from succinate semialdehyde or pyruvate. These pathways, metabolic engineering and cultivation strategies described herein rely on the aldol condensation of succinate semialdehyde and pyruvate.
Abstract translation: 本文件描述了通过在羧基，胺或羟基中形成一个或两个末端官能团，生成一种或多种庚二酸，7-氨基庚酸，7-羟基庚酸，七亚甲基二胺和1,7-庚二醇的生化途径 由琥珀酸半醛或丙酮酸生成的C7脂肪族主链基质。 本文描述的这些途径，代谢工程和培养策略依赖于琥珀酸半醛和丙酮酸的醛醇缩合。
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14.发明申请METHODS OF PRODUCING 7-CARBON CHEMICALS VIA CoA-DEPENDENT CARBON CHAIN ELONGATION ASSOCIATED WITH CARBON STORAGE 审中-公开通过与碳存储相关的与CoA相关的碳链延长生产7-碳化合物的方法
公开(公告)号：WO2014093847A2
公开(公告)日：2014-06-19
申请号：PCT/US2013/075058
申请日：2013-12-13
Applicant: INVISTA NORTH AMERICA S.A.R.L.
Inventor： BOTES, Adriana Leonora , CONRADIE, Alex Van Eck
IPC: C12P7/18
CPC classification number: C12P13/005 , C12N9/1029 , C12N9/93 , C12P7/18 , C12P7/42 , C12P7/44 , C12P13/001 , C12P13/002
Abstract: This document describes biochemical pathways for producing pimelic acid, 7-hydroxyheptanoic acid, 7-aminoheptanoic acid, heptamethylenediamine or 1,7-heptanediol by forming two terminal functional groups, comprised of carboxyl, amine or hydroxyl group, in a C7 aliphatic backbone substrate. These pathways, metabolic engineering and cultivation strategies described herein rely on the CoA-dependent elongation enzymes or analog enzymes associated with the carbon storage pathways from polyhydroxyalkanoate accumulating bacteria.
Abstract translation: 该文献描述了通过形成由羧基，胺或羟基组成的两个末端官能团来生产庚二酸，7-羟基庚酸，7-氨基庚酸，七亚甲基二胺或1,7-庚二醇的生物化学途径 在C7脂肪族主链底物中。 本文描述的这些途径，代谢工程和培养策略依赖于与来自聚羟基链烷酸酯积累细菌的碳存储途径相关的CoA依赖性延伸酶或类似酶。
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15.发明公开METHODS OF PRODUCING 7-CARBON CHEMICALS VIA METHYL-ESTER SHIELDED CARBON CHAIN ELONGATION 审中-公开用于生产7-CARBON化学BY METHYLESTERABGESCHIRMTE碳链延长
公开(公告)号：EP2938733A2
公开(公告)日：2015-11-04
申请号：EP13824255.7
申请日：2013-12-23
Applicant: Invista North America S.a.r.l.
Inventor： BOTES, Adriana Leonora , CONRADIE, Alex Van Eck , CHEN, Changlin , PEARLMAN, Paul S.
CPC classification number: C12P13/001 , C12N15/52 , C12P7/18 , C12P7/42 , C12P7/44 , C12P13/005
Abstract: This document describes biochemical pathways for producing pimelic acid, 7-aminoheptanoic acid, 7-hydroxyheptanoic acid, heptamethylenediamine or 1,7-heptanediol by forming two terminal functional groups, comprised of carboxyl, amine or hydroxyl group, in a C7 aliphatic backbone substrate. These pathways, metabolic engineering and cultivation strategies described herein rely on enzymes or homologs accepting methyl ester shielded dicarboxylic acid substrates.
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